中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

人子宫颈癌基因生物学功能研究进展及其在肝癌早期诊断中的潜在价值

郑俊福 闾军

引用本文:
Citation:

人子宫颈癌基因生物学功能研究进展及其在肝癌早期诊断中的潜在价值

基金项目: 

北京市自然科学基金(7092044); 

详细信息
  • 中图分类号: R735.7

The biological function of human cervical cancer oncogene and its potential value in the early diagnosis of hepatocellular carcinoma

Research funding: 

 

  • 摘要: 人子宫颈癌基因是一新发现的"干系(stem-line)"癌基因,具有多种生物学功能,在肿瘤组织中特异性高表达,正逐渐引起人们较大的兴趣并显示出其在肝癌早期诊断中的优势。本文从人子宫颈癌基因的结构、功能、致肿瘤的机制以及其在肝癌早期诊断中的潜在价值进行综述。

     

  • [1]Ko J, Lee YH, Hwang SY, et al.Identification and differential ex-pression of novel human cervical cancer oncogene HCCR-2 in hu-man cancers and its involvement in p53 stabilization[J].Onco-gene, 2003, 22 (30) :4679-4689.
    [2] Cho GW, Shin SM, Kim HK, et al. HCCR-1, a novel oncogene, encodes a mitochondrial outer membrane protein and suppresses the UVC-induced apoptosis[J]. BMC Cell Biol, 2007, 8: 50.
    [3] Ha SA, Shin SM, Lee YJ, et al. HCCRBP-1 directly interacting with HCCR-1 induces tumorigenesis through p53 stabilization[J]. Int J Cancer, 2008, 122 (3) : 501-508.
    [4]Shin SM, Chung YJ, Oh ST, et al.HCCR-1-interacting mole-cule“deleted in polyposis 1”plays a tumor-suppressor role in co-lon carcinogenesis[J].Gastroenterology, 2006, 130 (7) :2074-2086.
    [5] Hurlstone A, Clevers H. T-cell factors: turn-ons and turn-offs[J]. EMBO J, 2002, 21 (10) : 2303-2311.
    [6]Jia Y, Yang Y, Liu S, et al.SOX17 antagonizes WNT/beta-cate-nin signaling pathway in hepatocellular carcinoma[J].Epigenetics, 2010, 5 (8) :743-749.
    [7] ShulewitzM, Soloviev I, Wu T, et al. Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer[J]. Oncogene, 2006, 25 (31) : 4361-4369.
    [8]Cho GW, Kim MH, Kim SH, et al.TCF/beta-catenin plays animportant role in HCCR-1 oncogene expression[J].BMC Mol Bi-ol, 2009, 10:42.
    [9] Goswami A, Ranganathan P, Rangnekar VM. The phosphoinositide 3-kinase/Akt1 /Par-4 axis: a cancer-selective therapeutic target[J]. Cancer Res, 2006, 66 (6) : 2889-2892.
    [10] Cho GW, Shin SM, Namkoong H, et al. The phosphatidylinositol 3-kinase/Akt pathway regulates the HCCR-1 oncogene expression[J]. Gene, 2006, 384: 18-26.
    [11]Li CM, Narayanan R, Lu Y, et al.2-Arylthiazolidine-4-car-boxylic acid amides (ATCAA) target dual pathways in cancer cells:5'-AMP-activated protein kinase (AMPK) /mTOR and PI3K/Akt/mTOR pathways[J].Int J Oncol, 2010, 37 (4) :1023-1030.
    [12] Chen J, Gomes AR, Monteiro LJ, et al. Constitutively Nuclear FOXO3a Localization Predicts Poor Survival and Promotes Akt Phosphorylation in Breast Cancer[J]. PLoS One, 2010, 5 (8) : e12293.
    [13]Xu Z, Zhang Y, Jiang JK, et al.Epidermal growth factor inducesHCCR expression via PI3K/Akt/mTOR signaling in PANC-1 pan-creatic cancer cells[J].BMC Cancer, 2010, 10:161.
    [14] Nagata Y, Takahashi A, Ohnishi K, et al. Effect of rapamycin, an mTOR inhibitor, on radiation sensitivity of lung cancer cells having different p53 gene status[J]. Int J Oncol, 2010, 37 (4) : 1001-1010.
    [15]Le Mellay V, Troppmair J, Benz R, et al.Negative regulation ofmitochondrial VDAC channels by C-Raf kinase[J].BM Cell Bi-ol, 2002, 3 (1) :14.
    [16] Lee HC, Li SH, Lin JC, et al. Somatic mutations in the D-loop and decrease in the copy number of mitochondrial DNA in human hepatocellular carcinoma[J]. Mutat Res, 2004, 547 (1-2) : 71-78.
    [17] Zotova L, Aleschko M, Sponder G, et al. Novel components of an active mitochondrial K (+) /H (+) exchange[J]. J Biol Chem, 2010, 285 (19) : 14399-14414.
    [18] Beppu T, Gil-Bernabe P, Boveda-Ruiz D, et al. High incidence of tumors in diabetic thrombin activatable fibrinolysis inhibitor and apolipoprotein E double deficient mice J[J]. Thromb Haemost, 2010, 8 (11) : 2514-2522.
    [19] Porrata-Doria T, Matta JL, Acevedo SF. Apolipoprotein E Allelic Frequency Altered in Women with Early-onset Breast Cancer[J]. Breast Cancer (Auckl) , 2010, 4: 43-48.
    [20] Su WP, Chen YT, Lai WW, et al. Apolipoprotein E expression promotes lung adenocarcinoma proliferation and migration and as a potential survival marker in lung cancer[J]. Lung Cancer, 2011, 71 (1) : 28-33.
    [21] Ha SA, Shin SM, Kim HK, et al. Dual action of apolipoprotein E-interacting HCCR-1 oncoprotein and its implication for breast cancer and obesity[J]. J Cell Mol Med, 2009, 13 (9B) : 3868-3875.
    [22]van der Pluijm G.Epithelial plasticity, cancer stem cells and bone me-tastasis formation[J].Bone, 2010, 48 (1) :37-43.
    [23] Ha SA, Kim HK, Yoo J, et al. Transdifferentiation-inducing HCCR-1 oncogene[J]. BMC Cell Biol, 2010, 11: 49.
    [24] Talos F, Moll UM. Role of the p53 family in stabilizing the genome and preventing polyploidization[J]. Adv Exp Med Biol, 2010, 676: 73-91.
    [25] Bourdon JC. p53 and its isoforms in cancer[J]. Br J Cancer, 2007, 97 (3) : 277-282.
    [26]Oh YT, Chun KH, Park BD, et al.Regulation of cyclin-depend-ent kinase inhibitorp21WAF1/CIP1 by protein kinase Cdelta-me-diated phosphorylation[J].Apoptosis, 2007, 12 (7) :1339-1347.
    [27] Ko J, Shin SM, Oh YM, et al. Transgenicmousemodel for breast cancer: induction of breast cancer in novel oncogene HCCR-2 transgenic mice[J]. Oncogene, 2004, 23 (10) : 1950-1953.
    [28]Ha SA, Lee YS, Shin SM, et al.Oncoprotein HCCR-1 expressionin breast cancer is well correlated with known breast cancer prognos-tic factors including the HER2 overexpression, p53 mutation, andER/PR status[J].BMC Cancer, 2009, 9:51.
    [29]Yang Y, Zhou XF, Liu AD.The inhibition effect and its molecularmechanism of human cervical cancer oncogene siRNA on hepatocar-cinoma cells[J].Zhonghua Gan Zang Bing Za Zhi, 2008, 16 (8) :612-615.
    [30]Yang Y, Zhang GX, Shi RH, et al.Overexpression of HCCR in hepa-tocellular carcinoma cells and its clinical significance[J].ZhonghuaGan Zang Bing Za Zhi, 2007, 15 (3) :223-224.
    [31]Yoon SK, Lim NK, Ha SA, et al.The human cervical cancer onco-gene protein is a biomarker for human hepatocellular carcinoma[J].Cancer Res, 2004, 64 (15) :5434-5441.
  • 加载中
计量
  • 文章访问数:  3667
  • HTML全文浏览量:  8
  • PDF下载量:  799
  • 被引次数: 0
出版历程
  • 出版日期:  2011-08-20
  • 分享
  • 用微信扫码二维码

    分享至好友和朋友圈

目录

    /

    返回文章
    返回