FibroScan在乙型肝炎诊断中的应用价值

苟艳子; 杨苏亚; 张方信; 康生朝; 梁振斌; 陈嘉屿; 汪咏; 王维; 潘蕾; 刘博; 白雪帆

FibroScan在乙型肝炎诊断中的应用价值

1. 兰州军区总医院消化科
2. 解放军第451医院药剂科
3. 解放军68302部队医院疼痛科
4. 第四军医大学唐都医院传染科

基金项目:

国家十一五课题基金(2008zx10002-004)；

详细信息

中图分类号: R512.62
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出版历程
- 出版日期: 2011-08-20

The application of FibroScan in the diagnosis of patients with hepatitis B virus infection

Research funding:

摘要

摘要: 目的研究Fibroscan在乙型肝炎病毒感染患者中的应用价值;评估肝纤维化测量值的变化及临床意义。方法本研究是一个随机、开放的临床研究。2009年7月至2010年2月的74例乙型肝炎感染患者均接受至少两次Fibroscan检查,血清中ALT、AST及TBil的检查采用自动分析仪检查,所有74例患者(22例慢性乙型肝炎,32例代偿性肝硬化,20例失代偿性肝硬化)接受替比夫定治疗。结果 22例慢性乙型肝炎患者FibroScan值治疗6个月后降低,在治疗前后两组FibroScan值差异有统计学意义;74例乙型肝炎病毒感染患者肝功能治疗6个月后降低,差异具有统计学意义。74例乙型肝炎病毒感染患者中,HA与LSM呈显著正相关性(r=0.517,P=0.048)。结论慢性乙型肝炎患者肝硬度经过治疗可以降低。在替比夫定治疗的慢性乙型肝炎患者中肝硬度值的变化是敏感的。FibroScan将是一个在临床新药实验中评价治疗效果的有用工具。
- 肝炎,乙型,慢性 /
- 肝硬化
Abstract: Objective The aim of this study was to evaluate the application of FibroScan in HBV patients and to evaluate the changes of liver stiffness measurement (LSM) in hepatitis B patients.Methods This study was a randomized, open-label clinical study.All 74 HBV patients who underwent at least two FibroScan measurements from July 2009 to February 2010 were included.The levels of ALT, AST and TBil in serum were examined by Automatic Analyzer.All the 74 patients (chronic hepatitis B n=22, compensated cirrhosis n=32, decompensated cirrhosis n=20) were treated with telbivudine.Results FibroScan values in hepatitis B patients decreased 6 months after treatment.There were significant differences in the patients pre-and post-therapy.The liver function of all the patients decreased significantly after 6 months.There was a significant relationship between the fibrosis index (HA) and LSM (r=0.517, P=0.048) in all patients.Conclusion Our findings suggest that liver stiffness can be improved by treatment in chronic hepatitis B patients.LSM changes were sensitive in the hepatitis B patients treated with Telbivudine.FibroScan can be a useful tool for assessing treatment efficacy in clinical trials of new drugs.
- hepatitis B /
- chronic

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参考文献(24)

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