烟台地区慢性乙型肝炎患者病毒基因型分布与临床特征分析

刘锦屏; 刘友德; 郭砚梅; 杨绍萍; 林青; 林玲

烟台地区慢性乙型肝炎患者病毒基因型分布与临床特征分析

烟台市传染病医院

基金项目:

烟台市科学技术发展计划(2008603)；

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中图分类号: R512.62
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出版历程
- 出版日期: 2011-12-20

Clinical characteristics and distribution of hepatitis B virus genotypes in CHB patients in Yantai area

Research funding:

摘要

摘要: 目的了解烟台地区慢性乙型肝炎患者HBV基因型的分布及其与临床的关系。方法采用实时荧光定量PCR法,检测362例慢性乙型肝炎患者HBV基因型,并分析不同基因型之间性别、年龄及ALT、HBV DNA定量、HBeAg状态的差异。结果 362例标本中,B基因型7例(1.9%),C基因型344例(95.0%),非B非C型11例(3.0%)。B基因型患者年龄(36.29±17.54)岁,C基因型患者年龄(37±10.64)岁,非B非C型患者年龄(45.09±10.67)岁,P=0.050;两两比较提示C基因型患者年龄较非B非C型患者年龄低,P=0.015,余差异无统计学意义。不同基因型之间性别及ALT、HBV DNA定量、HBeAg状态的差异均无统计学意义。结论烟台地区慢性乙型肝炎患者HBV以基因C型为主,存在少量基因B型及非B非C型。不同基因型患者年龄可能存在差异。
- 肝炎,乙型,慢性 /
- 基因型 /
- 肝炎病毒,乙型
Abstract: Objective To investigate the clinical characteristics and distribution of hepatitis B virus (HBV) genotypes in Yantai city.Methods HBV genotypes were detected in 362 patients with chronic HBV infection using Real-time PCR.Results HBV genotype B, C and non-B or non-C were identified in 7 (1.9%) , 344 (95.0%) and 11 (3.0%) patients respectively.The age of patients infected with HBV genotype B, C and non-B or non-C is 36.29±17.54, 37±10.64 and 45.09±10.67 respectively (P=0.050) .No significant difference was found in the positive rate of HBeAg or the serum level of ALT, HBV DNA among the patients with genotype B, C and non-B or non-C (P>0.005) .Conclusion Genotype B, C and non-B or non-C have been found in the CHB patients of Yantai city and genotype C is the predominant genotype found.There maybe significant difference among the ages of patients infected with different HBV genotypes.
- hepatitis B /
- chronic /
- genotypes

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