烟台地区慢性乙型肝炎患者病毒基因型分布与临床特征分析

刘锦屏; 刘友德; 郭砚梅; 杨绍萍; 林青; 林玲

烟台地区慢性乙型肝炎患者病毒基因型分布与临床特征分析

烟台市传染病医院

基金项目:

烟台市科学技术发展计划(2008603)；

详细信息

中图分类号: R512.62
计量
- 文章访问数: 3468
- HTML全文浏览量: 9
- PDF下载量: 636
- 被引次数: 0
出版历程
- 出版日期: 2011-12-20

Clinical characteristics and distribution of hepatitis B virus genotypes in CHB patients in Yantai area

Research funding:

摘要

摘要: 目的了解烟台地区慢性乙型肝炎患者HBV基因型的分布及其与临床的关系。方法采用实时荧光定量PCR法,检测362例慢性乙型肝炎患者HBV基因型,并分析不同基因型之间性别、年龄及ALT、HBV DNA定量、HBeAg状态的差异。结果 362例标本中,B基因型7例(1.9%),C基因型344例(95.0%),非B非C型11例(3.0%)。B基因型患者年龄(36.29±17.54)岁,C基因型患者年龄(37±10.64)岁,非B非C型患者年龄(45.09±10.67)岁,P=0.050;两两比较提示C基因型患者年龄较非B非C型患者年龄低,P=0.015,余差异无统计学意义。不同基因型之间性别及ALT、HBV DNA定量、HBeAg状态的差异均无统计学意义。结论烟台地区慢性乙型肝炎患者HBV以基因C型为主,存在少量基因B型及非B非C型。不同基因型患者年龄可能存在差异。
- 肝炎,乙型,慢性 /
- 基因型 /
- 肝炎病毒,乙型
Abstract: Objective To investigate the clinical characteristics and distribution of hepatitis B virus (HBV) genotypes in Yantai city.Methods HBV genotypes were detected in 362 patients with chronic HBV infection using Real-time PCR.Results HBV genotype B, C and non-B or non-C were identified in 7 (1.9%) , 344 (95.0%) and 11 (3.0%) patients respectively.The age of patients infected with HBV genotype B, C and non-B or non-C is 36.29±17.54, 37±10.64 and 45.09±10.67 respectively (P=0.050) .No significant difference was found in the positive rate of HBeAg or the serum level of ALT, HBV DNA among the patients with genotype B, C and non-B or non-C (P>0.005) .Conclusion Genotype B, C and non-B or non-C have been found in the CHB patients of Yantai city and genotype C is the predominant genotype found.There maybe significant difference among the ages of patients infected with different HBV genotypes.
- hepatitis B /
- chronic /
- genotypes

HTML全文

参考文献(13)

[1]Norder H, Courouce AM, Coursaget P, et al.Genetic diver-sity of hepatitis B virus strains derived worldwide:geno-types, subgenotypes, and HbsAg subtypes[J].Intervirolo-gy, 2004, 47 (2) :289-309.

[2]陈林, 盛吉芳.乙型肝炎病毒基因型与临床病情进展的关系[J].国外医学.流行病学传染病学分册, 2005, 32 (6) :359-363.

[3]李雅娟, 庄辉, 李杰, 等.乙型肝炎病毒基因型和亚型的分布及其与临床的相关性[J].中华肝脏病杂志, 2005, 13 (3) :724-729.

[4]宋淑静, 何忠平, 庄辉, 等.中国北方5城市慢性乙型肝炎患者的基因分型[J].中国公共卫生, 2004, 20 (1) :166-167.

[5]Zeng G, Wang Z, Wen S, et al.Geographic distribution, vir-ologic and clinical characteristics of hepatitis B virus geno-types in china[J].J Viral Hepat, 2005, 12 (3) :609-617.

[6]刘爱平, 徐洪涛, 邢同京, 等.乙肝病毒基因分型与慢性乙型肝炎患者临床和病理的相关性研究[J].中西医结合肝病杂志, 2010, 20 (3) :175-177.

[7]谭文婷, 邓国宏, 王宇明, 等.重庆地区乙肝病毒基因型分布及其临床意义[J].第三军医大学学报, 2008, 30 (24) :2321-2323.

[8]陈公英, 邵俊斌, 徐岱, 等.浙江省乙型肝炎病毒B、C基因型感染者临床和肝组织病理的比较[J].中华传染病杂志, 2006, 24 (2) :113-115.

[9]王磊, 周培静, 耿大影, 等.山东地区HBeAg阳性慢性乙型肝炎患者病毒基因型和亚型分布与临床[J].中华肝脏病杂志, 2007, 15 (1) :149-150.

[10]Chu CJ, Keeffe EB, Han RP, et al.Hepatitis B virus geno-types in the United States:results of a nation wide study[J].Gastroenterology, 2003, 125 (3) :444-451.

[11]Kao JH, Chen PJ, Lai MY, et al.Genotypes and clinical phe-notypes of hepatitis B virus in patients with chronic hepatitisB virus infection[J].J Clinical Mirobiol, 2002, 40 (12) :1207-1209.

[12]Shiina S, Fujino H, Uta Y, et al.Relationship of HBsAg sub-types with HBeAg/Anti-Hbe status and chronic liver disea-ses.PartⅠ:Analysis of 1744 HBsAg carriers[J].Am JGastroenterol, 2001, 96 (4) :866-871.

[13]Sumi H, Yokosuka O, Seki N, et al.Influence of hepatitis Bvirus genotypes on the progression of chronic type B liverdiseases[J].Hepatology, 2003, 37 (1) :19-26. (本文编辑:王莹

施引文献

资源附件(0)

访问统计