HBV基因型与HBeAg的表达关系及其临床意义

汪莉萍; 韩方正; 吴光辉

HBV基因型与HBeAg的表达关系及其临床意义

徐州医学院传染病学教研室

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中图分类号: R512.62
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出版历程
- 出版日期: 2011-05-20

Relationship between the genotypes of hepatitis B virus and the expression of HBeAg and its clinical significance

摘要

摘要: 目的观察慢性乙型肝炎病毒（HBV）感染者HBV基因型与HBeAg表达和病情轻重的关系。方法利用型特异性引物多重PCR方法检测HBV基因型,时间分辨荧光法检测HBV DNA。结果在120例慢性乙型肝炎病毒感染者中HBV基因型C型84例（70%）、B型31例（25.8%）,BC混合型5例（4.2%）,未发现A、D、E、F基因型;C型在慢性重型肝炎组最高（P<0.05）;在C基因型中HBeAg（+）患者较HBeAg（-）患者多见（P<0.05）,在B基因型中,HBeAg（+）和HBeAg（-）患者分布无明显差别。结论徐州地区HBV基因型以C型和B型多见,e抗原的表达率在C型中较高;基因型B型与C型相比,C型引起肝脏损伤重。
- 肝炎病毒,乙型 /
- 肝炎e抗原,乙型 /
- 基因型 /
- 基因表达
Abstract: Objective To investigate the relationship between different genotypes of hepatitis B virus (HBV) and the expression of HBeAg and the severity of liver diseases.Methods The HBV genotypes were determined by multiple-primer PCR amplification and the HBV DNA levels were detected by fluorescent quantitative PCR assay.Results In 120 HBV infected cases, 84 cases (70%) were genotype C, 31 cases (25.8%) were genotype B and 5 cases (4.2%) were mixed genotype BC;genotypes A, D, E, F were not detected.More patients were HBeAg-positive than were HBeAg-negative in Genotype C (P<0.05) .There was no significant difference between the HBeAg negative and HBeAg positive in genotyoe B.Conclusion This study suggests that genotype B and C are predominant genotype in Xuzhou area.The HBeAg positive expression is predominant in genotype C.Compare to the patients with genotype B, more severe inflammation was observed in patients with genotype C.
- hepatitis B virus /
- hepatitis B e antigens /
- genotype /
- gene expression

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参考文献(13)

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