肝脏自然杀伤细胞在慢性肝病中的作用

程琦; 施光峰

肝脏自然杀伤细胞在慢性肝病中的作用

程琦,
施光峰

复旦大学附属华山医院感染科

基金项目:

国家973课题资助项目(2007CB512904)；国家十一五重大科技专项资助项目(2008ZX1002-004)；

详细信息

中图分类号: R575
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出版历程
- 出版日期: 2011-07-20

Role of liver NK cells in chronic liver diseases

Research funding:

摘要

摘要: 肝脏自然杀伤细胞(NK)是一种与外周血NK细胞不同的肝脏免疫细胞。近年来研究表明肝脏NK细胞在各种慢性肝脏疾病中起重要作用。包括对抑制病毒感染和肿瘤细胞生长,对抗肝纤维化均有益处,但同时其又刺激肝损伤和抑制肝再生(肝细胞增殖)。本文就肝脏NK细胞的特征、功能以及在各种常见慢性肝病中作用进展作一综述。
- 杀伤细胞,天然 /
- 肝细胞 /
- 肝疾病
Abstract: Liver natural killer cells (NK) cells are one type of hepatic immune cells derived from peripheral blood NK cells.Recent studies show that liver NK cells play an important role in various chronic liver diseases, including inhibition of viral infection and tumor cell growth and anti fibrosis.On the other hand, they also cause liver injury and inhibit liver regeneration.In this paper, the features and functions of liver NK cells and the recent progress of the role of liver NK cells in chronic liver disease are reviewed.
- killer cells /
- natural /
- hepatocytes

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参考文献(25)

[1]Pillarisetty VG, Katz SC, Bleier JI, et al.Natural killer dendritic cellshave both antigen presenting and lytic function and in responseto CpG produce IFN-γvia autocrine IL-12[J].J Immunol, 2005, 174 (5) :2612-2618.

[2]Bordoni V, Alonzi T, Agrati C, et al.Murine hepatocyte cell linespromote expansion and differentiation of NK cells from stem cellprecursors[J].Hepatology, 2004, 39 (6) :1508-1516.

[3]Jeong WI, Park O, Radaeva S, et al.STAT1 inhibits liver fibrosis inmice by inhibiting stellate cell proliferation and stimulating NK cellcytotoxicity[J].Hepatology, 2006, 44 (6) :1441-1451.

[4]Radaeva S, Jaruga B, Hong F, et al.Interferon-γactivates multipleSTAT signals and down-regulates c-Met in primary humanhepatocytes[J].Gastroenterology, 2002, 122 (4) :1020-1034.

[5]Subleski JJ, Hall VL, Back TC, et al.Enhanced antitumor responseby divergent modulation of natural killer and natural killer T cells inthe liver[J].Cancer Res, 2006, 66 (22) :11005-11012.

[6]Vanderkerken K, Bouwens L, Van Rooijen N, et al.The role ofKupffer cells in the differentiation process of hepatic natural killercells[J].Hepatology, 1995, 22 (1) :283-290.

[7]Gao B, Radaeva S, Park O.Liver natural killer and natural killer Tcells:immunobiology and emerging roles in liver diseases[J].JLeuko Biol, 2009, 86 (3) :513-528.

[8]邹勇, 陈韬, 王洪武, 等.肝脏自然杀伤细胞在小鼠急性肝衰竭中的作用[J].中华肝脏病杂志, 2008, 16 (9) :660-664.

[9]Sun R, Park O, Horiguchi N, et al.STAT1 contributes to dsRNAinhibition of liver regeneration after partial hepatectomy in mice[J].Hepatology, 2006, 44 (4) :955-966.

[10]Melhem A, Muhanna N, Bishara A, et al.Anti-fibrotic activity of NKcells in experimental liver injury through killing of activated HSC[J].J Hepatol, 2006, 45 (1) :60-71.

[11]Jeong WI, Park O, Gao B.Abrogation of the antifibrotic effects ofnatural killer cells/interferon-γcontributes to alcohol accelerationof liver fibrosis[J].Gastroenterology, 2008, 134 (1) :248-258.

[12]Morishima C, Paschal DM, Wang CC, et al.Decreased NK cellfrequency in chronic hepatitis C does not affect exvivo cytolytickilling[J].Hepatology, 2006, 43 (3) :573-580.

[13]Muhanna N, Tair LA, Doron S, et al.Amelioration of hepatic fibrosisby NK cell activation[J].Gut, 2011, 60 (1) :90-98.

[14]Sun R, Gao B.Negative regulation of liver regeneration by innateimmunity (natural killer cells/interferon-γ) [J].Gastroenterology, 2004, 127 (5) :1525-1539.

[15]范荣山, 石理兰, 冯国和, 等.实验性暴发性肝衰竭大鼠肝脏NK细胞与肝再生的关系[J].中国医科大学学报, 2003, 32 (4) :321-323.

[16]Hines IN, Kremer M, Isayama F, et al.Impaired liver regenerationand increased oval cell numbers following T cell-mediatedhepatitis[J].Hepatology, 2007, 46 (1) :229-241.

[17]Strick-Marchand H, Masse GX, Weiss MC, et al.Lymphocytessupport oval cell-dependent liver regeneration[J].J Immunol, 2008, 181 (4) :2764-2771.

[18]Larkin J, Bost A, Glass JI, et al.Cytokine-activated natural killer cellsexert direct killing of hepatoma cells harboring hepatitis C virusreplicons[J].J Interferon Cytokine Res, 2006, 26 (12) :854-865.

[19]Ahlenstiel G, Titerence RH, Koh C, et al.Natural killer cells arepolarized toward cytotoxicity in chronic hepatitis C in an interferon-α-dependent manner[J].Gastroenterology, 2010, 138 (1) :325-335.

[20]Pelletier S, Drouin C, Bedard N, et al.Increased degranulation ofnatural killer cells during acute HCV correlates with the magnitude ofvirus-specific T cell responses[J].J Hepatol, 2010, 53 (5) :805-816.

[21]Nattermann J, Feldmann G, Ahlenstiel G, et al.Surface expressionand cytolytic function of natural killer cell receptors is altered inchronic hepatitis C[J].Gut, 2006, 55 (6) :869-877.

[22]Jeong WI, Park O, Gao B.Abrogation of the antifibrotic effects ofnatural killer cells/interferon-γcontributes to alcohol accelerationof liver fibrosis[J].Gastroenterology, 2008, 134 (1) :248-258.

[23]Tian Z, Sun R, Wei H, et al.Impaired natural killer (NK) cell activityin leptin receptor deficient mice:leptin as a critical regulator inNK cell development and activation[J].Biochem Biophys ResCommun, 2002, 298 (3) :297-302.

[24]Chuang YH, Lian ZX, Tsuneyama K, et al.Increased killing activityand decreased cytokine production in NK cells in patients withprimary biliary cirrhosis[J].J Autoimmun, 2006, 26 (4) :232-240.

[25]周霖, 蔡伦, 张政, 等.肝癌患者外周血自然杀伤细胞的功能分析[J].中华肝脏病杂志[J].2010, 18 (2) :136-139.

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