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微生态调节剂治疗重型肝炎内毒素血症的研究进展

罗明 曹武奎

引用本文:
Citation:

微生态调节剂治疗重型肝炎内毒素血症的研究进展

基金项目: 

国家“十一五”科技重大专项(2008ZX10005-007); 天津市卫生局科技基金(09KY03); 

详细信息
  • 中图分类号: R575.1

Research progress on microbial modulators in treatment of severe hepatitis with endotoxemia

Research funding: 

 

  • 摘要: 肠源性内毒素血症是慢性重型肝炎发生和发展的重要机制之一。各种微生态制剂可调整肠道失调菌群,从而降低血清内毒素水平,减少并发症和降低病死率,对慢性重型肝炎有明显的治疗作用。

     

  • [1]Nolan JP.The role of intestinal endotoxin in liver injury:a long andevolving history[J].Hepatology, 2010, 52 (5) :1829-1835.
    [2]Balzan S, de Almeida Quadms C, de Cleva R, et al.Bacterialtranslocation:overview of mechanisms and clinical impact[J].Gastroenterol Hepatol, 2007, 22 (4) :464-471.
    [3] 叶一农, 高志良.乙型肝炎肝衰竭发生机制中的三重打击[J].中华肝脏病杂志, 2009, 8 (17) :638-639.
    [4]Bernardi M.Spontaneous bacterial peritonitis:frompathophysiology to prevention[J].Intern Emerg Med, 2010, 5 (1) :37-44.
    [5]Zhang HY, Han de W, Su AR, et al.Intestinal endotoxemia playsa central role in development of hepatopulmonary syndrome ina cirrhotic rat model induced by multiple pathogenic factors[J].World J Gastroenterol, 2007, 13 (47) :6385-6395.
    [6]Yu LX, Yan HX, Liu Q, et al.Endotoxin accumulation preventscarcinogen-induced apoptosis and promotes liver tumorigenesisin rodents[J].Hepatology, 2010, 52 (4) :1322-1333.
    [7]卢明芹, 郑宇, 陈永平, 等.微生态制剂对重型肝炎患者血清细胞因子的影响[J].中华肝脏病杂志, 2008, 16 (4) :632-634.
    [8]Scarpellini E, Cazzato A, Lauritano C, et al.Probiotics:whichand when?[J].Dig Dis, 2008, 26 (2) :175-182.
    [9]Oasman N, Adawi D, Ahrne S, et al.Endotoxin-andD-galactosamine induced liver injury improved by theadministration of lactobacillus, bifidobacterium and blueberry[J].Digestive and liver disease, 2007, 39 (9) :849-856.
    [10]van Erpecum KJ.Ascites and spontaneous bacterial peritonitisin patients with liver cirrhosis[J].Scand J Gastroenterol Suppl, 2006, 2 (43) :79-84.
    [11]Zhang W, Gu Y, Chen Y, et al.Intestinal flora imbalance resultsin altered bacterial translocation and liver function in rats withexperimental cirrhosis[J].Eur J Gastroenterol Hepatol, 2010, 22 (12) :1481-1486.
    [12]Gurusamy KS, Kumar Y, Davidson BR.Methods of preventingbacterial sepsis and wound complications for livertransplantation[J].Cochrane Database Syst Rev, 2008, 8 (4) :666-670.
    [13]Ko JS, Yang HR, Chang JY, et al.Lactobacillus plantaruminhibits epithelial barrier dysfunction and interleukin-8 secretioninduced by tumor necrosis factor-α[J].World J Gastroenterol, 2007, 13 (13) :1962-1965.
    [14]Sorokulova IB, Pinchuk IV, Denayrolles M, et al.The safety oftwo Bacillus probiotic strains for human use[J].Dig Dis Sci, 2008, 53 (4) :954-963.
    [15]Roberfroid M.Prebiotics:the concept revisited[J].J Nutr, 2007, 137 (3) :830-837.
    [16]Phongsamran PV, Kim JW, Cupo Abbott J, et al.Pharmacotherapy for hepatic encephalopathy[J].Drugs, 2010, 70 (9) :1131-1148.
    [17]Malaguarnera M, Gargante MP, Malaguarnera G, et al.Bifidobacterium combined with fructo-oligosaccharideversus lactulose in the treatment of patients with hepaticencephalopathy[J].Eur J Gastroenterol Hepatol, 2010, 22 (2) :199-206.
    [18]于建武, 高杰, 赵勇华, 等.乳果糖联合血浆置换治疗对慢性重型肝炎患者内毒素血症的影响[J].肝脏, 2006, 11 (1) :28-29.
    [19]Prasad S, Dhiman RK, Duseja A, et al.Lactulose improvescognitive functions and health-related quality of life in patientswith cirrhosis who have minimal hepatic encephalopathy[J].Hepatology, 2007, 45 (3) :549-559.
    [20]Chen C, Li L, Wu Z, et al.Effects of lactitol on intestinal microflora and plasma endotoxin in patients with chronic viralhepatitis[J].J Infect, 2007, 54 (1) :98-102.
    [21]Plauth M, CabréE, Campillo B, et al.ESPEN Guidelines onParenteral Nutrition:hepatology[J].Clin Nutr, 2009, 28 (4) :436-444.
    [22]Eguchi S, Takatsuki M, Hidaka M, et al.Perioperative synbiotictreatment to prevent infectious complications in patientsafter elective living donor liver transplantation:a prospectiverandomized study[J].Am J Surg, 2011, 201 (4) :498-502.
    [23]Liu Q, Duan ZP, Ha DK, et al.Synbiotic modulation of gut flora:effect on minimal hepatic encephalopathy in patients with livercirrhosis[J].Hepatology, 2004, 39 (5) :1441-1449.
    [24]Rayes N, Seehofer D, Neuhaus P.Prebiotics, probiotics, synbiotics in surgery--are they only trendy, truly effective or evendangerous?[J].Langenbecks Arch Surg, 2009, 394 (3) :547-555.
    [25]Rishi P, Mavi SK, Bharrhan S, et al.Protective efficacy ofprobiotic alone or in conjunction with a prebiotic in Salmonella-induced liver damage[J].FEMS Microbiol Ecol, 2009, 69 (2) :222-230.
    [26]占国清, 谭华炳, 李儒贵, 等.微生态调节剂在慢性重型肝炎患者的治疗作用[J].中国微生态学杂志, 2010, 22 (10) :935-937.
    [27]袁玉成, 曹胡林, 刘正广, 等.思连康与杜秘克联用对肝硬化并发重度腹水患者血清内毒素水平的影响[J].临床合理用药, 2009, 2 (6) :38-39.
    [28]Robinson CJ, Young VB.Antibiotic administration alters thecommunity structure of the gastrointestinal micobiota[J].GutMicrobes, 2010, 1 (4) :279-284.
    [29]Gratz SW, Mykkanen H, El-Nezami HS.Probiotics and gut health:a special focus on liver diseases[J].World J Gastroenterol, 2010, 16 (4) :403-410.
    [30]吴晓雷.抗生素联合整肠生对慢性重型肝炎自发性细菌性腹膜炎的研究[J].实用医技杂志, 2008, 15 (7) :873-874.
    [31]Mas A, Rodes J, Sunyer L, et al.Comparison of rifaximin andlactitol in the treatment of acute hepatic encephalopathy:resultsof a randomized, double-blind, double-dummy, controlledclinical trial[J].J Hepatol, 2003, 38 (1) :51-58.
    [32]Liong MT.Safety of probiotics:translocation and infection[J].Nutr Rev, 2008, 66 (4) :192-202.
    [33]Madsen K.Probiotics in critically ill patients[J].J Clin Gastr-oenterol, 2008, 42 (8) :116-118.
    [34]Shi SH, Kong HS, Jia CK, et al.Coagulase.negativestaphylococcus and enterococcus as predominant pathogens inliver transplant recipients with Gram-positive coccal bacteremia[J].Chinese Medical Journal, 2010, 123 (15) :1983-1988.
    [35]Jonkers D, Stockbrugger R.Review article:Probiotics ingastrointestinal and liver diseases[J].Aliment Pharmacol Ther, 2007, 26 (2) :133-148.
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  • 出版日期:  2011-07-20
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