磷脂酰肌醇蛋白多糖-3介导的信号通路与肝癌靶向治疗

陈洁; 姚敏; 姚登福

磷脂酰肌醇蛋白多糖-3介导的信号通路与肝癌靶向治疗

南通大学附属医院临床医学研究中心

基金项目:

江苏省卫生科技项目(H2009025)；南通市社会事业创新与示范计划项目(HS2011012)；

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2013-01-20

Role of glypican-3 signaling pathways and therapeutic potential in hepatocellular carcinoma

Research funding:

摘要

摘要:
磷脂酰肌醇蛋白多糖（GPC）-3相关信号通路与肝细胞癌（HCC）发生发展密切相关。GPC-3除用于HCC特异诊断外,靶向GPC-3可明显抑制HCC细胞增殖并诱导凋亡,有望成为HCC的分子靶目标。
- 肝肿瘤 /
- 醇类
Abstract:
Glypican-3 (GPC-3) signaling pathways contribute to the development and progression of hepatocellular carcinoma (HCC) .As a specific diagnostic marker of HCC, GPC-3 may also represent a novel therapeutic target.Recent studies have shown that molecular targeting of GPC-3 can significantly inhibit growth of HCC cells, as well as enhance apoptosis.Here, we discuss the underlying mechanisms of the GPC-3-mediated anti-proliferative and pro-apoptotic effects in HCC, which may help in development of improved GPC-3 targeted therapy.
- liver neoplasms /
- phosphatidylinositols

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