上皮-间充质转化对消化系统肿瘤及纤维化作用的研究进展

杨阳; 樊海宁; 邓勇

上皮-间充质转化对消化系统肿瘤及纤维化作用的研究进展

青海大学医学院附属医院肝胆胰外二科

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中图分类号: R575.2
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出版历程
- 出版日期: 2012-04-20

The role of epithelial-mesenchymal transition in gastrointestinal cancer and fibrosis

摘要

摘要: 上皮-间充质转化（EMT）是近年细胞生物学领域的重大发现;在生理学方面,EMT可引起胚胎形成、伤口愈合和组织再生。在病理学方面,能引起组织纤维化、肿瘤发生、发展、转移及耐药性的形成。目前对于EMT的相关研究正成为临床和基础研究领域十分活跃的课题,对于众多疾病的防治具有深远影响。近期一些研究阐明了EMT关于某些疾病的发病基础机制及其主要的调节因子。将EMT机制作为靶向治疗的药物治疗方案可被应用于预防组织纤维化及抑制肿瘤进展方面。在消化系统领域,有许多关于EMT在胃肠道肿瘤、肝脏肿瘤、胰腺肿瘤及肝纤维化方面起到关键性作用的证据。然而,EMT会在不同疾病中表现出不同的变化,而且在许多特殊疾病中EMT的调节因子尚待证实。本文将对目前关于EMT在消化系统领域肿瘤及纤维化方面作用的研究进展作一综述。
- 上皮-间充质转化 /
- 消化系统肿瘤 /
- 肝硬化
Abstract: The epithelial-mesenchymal transition (EMT) is a major discovery of cytobiology in recent years.It plays physiologic roles in the embryogenesis, wound healing, and tissue regeneration.In terms of pathological direction, it causes organ fibrosis, cancer development, progression, metastasis, and chemoresistance.The EMT-related research became a hot topic in clinical and basic research area which has a far-reaching influence on diseases prevention and control.Recently, the underlying mechanism of EMT and numerous EMT regulators have been identified.Pharmaceutical treatment strategies target EMT pathway could be applied for the prevention of tissue fibrosis and cancer progression.In the area of gastroenterology, profuse evidences have been collected about the critical roles of EMT in cancers of the gastrointestinal tract, liver, and pancreas and hepatic fibrosis.However, EMT varies widely among different cancer types, and much remains to be identified about the main regulators of EMT in a specific disease.In this review, we present recent researches regarding the roles of EMT in cancers and organic fibrosis in the area of gastroenterology.
- epithelial-mesenchymal transition /
- digestive system neoplasms /
- liver cirrhosis

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