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兔VX2肝癌模型的建立及纳米微泡造影剂在模型早期检测中的应用

江翰 王雪峰 王子豪 徐斌 施伟斌

引用本文:
Citation:

兔VX2肝癌模型的建立及纳米微泡造影剂在模型早期检测中的应用

基金项目: 

上海市科委纳米专项项目(0952nm03800); 上海市教委科研与创新计划(09YZ103); 

详细信息
  • 中图分类号: R735.7

The establishment of rabbit VX2 hepatic tumor model and the application of nano-scale microbubble contrast agent in the diagnosis of this model

Research funding: 

 

  • 摘要: 目的通过建立一个原发性或转移性兔肝癌模型并应用纳米微泡造影剂对肿瘤进行早期检测,探讨纳米材料在肝癌超声诊断中的应用。方法通过肿瘤组织块接种法制备兔肝癌模型并利用门静脉插管注射微泡造影剂对比增强显影。结果模型建立后检测原位成瘤率为83.3%,采用5 MHz的发射频率,肝内主要血管及瘤块1 min内显影得到增强。结论靶向超声纳米对比剂具有特异性和敏感性,纳米级微泡造影剂用于超声造影增强是完全可行的。

     

  • [1]王宝恩, 张定凤.现代肝脏病学[M].北京:科学出版社, 2003, 8:851.
    [2]郭卫平, 刘燕, 王执民, 等.兔肝VX2移植癌改良模型的建立[J].中国医学影像技术, 2002, 18 (5) :397-399.
    [3]曹玮, 王执民, 张洪新, 等.兔VX2肝癌模型的移植方式及生长特性的研究[J].实用放射学杂志, 2003, 19 (2) :97-99.
    [4]Lin WY, Chen J, Lin Y, et al.Implantation of VX2 carcinoma into theliver of rabbits:a comparison of three direct-injection methods[J].JVet Med Sci, 2002, 64 (7) :649-652.
    [5]Izumi B, Tashiro S, Miyauchi Y, et al.Anticancer effects of localadministration of mitomycin C via the hepatic artery or portal veinon implantion and growth of VX2 cancer injected into rabbit liver[J].Cancer Res, 1986, 46 (8) :4167-4170.
    [6]Paeng JC, Jeong JM, Yoon CJ, et al.Lipiodol solution of 188ReHDDas a new therapeutic agent for transhepatic arterial embolizationin liver cancer:preclinical study in a rabbit liver cancer model[J].Nucl Med, 2003, 44 (12) :2033-2038.
    [7]Yoon CJ, Chung JW, Park JH, et al.Transcatheter arterialchemoembolization with paclitaxel-lipiodol solution in rabbit VX2liver tumour[J].Radiology, 2003, 229 (1) :126-131.
    [8]Hansler J, Neureiter D, Wasserburger M, et al.Percutaneous US-guided radiofrequency ablation with perfused needle applicators:improved survival with the VX2 tumor model in rabbits[J].Radiology, 2004, 230 (1) :169-174.
    [9]Lindell B, AronSen KF, Rothman U, et al.Repated arterialembolization of rat livers by de-grdable microspheres[J].Eur SurgRes, 1988, 9 (5) :347-35.
    [10]红雷, 张玉, 栗林.兔摄食行为的观察与分析[J].畜牧与饲料科学, 2005, 26 (6) :47-48.
    [11]Nagata Y, Fujiwara K, Okajima K, et al.Transcatheter arterialembolization for malignant osseous and soft tissue sarcomas.Ⅰ.Arabbit experimental model[J].Cardiovase Intervent Radiol, 1998, 21 (3) :205-207.
    [12]Ko YH, Pedersen PL, Geschwind JF.Glucose catabolism in therabbit VX2 tumor model for liver cancer:characterization andtargeting hexokinase[J].Cancer Lett, 2001, 173 (1) :83-91.
    [13]Moroz P, Jones SK, Winter J, et al.Targeting liver tumors withhyperthermia:ferromagnetic embolization in a rabbitliver tumormodel[J].J Surg Oncol, 2001, 78 (1) :22-29.
    [14]王学梅, 周旭.肝癌超声诊断与治疗现状综合论坛[J].超声医学论坛, 2002, 8 (1) :6466.
    [15]Ogata R, Majima Y, Tateishi Y, et al.Bright loop apperance;a characteristic ultrasonography sign of early hepatocellularcarcinoma[J].Oncol Rep, 2000, 7 (6) :1293-1298.
    [16]李杰, 梁萍.彩色多着超声和超声造影在肝脏占住性病变中的应用进展[J].消化外科, 2002, 1 (5) :377-380.
    [17]Deng CX, Lizzi FL.A review of physical phenomena associated withultrasonic contrast agents and illustrative clinical applications[J].Ultrasound Med Biol, 2002, 28 (3) :277-286.
    [18]Voigt JU.Ultrasound molecular imaging[J].Methods, 2009, 48:92-97.
    [19]Pike R, Sabatier P.Scattering:scattering and inverse scattering inpure and applied science[M].London:Academic Press, 2002:162-174.
    [20]Guan J, Matula TJ.Using light scattering to measure the responseof individual ultrasound contrast microbubbles subjected to pulsedultrasound in vitro[J].J Acoust Soc Am, 2004, 116 (5) :2832-2842.
    [21]Mattrey RF, Aguirre DA.Advances in contrast media research[J].Acdemic Radiology, 2003, 10 (12) :1450-1460.
    [22]Oeffinger BE, Wheatley MA.Development and characterization of anano-scale contrast agent[J].Ultrasonics, 2004, 42 (5) :343-347.
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  • 出版日期:  2011-07-20
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