NK细胞与丙型肝炎

周东方; 胡朝刚; 周俊英

NK细胞与丙型肝炎

河北医科大学第三医院感染科

详细信息

中图分类号: R512.63
计量
- 文章访问数: 4664
- HTML全文浏览量: 66
- PDF下载量: 736
- 被引次数: 0
出版历程
- 出版日期: 2011-12-20

NK cells and hepatitis C

摘要

摘要: 自然杀伤细胞(NK细胞)无需抗原预先致敏,即可直接杀伤某些肿瘤细胞和病毒感染细胞,是人类抗感染免疫及抗肿瘤、清除异己细胞的第一道天然防线。HCV感染的患者NK细胞数量和功能降低可能是造成疾病慢性化的重要原因。本文就NK细胞与丙型肝炎的关系作一综述。
- 杀伤细胞 /
- 肝炎,丙型
Abstract: Natural killer (NK) cell is a lymphocyte without the need for prior sensitization that plays an important role in the rejection of tumors and cells infected by viruses through direct cytolysis, and it is the first line of natural defenses with anti-tumors and anti-infection removing alien cells.In the patients with HCV infection, dysfunction of NK cell can cause persistent viral infection and chronicity of the disease.In this review, we summarized the relationship between NK cell and viral hepatitis C.
- killer cells /
- hepatitis C

HTML全文

参考文献(24)

[1]CohenJ.The scientific challenge of hepatitis C[J].Science, 1999, 285 (5424) :26-30.

[2]Arase H, Arase N, Saito T.Fas-mediated cytotoxicity by freshly isolated natural killer cells[J].J Exp Med, 1995, 181 (3) :1235-1238.

[3]Lanier LL.Up on the tightrope:natural killer cell activation and inhibition[J].Nat Immunol, 2008, 9 (5) :495-502.

[4]Caligiuri M.Human natural killer cells[J].J Blood, 2008, 112 (3) :461-469.

[5]Robertson MJ, Cameron C, Lazo S, et al.Costimulation of human natural killer cell proliferation:role of accessory cyto-kines and cell contact dependent signals[J].Nat Immun, 1997, 15 (5) :213-226.

[6]Choo QL, Richman KH, Han JH, et al.Genetic organization and diversity of the hepatitis C virus[J].Proc Natl Acad Sci U S A, 1991, 88 (6) :2451-2455.

[7]Salazar-Mather TP, Orange JS, Biron CA.Early murine cy-tomegalo-virus (MCMV) infection induces liver natural killer (NK) cell inflammation and protection through macrophage inflammatory protein1α (MIP-1α) -dependent pathways[J].J Exp Med, 1998, 187 (1) :1-14.

[8]Khakoo SL, Thio CL, Martin MP, et al.HLA and NK cell in-hibitory receptor genes in resolving hepatitis C virus infection[J].J Science, 2004, 305 (5685) :872-874.

[9]Amadei B, Urbani S, Cazaly A, et al.Activation of Natural Killer Cells Dring Acute Infection With Hepatitis C virus[J].Gastroenterology, 2010, 138 (4) :1536-1545.

[10]Sandy P, Nathalie B, Christian Drouin.NK cell Activation dur-ing Acute Hepatitis C Virus Infection[J].J Immunol, 2009, 182, 45:18.

[11]Morishima C, Paschal DM, Wang CC, et al.Decreased NK cell frequency in chronic hepatitis C does not affect exvivocy-tolytic killing[J].J Hepatology, 2006, 43 (3) :573-580.

[12]Sène D, Levasseur F, Abel M, et al.Hepatitis C virus (HCV) evades NKG2D-dependent NK cell responses through NS5A-mediated imbalance of inflammatory cyto-kines[J].PLoS Pathog, 2010, 6 (11) :e1001184.

[13]Golden-Mason L, Rosen HR.Natural killer cells:primary target for hepatitis C virus immune evasion strategies?[J].Liver Transpl, 2006, 12 (3) :363-372.

[14]Meier UC, Owen RE, Taylor E, et al.Shared alterations in NK cell frequency, phenotype, and function in chronic human immunodeficiency virus and hepatitis C virus infections[J].J Virol, 2005, 79 (19) :12365-12374.

[15]Dolganiuc A, Chang S, Kodys K, et al.Hepatitis C virus (HCV) core protein-induced monocyte-mediated mechanisms of re-duced IFN-alpha and plasmacytoid dendritic cell loss in chronic HCV infection[J].J Immunol, 2006, 177 (10) :6758-6768.

[16]Yonkers NL, Rodriguez B, Milkovich KA, et al.TLR ligand de-pendent activetionof naive CD4T cells by plasmacytoid dendritic cells is impaired in hepatitis C virus infection[J].J Immunol, 2007, 178 (7) :4436-4444.

[17]Amal F, Mohamed ME, Lobna M, et al.Interferon therapy shifts natural killer subsets among egyptian patients with chronic hepatitis C[J].Braz J Infect Dis, 2010, 14 (4) :398-405.

[18]Gonzalez VD, Falconer K, Michaёlsson J, et al.Expansionof CD56-NK cells in chronic HCV/HIV-1coinfection:rever-sion by antiviral treatment with pegylated IFN-alpha and ribavirin[J].Clin Immunol, 2008, 128 (1) :46-56.

[19]Zarife MA, Reis EA, Carmo TM, et al.Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56-NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CD25High T-cells control potentially viremia in blood donors with HCV[J].J Med Virol, 2009, 81 (1) :49-59.

[20]杨秀华, 刘冰熔, 姜洪池, 等.干扰素α-2b联合利巴韦林治疗慢性丙型肝炎患者肝内免疫细胞的变化[J].中华肝脏病杂志, 2006, 14 (12) :884-886.

[21]Golden-Mason L, Cox AL, Randall JA, et al.Increased natural killer cell cytotoxicity and NKp30expression protects against hepatitis C virus infection in high-risk individuals and inhibits replication in vitro[J].J hepatol, 2010, 52 (5) :1581-1589.

[22]Dessouki O, Kamiya Y, Nagahama H, et al.Chronic hepati-tis C viral infection reduces NK cell frequency and suppresses cytokine secretion:Reversion by anti-viral treatment[J].Biochem Biophys Res Commun, 2010, 393 (2) :331-337.

[23]Golden-Mason L, Castelblanco N, O’Farrelly C, et al.Pheno-typic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infection[J].J Virol, 2007, 81:9292-9298.

[24]Anoma N, Fishman A.NK cells, innate immunity and hepati-tis C infection after liver transplantation[J].J Clin Infect Dis, 2011, 52 (3) :369-377.

施引文献

资源附件(0)

访问统计