Features of acute-on-chronic pre-liver failure and establishment of a predictive model for risk of acute-on-chronic liver failure
-
摘要:
<正>肝衰竭(liver failure)是由各种原因所导致的一种严重肝功能失代偿状态。在我国,绝大多数肝衰竭病例是在慢性HBV感染基础上发生的慢加急性肝衰竭(acute-on-chronic liver failure,ACLF),所以HBV相关的ACLF(ACLF-HBV)一直是学界关注和研究的重点。有关肝衰竭的分类、定义与诊断标准,国内外肝病学术界至今尚未达成统一的意见。2005年美国肝病学会(AASLD)将既往无肝病基础者突然出现的肝功能丧失定义为急性肝衰竭(ALF),其标准是:(1)既往无肝硬
-
Key words:
- liver failure /
- acute /
- hepatitis B /
- chronic
-
[1]Polson J, Lee WM.AASLD position paper:The management ofacute liver failure[J].Hepatology, 2005, 41 (5) :1179-1197. [2]Sarin SK, Kumar A, Almeida JA, et al.Acute-on-chronicliver failure:consensus recommendations of the Asian PacificAssociation for the study of the liver (APASL) [J].HepatolInter, 2009, (3) :269-282. [3]中华医学会感染病学分会肝衰竭与人工肝学组.肝衰竭诊疗指南[J].中华肝脏病杂志, 2006, 14 (9) :643-646. [4] 中华医学会传染病与寄生虫病学分会、肝病学分会.病毒性肝炎防治方案[J].中华内科杂志, 2000, 40 (1) :62-68. [5] 中华医学会肝病学分会, 中华医学会感染病学分会.慢性乙型肝炎防治指南 (2010年版) [J].临床肝胆病杂志, 2011, 27 (1) :Ⅰ-ⅩⅥ. [6]洪亮, 叶志勇, 孙庆丰, 等.慢加急性乙型肝炎肝衰竭并发症与预后的关系研究[J].中国微生态学杂志, 2011, 23 (9) :829-831. [7]Montejo González JC, Catalán González M, Meneu Díaz JC, et al.Artificial liver support system in acute liver failure pa-tients waiting liver transplantation[J].Hepatogastroenterolo-gy, 2009, 56 (90) :456-461. [8]张晶.慢加急性肝衰竭临床诊断与治疗研究热点[J].山东医药, 2011, 51 (16) :3-5. [9]Jalan R, Williams R.Acute-on-chronic liver failure:patho-physiological basis of therapeutic options[J].Blood Purif, 2002, 20 (3) :252-261. [10]张南, 陈耀凯, 夏杰, 等.慢性重型乙型肝炎预后影响因素分析及拉米夫定抗病毒治疗对患者生存的影响[J].传染病信息, 2008, 2l (2) :92-94. [11]Wong S, Chan Y.Severe acute exacerbation of chronic hep-atitis B:a unique presentation of a common disease[J].JGastroenterol Hepatol, 2009, 24 (7) :1179-1186. [12]Levy P, Marcellin P, Martinot Peignoux M, et al.Clinical courseof spontaneous reactivation of hepatitis B virus infection in pa-tients with chronic hepatitis B[J].Hepatology, 1990, 12 (3 Pt1) :570-574. [13]Zhang XQ, Jiang L, You JP, et al.Efficacy of short-termdexamethasone therapy in acute-on-chronic pre-liver fail-ure[J].Hepatol Res, 2011, 41 (1) :46-53. [14]刘明, 邓国宏, 谭顺, 等.慢加急性肝衰竭前期临床常规预警指标研究[J].第三军医大学学报, 2012, 34 (8) :772-775. [15]李梦东, 王志新, 顾长海, 等.糖皮质激素对重型肝炎及慢性活动性肝炎的疗效[J].第三军医大学学报, 1985, 7 (2) :159-162. [16]顾长海, 何长清, 汪耕祥, 等.糖皮质类固醇对重型病毒性肝炎前期的疗效[J].中华内科杂志, 1988, 27 (4) :480-482. [17]Fujiwara K, Yasui S, Okitsu K, et al.The requirement for asufficient period of corticosteroid treatment in combinationwith nucleoside analogue for severe acute exacerbation ofchronic hepatitis B[J].J Gastroenterol, 2010, 45 (12) :1255-1262.
计量
- 文章访问数: 3218
- HTML全文浏览量: 7
- PDF下载量: 737
- 被引次数: 0