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2010版《慢性乙型肝炎防治指南》解读——慢性乙型肝炎治疗目标和适应证

李海 贾继东

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2010版《慢性乙型肝炎防治指南》解读——慢性乙型肝炎治疗目标和适应证

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  • 中图分类号: R512.62

Interpretation of the guideline on prevention and treatment for chronic hepatitis B (2010 version) -the goals and indications for chronic hepatitis B treatment

  • 摘要: <正>中华医学会肝病学分会和感染病分会于2010年12月10日发布了2010年版《慢性乙型肝炎防治指南》(以下简称本指南)[1]。在2005年版指南的基础上[2],本指南吸收了近年国内外有关乙型肝炎预防、诊断及治疗的最新研究成果,按照循证医学原则,全

     

  • [1]贾继东, 李兰娟.慢性乙型肝炎防治指南 (2010年版) [J].临床肝胆病杂志, 2011, (1) :113-128.
    [2]中华医学会肝病学会.慢性乙型肝炎防治指南[J].临床肝胆病杂志, 2006, (1) :3-15.
    [3]Chen YC, Chu CM, Yeh CT, et al.Natural course following theonset of cirrhosis in patients with chronic hepatitis B:a long-termfollow-up study[J].Hepatol Int, 2007, 1 (1) :267-273.
    [4]Liaw YF.Natural history of chronic hepatitis B virus infection andlong-term outcome under treatment[J].Liver Int, 2009, 29 (Sup-pl 1) :100-107.
    [5]Yuen MF, Wong DK, Fung J, et al.HBsAg Seroclearance inchronic hepatitis B in Asian patients:replicative level and risk ofhepatocellular carcinoma[J].Gastroenterology, 2008, 135 (4) :1192-1199.
    [6]Lok AS, McMahon BJ.Chronic hepatitis B:update 2009[J].Hepatol-ogy, 2009, 50 (3) :661-697.
    [7]European Association For The Study Of The Liver.EASL Clinical Prac-tice Guidelines:management of chronic hepatitis B[J].J Hepatol, 2009, 50 (2) :227-242.
    [8]Hui CK, Leung N, Yuen ST, et al.Natural history and diseaseprogression in Chinese chronic hepatitis B patients in immune-tol-erant phase[J].Hepatology, 2007, 46 (2) :395-401.
    [9]Chu CM, Liaw YF.HBsAg seroclearance in asymptomatic carriers ofhigh endemic areas:appreciably high rates during a long-term follow-up[J].Hepatology, 2007, 45 (5) :1187-1192.
    [10]Chen CJ, Yang HI, Iloeje UH.Hepatitis B virus DNA levels andoutcomes in chronic hepatitis B[J].Hepatology, 2009, 49 (5 Sup-pl) :S72-84.
    [11]Villeneuve JP, Condreay LD, Willems B, et al.Lamivudine treat-ment for decompensated cirrhosis resulting from chronic hepatitis B[J].Hepatology, 2000, 31 (1) :207-210.
    [12]Perrillo RP, Wright T, Rakela J, et al.A multicenter United States-Canadian trial to assess lamivudine monotherapy be-fore and after liver transplantation for chronic hepatitis B[J].Hepa-tology, 2001, 33 (2) :424-432.
    [13]Hann HW, Fontana RJ, Wright T, et al.A United States compas-sionate use study of lamivudine treatment in nontransplantation can-didates with decompensated hepatitis B virus-related cirrhosis[J].Liver Transpl, 2003, 9 (1) :49-56.
    [14]Lo CM, Liu CL, Lau GK, et al.Liver transplantation for chronichepatitis B with lamivudine-resistant YMDD mutant using add-onadefovir dipivoxil plus lamivudine[J].Liver Transpl, 2005, 11 (7) :807-813.
    [15]Koda M, Nagahara T, Matono T, et al.Nucleotide analogs for pa-tients with HBV-related hepatocellular carcinoma increase the sur-vival rate through improved liver function[J].Intern Med, 2009, 48 (1) :11-17.
    [16]Keeffe EB, Dieterich DT, Han SH, et al.A treatment algorithm forthe management of chronic hepatitis B virus infection in the UnitedStates:an update[J].Clin Gastroenterol Hepatol, 2006, 4 (8) :936-962.
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    [18]Tai DI, Chen CH, Chang TT, et al.Eight-year nationwide surviv-al analysis in relatives of patients with hepatocellular carcinoma:role of viral infection[J].J Gastroenterol Hepatol, 2002, 17 (6) :682-689.
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