小儿重型肝炎患者外周血T淋巴细胞亚群的变化与临床意义

丁巧云; 俞海英; 孙薇薇; 潘剑; 曹兴国; 王雷

小儿重型肝炎患者外周血T淋巴细胞亚群的变化与临床意义

东南大学附属第二医院

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中图分类号: R725.1
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出版历程
- 出版日期: 2011-07-20

The changes of peripheral blood T-lymphocyte subsets in pediatric severe hepatitis

摘要

摘要: 目的了解小儿与成人重型肝炎外周血CD3+、CD3+CD4+及CD3+CD8+T淋巴细胞数量变化的差别,探讨小儿重型肝炎患者外周血T淋巴细胞亚群数量变化与临床意义。方法对35例小儿及30例成人重型肝炎进行外周血CD3+、CD3+CD4+及CD3+CD8+T淋巴细胞数量检测。结果小儿重型肝炎成活的患儿外周血CD3+、CD3+CD4+及CD3+CD8+T淋巴细胞数量明显高于死亡组（P<0.01）;小儿重型肝炎中1岁以内患儿外周血CD3+、CD3+CD4+及CD3+CD8+T淋巴细胞数量明显高于2～6岁组（P<0.01）;小儿重型肝炎组CD3+、CD3+CD4+及CD3+CD8+T淋巴细胞数量明显高于成人重型肝炎组（P<0.01）;1岁以内的患儿病死率最高（P<0.05）。结论小儿与成人重型肝炎外周血CD3+、CD3+CD4+及CD3+CD8+T淋巴细胞数量有明显差异,年龄越小,CD3+、CD3+CD4+及CD3+CD8+T淋巴细胞数量越高;小儿细胞免疫与成人明显不同,年龄越小,病情越重;病死率越高。
- 肝炎 /
- T淋巴细胞亚群
Abstract: Objective To compare the levels of CD3+, CD3+ CD4+ and CD3+ CD8+ T-lymphocytes in peripheral blood between pediatric and adult patients with severe hepatitis.Methods Peripheral blood from 35 children and 30 adults with severe hepatitis was collected.The levels of peripheral blood CD3+, CD3+ CD4+ and CD3+CD8+ T-lymphocytes were detected by flow cytometry.Results Pediatric group, the first year of children with CD3+, CD3+ CD4+ and CD3+ CD8+ T-lymphocytes was significantly higher than the 2 to 6 years old group (P<0.01) ;pediatric group CD3+, CD3+ CD4+ and CD3+ CD8+ T-lymphocytes was significantly higher than the adult group (P<0.01) ;the first year of children with the highest mortality (P<0.05) .Conclusion Cellular immunity in children and adults is obviously different.the younger, the more severe disease, the higher mortality, the higher number of CD3+, CD3+ CD4+ and CD3+ CD8+ T-lymphocytes.Pediatric and adult hepatitis blood CD3+, CD3+CD4+ and CD3+ CD8+ T-lymphocytes were significantly different.
- hepatitis /
- T-lymphocytes subesets

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参考文献(5)

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