丙型肝炎病毒所致胰岛素抵抗相关分子的研究进展

李静; 陈红; 张立婷; 刘鹏

丙型肝炎病毒所致胰岛素抵抗相关分子的研究进展

兰州大学第一医院感染科

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中图分类号: R512.63
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出版历程
- 出版日期: 2011-05-20

Progress in molecular research related to insulin resistance in chronic hepatitis C

摘要

摘要: 慢性丙型肝炎(CHC)患者易发生胰岛素抵抗(IR)。实验表明CHC相关IR不但与肝脂肪变性、肝纤维化、食管静脉曲张、肝细胞肝癌、肝癌扩散及一些肝外临床表现有关,还降低了以干扰素(IFN)联合利巴韦林为基础的抗病毒治疗早期及持续应答率。已有较多实验利用各种模型分析了丙型肝炎病毒(CHV)导致IR的发病机制,现对当前研究已知的几个分子及其机制做一综述。
- 胰岛素抗药性 /
- 肝炎,丙型,慢性 /
- 肝炎病毒属
Abstract: Patients with chronic hepatitis C are liable to insulin resistance.Evidence suggests that insulin resistance is not only related with steatosis, hepatic fibrosis, esophageal varices, hepatocarcinogenesis, proliferation of hepatocellular carcinoma and some extrahepatic manifestations but also related with the reduction of the early and sustained virological response to the interferon-alpha-based therapy.The effect of HCV on insulin signaling has been analyzed in some experiments using kinds of models.The authors review the current understanding of the Molecular mechanisms of insulin resistance in chronic hepatitis C.
- insulin resistance /
- hepatitis C /
- chronic

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参考文献(23)

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