乙型肝炎重症化的研究现状和展望

王晓晶; 宁琴

乙型肝炎重症化的研究现状和展望

王晓晶,
宁琴

华中科技大学同济医学院附属同济医院感染性疾病研究所

详细信息

中图分类号: R512.62
计量
- 文章访问数: 2421
- HTML全文浏览量: 9
- PDF下载量: 811
- 被引次数: 0
出版历程
- 出版日期: 2012-06-20

Prospect and progression on severe acute exacerbation of chronic hepatitis B

摘要

摘要: <正>重型乙型肝炎是由HBV感染后导致的重型肝炎,是一种因肝细胞大量坏死而出现严重功能损害的临床综合征,其发病凶险,进展迅速,预后不良。我国每年约有20～30万的乙型肝炎患者因重型肝炎等终末期肝病死亡[1]。目前,重症乙型肝炎的发病机制尚不甚明了,临床上仍缺乏敏感、特异和切实可行的综合评估体系,以及特异、有效的治疗靶点和干预手段。近年来,针对乙型肝炎重症化的发病机制、早期临床监测以及防治方法均有不少新的研究成果。
- 肝炎,乙型 /
- 肝炎,重型 /
- T淋巴细胞
- hepatitis B /
- severe hepatitis /
- T-lymphocytes

HTML全文

参考文献(35)

[1] 王新华, 曾跃红.乙型病毒性肝炎的研究现状与问题[J].中华医护杂志, 2007, 4 (9) :833-835.

[2]Yin JH, He YC, Li CZ, et al.Distribution of HBV genotypes andsubgenotypes in patients with chronic hepatitis B, hepatocellularcarcinoma, asymptomatic HBV carriers and its clinical relevance[J].Academic Journal of Second Military Medical University, 2008, 29 (1) :1-5.

[3]You J, Sriplung H, Chongsuvivatwong V, et al.Profile spectrum andsignificance of hepatitis B virus genotypes in chronic HBV-infectedpatient s in Yunnan, China[J].Hepatobiliary Pancreat Dis Int, 2008, 7 (3) :271-279.

[4] Palumbo E.Hepatitis B genotypes and response to antiviral therapy[J].Am J Ther, 2007, 14 (3) :306-309.

[5]Gu X, Yang X, Wang D, et al.Comparison and significance ofspecific and non-specific cellular immunity in patients with chron-ic hepatitis B caused by infection with genotypes B or C of hepatitisB virus[J].Sci China C Life Sci, 2009, 52 (8) :719-723.

[6]Wiegand J, Hasenclever D, Tillmann HL.Should treatment of hep-atitis B depend on hepatitis B virus genotypes?A hypothesis genera-ted from an explorative analysis of published evidence[J].AntivirTher, 2008, 13 (2) :211-220.

[7]Sugiyama M, Tanaka Y, Kato T, et al.Influence of hepatitis B vi-rus genotypes on the intra-and extracellular expression of viralDNA and antigens[J].Hepatology, 2006, 44 (4) :915-924.

[8]Liu CJ, Jeng YM, Chen CL, et al.Hepatitis B virus basal core pro-moter mutation and DNA load correlate with expression of hepatitisB core antigen in patients with chronic hepatitis B[J].J InfectDis, 2009, 199 (5) :742-749.

[9]徐璐.重型乙型肝炎发病机制研究进展[J].生物医学工程学杂志, 2010, 27 (3) :696-701.

[10]佘为民.乙型肝炎病毒变异与重症肝炎关系探讨[J].肝脏, 2004, 9 (2) :121-122.

[11]Guanieri M, Kim KH, Ban GG, et al.Point mutations upstream ofhepatitis B virus core gene affect DNA replication at the step of coreprotein expression[J].J Virol, 2006, 80 (2) :587-595.

[12]王宇明, 汤影子.重型乙型肝炎发病机制研究进展[J].传染病信息, 2008, 21 (2) :68-70, 94.

[13]Zhang Z, Zhang JY, Wherry EJ, et al.Dynamic programmed death1 expression by virus-specific CD8 T cells correlates with the out-come of acute hepatitis B[J].Gastroenterology, 2008, 134 (7) :1938-1949, 1949.el-3.

[14]Lopes AR, Kellam P, Das A, et al.Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection[J].J Clin Invest, 2008, 118 (5) :1835-1845.

[15]Liu X, Shi F, Tien P, et al.Sustained overexpression of PD-1 onCD8+T cells was significantly associated with poor prognosis in pa-tients with HBV-related acute-on-chronic liver failure[J].Hepatology, 2010, 52 (4 Suppl) :1085A.

[16] Zou Y, Chen T, Han M, et al.Increased killing of liver NK cellsby Fas/Fas ligand and NKG2D/NKG2D ligand contributes to hepa-tocyte necrosis in virus-induced liver failure[J].J Immunol, 2010, 184 (1) :466-475.

[17]Chen T, Zhou YY, Zhu L, et al.The novel KCTD9 contributes toimmunologically mediated liver injury through NK cell activation invirus induced liver failure[J].Hepatology, 2010, 52 (4 Suppl) :110-A.

[18]Hiraoka A, Horiike N, Akbar SM, et al.Soluble CD163 in patientswith liver diseases:very high levels of soluble CD163 in patientswith fulminant hepatic failure[J].J Gastroenterol, 2005, 40 (1) :52-56.

[19]Mller HJ, Grnbaek H, Schidt FV, et al.Soluble CD163 fromactivated macrophages predicts mortality in acute liver failure[J].JHepatol, 2007, 47 (5) :671-676.

[20]Marsden PA, Ning Q, Fung LS, et al.The Fgl2/fibroleukin pro-thrombinase contributes to immunologically mediated thrombosis inexperimental and human viral hepatitis[J].J Clin Invest, 2003, 112 (1) :58-66.

[21]Han M, Yan W, Guo W, et al.Hepatitis B virus-induced hFGL2transcription is dependent on c-Ets-2 and MAPK signal pathway[J].J Biol Chem, 2008, 283 (47) :32715-32729.

[22]李维娜, 宁琴.HBV相关肝衰竭的免疫学特征研究进展[J].传染病信息, 2011, 24 (4) :199-202.

[23]韩聚强, 徐小洁.γδT细胞与丙型肝炎病毒、乙型肝炎病毒感染[J].生物技术通讯, 2012, 23 (1) :120-122.

[24]Chen M, Hu P, Peng H, et al.Enhanced peripheralγδT cells cytotox-icity potential in patients with HBV-associated acute-on-chronicliver failure might contribute to the disease progression[J].J Clin Im-munol, 2012, [Epub ahead of print].

[25]Zhang Z, Zou ZS, Fu JL, et al.Severe dendritic cell perturbation is ac-tively involved in the pathogenesis of acute-on-chronic hepatitis B liverfailure[J].J Hepatol, 2008, 49 (3) :396-406.

[26]Zou ZS, Li B, Xu D, et al.Imbalanced intrahepatic cytokine ex-pression of interferon-[gamma]tumor necrosis Factor-[alpha], and interleukin-10 in patients with acute-on-chronic liver fail-ure associated with Hepatitis B virus infection[J].J Clin Gastroen-terol, 2009, 43 (2) :182-190.

[27]白雪帆, 南雪萍.重型肝炎的分子发病机制研究进展[J].临床内科杂志, 2008, 25 (5) , 293-295.

[28]Fisher JE, Mckenzie TJ, Lillegard JB, et al.Sirs mediated by toll-like receptor 4 and kupffer cells in a murine model of ALF[J].Hepatology, 2010, 52 (4 Suppl) :332A.

[29]郑洁, 李进, 于树娜, 等.肝细胞核因子的研究进展[J].医学综述, 2008, 14 (4) :491-493.

[30]Chen EQ, Sun H, Feng P, et al.Study of the expression levels ofHepatocyte nuclear factor 4 alpha and 3 beta in patients with differ-ent outcome of HBV infection[J].Virol J, 2012, 18 (9) :23.

[31]Wu ZG, Yan WM, Guo W, et al.Telbivudine preserves T-helper1 cytokine production and downregulates programmed death ligand 1in a mouse model of viral hepatitis[J].J Viral Hepatitis, 2010, 17 (Suppl 1) :S24-S33.

[32]Gao S, Wang M, Ye H, et al.Dual interference with novel genesmfgl2 and mTNFR1 ameliorates murine hepatitis virus type 3-in-duced fulminant hepatitis in BALB/cJ mice[J].Hum Gene Ther, 2010, 21 (8) :969-977.

[33]He F, Chen EQ, Liu L, et al.Inhibition of hepatitis B Virus repli-cation by hepatocyte nuclear factor 4-alpha specific short hairpinRNA[J].Liver Int, 2012, 32 (5) :742-751.

[34]Zou Y, Chen T, Han MF, et al.Increased killing of liver NK Cellsby Fas/Fas ligand and NKG2D/NKG2D ligand contributes to hepa-tocyte necrosis in virus-induced liver failure[J].J Immunol, 2010, 184, 466-475.

[35]Liu F, Liu ZD, Wu N, et al.Transplanting enodothelial progenitorcells ameliorate carbon tetrachloride-induced liver cirrhosis in rats[J].Liver Transplantation, 2009, 15 (9) :1092-1100.

施引文献

资源附件(0)

访问统计