JAK-STAT信号通路及STAT蛋白在慢性肝病中的研究进展

王艳; 高斌

JAK-STAT信号通路及STAT蛋白在慢性肝病中的研究进展

王艳,
高斌

1. 北京大学第一医院感染疾病科
2. Laboratory of Liver Diseases,National Institute on Alcohol Abuse and Alcoholism,National Institutes of Health,USA

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中图分类号: R575
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出版历程
- 出版日期: 2012-11-20

Functions of signal transducers and activators of transcription (STAT) in the liver

Wang Yan,
Gao Bin

摘要

摘要:
<正>1 JAK-STAT通路及其激活和调控1.1 JAK-STAT通路组成JAKs是一类胞浆内可溶性非受体酪氨酸蛋白激酶,分子量在120～140 kD左右。JAKs具有7个保守的同源结构域（JAK homology domain,JH）JH1～JH7。家族中已发现四个成员,即JAK1、JAK2、JAK3和Tyk2。JAKs的底物为STATs,即信号转导子和转录激活子(signal transduc-
- STAT转录因子类 /
- 干扰素类 /
- 肝炎,丙型,慢性 /
- 肝肿瘤
- STAT transcription factors /
- interferons /
- hepatitis C /
- chronic

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参考文献(60)

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