microRNA在乙型、丙型肝炎中的作用

胡学玲; 范公忍

microRNA在乙型、丙型肝炎中的作用

北京军区总医院全军肝病治疗中心

详细信息

中图分类号: R512.62
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出版历程
- 出版日期: 2012-11-20

Functional role of microRNAs in viral hepatitis infections

摘要

摘要:
近年来,作为基因表达的重要调节因子microRNA(miRNA),以及与这些miRNA关联或调控的各种肝脏疾病,如肝炎、肝纤维化和肝细胞癌(HCC)等方面的研究取得了新进展。许多编码miRNA的基因及其靶标被发现,它们与肝脏疾病的直接或间接的关联性也通过大量的实验研究(包括人体组织)得到确证。病毒性肝炎是由多种不同肝炎病毒引起的一组以肝脏损伤为主的传染病,根据病原学诊断,肝炎病毒至少有5种,但目前最常见的是HBV和HCV感染。本文就miRNA与病毒性肝炎的关系研究进展作一综述。
- 微RNAs /
- 病毒性肝炎
Abstract:
Since their discovery in the 1990s, microRNAs (miRNAs) have been characterized as important regulators of gene expression, mediating normal physiological processes and pathogenesis-related mechanisms, as well as being amenable to exogenous manipulation to elicit therapeutic effects.The roles of miRNAs in liver diseases, such as liver fibrosis, viral hepatitis, and hepatocellular carcinoma (HCC) , have been extensively studied.Many of the liver disease-associated miRNA-encoding genes and their downstream targets have been identified, and their direct or indirect relationship with specific disease types and stages have been confirmed both in vitro and in vivo using animal models and human tissues.Viral hepatitis is one of the most prevalent infectious diseases worldwide and a principal cause of liver damage, liver failure, and mortality associated with liver disease.At least five hepatitis viruses commonly infect humans, but hepatitis B virus (HBV) and hepatitis C virus (HCV) account for the majority of cases.Research efforts aimed at understanding the pathogenesis of and host response to hepatitis viruses have focused on the role of endogenous miRNAs in these processes.This review article presents the recent findings concerning the relationship between miRNA and viral hepatitis and discusses the implications of those findings for future development of miRNA biomarker-based diagnostic, prognostic, and therapeutic strategies.
- microRNAs /
- viral hepatitis

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参考文献(19)

[1]Friedman JM, Jones PA.Micrornas:Critical mediators of differenti-ation, development and disease[J].Swiss Med Wkly, 2009, 139 (33-34) :466-472.

[2]Chen XM.MicroRNA signatures in liver diseases[J].World JGastroenterol, 2009, 15 (14) :1665-1672.

[3]Boutz DR, Collins PJ, Suresh U, et al.A two-tiered approach i-dentifies a network of cancer and liver diseases related genes regula-ted by mir-122[J].J Biol Chem, 2011, 286 (20) :18066-18078.

[4]Davis-Dusenbery BN, Hata A.Mechanisms of control of microrna bio-genesis[J].J Biochem, 2010, 148 (4) :381-392.

[5]Zhang G, Wang Q, Xu R.Therapeutics based on microRNA:anew approach for liver cancer[J].Current Genomics, 2010, 11 (5) :311-325.

[6]Murakami Y, Yasuda T, Saigo K, et al.Comprehensive analysis ofmicyoRNA expresson pattens in hepatocellular carcinoma and non-tumorous tissues[J].Oncogene, 2006, 25 (17) :2537-2545.

[7]Qiao C, Yuan Z, Li J, et al.Liver-specific microrna-122 targetsequences incorporated in aavvectors efficiently inhibits transgeneexpression in the liver[J].Gene Ther, 2010, 18 (4) :403-410.

[8]Chen Y, Shen A, Rider PJ, et al.A liver-specific microRNAbinds to a highly conserved RNA sequence of hepatitis B virus andnegatively regulates viral gene expression and replication[J].FASEB J, 2011, 25 (12) :4511-4521.

[9]马兆龙, 杨炼, 陈立波, 等.miRNA在HBV从感染经由肝硬化到肝癌进程中表达谱的变化[J].世界华人消化杂志, 2009, 17 (20) :2112-2116.

[10]Ji F, Yang B, Peng X, et al.Circulating microRNAs in hepatitis Bvirus-infected patients[J].J Viral Hepat, 2011, 18 (7) :e242-251.

[11]Zhang Y, Jia Y, Zhang R, et al.Plasma microRNA-122 as a bi-omaker for viral-, alcohol-, and chemical-related hepatic disea-ses[J].Clin Chem, 2010, 56 (12) :1830-1838.

[12]Wang CM, Wang Y, Fan CG, et al.miR-29c targets TNFAIP3, inhibits cell proliferation and induces apoptosis in hepatitis B virus-related hepatocellular carcinoma[J].Biochem Biophys Res Com-mun, 2011, 411 (3) :586-592.

[13]Randall G, Panis M, Cooper JD, et al.Celluar cofactors affectinghepatitis C virus infection and replication[J].Proc Natl Acad Sci US A, 2007, 104 (31) :12884-12889.

[14]Henke Jl, Goergen D, Zheng J, et al.micorRNA-122 stimulatestransation of hepatitis Cvirus RNA[J].EMBO J, 2008, 27 (24) :3300-3310.

[15]Narbus CM, Israelow B, Sourisseau M, et al.HepG2 cells expressing mi-croRNA miR-122 support the entire hepatitis C virus life cycle[J].JVirol, 2011, 85 (22) :12087-12092.

[16]Verena B, Mireen FR, Bernd K, et al.Serum miR-122 as a bio-marker of necroinflammation in patients with chronic hepatitis C vi-rus infection[J].Am J Gastroenterol, 2011, 106 (9) :1663-1669.

[17]Silvia C, Anna R, Jorge AM, et al.Circulating microRNAs in pa-tients with chronic hepatitis C and non-alcoholic fatty liver disease[J].PLoS ONE, 2011, 6 (8) :e23937.

[18] Verena B, Oliver W, Mireen FR, et al.Serum MicroRNA-21 asMarker for necroinflammation in hepatitis C patients with and with-out hepatocellular carcinoma[J].PLoS ONE, 2011, 6 (10) :e26971.

[19]Johannes H, Nicolas Z, Mathias H.The parallel universe:microRNAsand their role in chronic hepatitis, liver tissue damage and hepatocarci-noma genesis[J].Swiss Med Wkly, 2011, 141:w13287.

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