miR-15家族在肝脏疾病中的作用

马丽霞; 韦新焕; 张晶

miR-15家族在肝脏疾病中的作用

首都医科大学附属北京佑安医院人工肝中心

基金项目:

“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项基金资助项目(2012ZX10002004-006)；北京市朝阳区艾滋病和病毒性肝炎等重大传染病综合防治示范区建设研究资助项目(2012ZX10004904)；

详细信息

中图分类号: R575
计量
- 文章访问数: 3552
- HTML全文浏览量: 12
- PDF下载量: 678
- 被引次数: 0
出版历程
- 出版日期: 2013-02-20

Recent perspectives on the role of microRNAs of the miR-15 family in liver disease

Research funding:

摘要

摘要:
微小RNA（miRNA）是一类最新发现的短小内源性非编码RNA,其中miR-15家族生理状态下参与细胞凋亡、分化与周期调控、应激等重要细胞功能活动的调节,而在病理状态下与多种人类疾病如肿瘤、心血管疾病、神经退行性疾病等相关,具有潜在的治疗前景。本文就miR-15家族在肝癌、急性肝衰竭、肝纤维化和慢性肝病中的重要功能及治疗应用前景作一综述。
- 微RNAs /
- 肝炎,慢性 /
- 肝硬化 /
- 肝功能衰竭,急性 /
- 癌,肝细胞
Abstract:
Since their recent discovery, microRNAs (miRNAs) , a class of short endogenous non-coding RNAs, have gained substantial research attention for their critical roles in a broad range of physiologic and pathogenic processes.Under normal physiological conditions, the miR-15 family members regulate several important cellular functions, including apoptosis, cell differentiation, cell cycle, and stress responses.However, under pathological conditions, the miR-15 family members contribute to carcinogenesis, cardiovascular dysfunctions, and neurodegeneration;these activities may represent potentially useful targets of molecular therapeutic strategies.In this review, we summarize and discuss the important functions and promising therapeutic applications of the miR-15 family in liver cancer, acute liver failure, liver fibrosis, and liver damage.
- microRNAs /
- hepatitis /
- chronic /
- liver cirrhosis /
- liver failure

HTML全文

参考文献(30)

[1]Bartel DP.MicroRNAs:genomics, biogenesis, mechanism, and function[J].Cell, 2004, 116 (2) :281-297.

[2]Bartel DP.MicroRNAs:target recognition and regulatory func-tions[J].Cell, 2009, 136 (2) :215-233.

[3]Axtell MJ, Westholm JO, Lai EC.Vive la difference:biogen-esis and evolution of microRNAs in plants and animals[J].Genome Biol, 2011, 12 (4) :221.

[4]Lewis BP, Burge CB, Bartel DP.Conserved seed pairing, often lanked by adenosines, indicates that thousands of humangenes are microRNA targets[J].Cell, 2005, 120 (1) :15-20.

[5]Bargaje R, Hariharan M, Scaria V, et al.Consensus miRNAexpression profiles derived from interplatform normalization ofmicroarray data[J].RNA, 2010, 16 (1) :16-25.

[6]Yue J, Tigyi G.Conservation of miR-15a/16-1 and miR-15b/16-2 clusters[J].Mamm Genome, 2010, 21 (1-2) :88-94.

[7]Benson AB 3rd, Abrams TA, Ben-Josef E, et al.NCCNclinical practice guidelines in oncogy:hepatobiliary cancers[J].J Nat Compr Canc Netw, 2009, 7 (4) :350-391.

[8]Qu KZ, Zhang Ke, Li H, et al.Circulating MicroRNAs as bio-markers for hepatocellular carcinoma[J].J Clin Gastroen-terol, 2011, 45 (4) :355-360.

[9]Chung GE, Yoon JH, Myung SJ, et al.High expression ofmicroRNA-15b predicts a low risk of tumor recurrence fol-lowing curative resection of hepatocellular carcinoma[J].Oncol Rep, 2010, 23 (1) :113-119.

[10]Liu AM, Yao TJ, Wang W.Circulating miR-15b and miR-130b in serum as potential markers for detecting hepatocellu-lar carcinoma:a retrospective cohort study[J].BMJ open, 2012, 2 (2) :e000825.

[11]Huang YH, Lin KH, Chen HC, et al.Identification of postop-erative prognostic MicroRNA predictors in hepatocellular car-cinoma[J].PLoS One, 2012, 7 (5) :e37188.

[12]Skawran B, Steinemann D, Becker T, et al.Loss of 13q isassociated with genes involved in cell cycle and proliferationin dedifferentiated hepatocellular carcinoma[J].Mod Pathol, 2008, 21 (12) :1479-1489.

[13]Tsang WP, Kwok TT.Epigallocatechin gallate up-regulationof miR-16 and induction of apoptosis in human cancer cells[J].J Nutr Biochem, 2010, 21 (2) :140-146.

[14]Tsang TY, Tang WY, Chan JY, et al.P-glycoprotein en-hances radiation-induced apoptotic cell death through theregulation of miR-16 and Bcl-2 expressions in hepatocellu-lar carcinoma cells[J].Apoptosis, 2011, 16 (5) :524-535.

[15]Bottoni A, Piccin D, Tagliati F, et al.miR-15a and miR-16-1 down-regulation in pituitary adenomas[J].J Cell Phys-iol, 2005, 204 (1) :280-285.

[16]Bandi N, Zbinden S, Gugger M, et al.miR-15a and miR-16 are implicated in cell cycle regulation in a Rb dependentmannerand are frequently deleted or down regulated in non-small cell lung cancer[J].Cancer Res, 2009, 69 (13) :5553-5559.

[17]Bonci D, Coppola V, Musumeci M, et al.The miR-15amiR-16-1 cluster controls prostate cancer by targetingmultiple oncogenic activities[J].Nat Med, 2008, 14 (11) :1271-1277.

[18]Linsley PS, Schelter J, Burchard J, et al.Transcripts targetedby the microRNA-16 family cooperatively regulate cell cycleprogression[J].Mol Cell Biol, 2007, 27 (6) :2240-2252.

[19]Wu G, Yu F, Xiao Z, et al.Hepatitis B virus X protein downreg-ulates expression of the miR-16 family in malignant hepato-cytes in vitro[J].Br J of Cancer, 2011, 105 (1) :146-153.

[20] Xu T, Zhu Y, Xiong Y, et al.MicroRNA-195 suppresses tu-morigenicity and regulates G1/S transition of human hepatocel-lular carcinoma cells[J].Hepatology, 2009, 50 (1) :113-121.

[21]Wu Z, Han M, Chen T, et al.Acute liver failure:mecha-nisms of immune-mediated liver injury[J].Liver Int, 2010, 30 (6) :782-794.

[22] An F, Gong B, Wang H.miR-15b and miR-16 regulateTNF mediated hepatocyte apoptosis via BCL2 in acute liverfailure[J].Apoptosis, 2012, 17 (7) :702-716.

[23]Li D, Friedman SL.Liver fibrogenesis and the role of hepaticstellate cell:new insights and prospects for therapy[J].JGastrcenterol Hepatol, 1999, 14 (7) :618-633.

[24]Guo CJ, Pan Q, Li DG, et al.miR-15b and miR-16 areimplicated in activation of the rat hepatic stellate cell:An es-sential role for apoptosis[J].J Hepatol, 2009, 50 (4) :766-778.

[25]Guo CJ, Pan Q, Jiang B, et al.Effects of upregulated ex-pression of microRNA-16 on biological properties of culture-activated hepatic stellate cells[J].Apoptosis, 2009, 14 (11) :1331-1340.

[26]Peng X, Li Y, Walters KA, et al.Computational identification ofhepatitis C virus associated microRNA-mRNA regulatory mod-ules in human livers[J].BMC Genomics, 2009, 10:373.

[27]Silvia C, Anna R, Jorge A, et al.Circulating microRNAs inpatients with chronic hepatit C and non-alcoholic fatty liverdisease[J].PLoS One, 2011, 6 (8) :e23937.

[28]Zhang XY, Ni M, Chen SS, et al.Endogenous liver microRNAregulates HBV gene expression and replication[J].J Med MolBiol, 2008, 5 (3) :189-193. (in Chinese) 张小勇, 倪明, 陈姗姗, 等.肝脏内源性microRNA调控乙型肝炎病毒基因的表达与复制[J].医学分子生物学杂志, 2008, 5 (3) :189-193.

[29]Otsuka M, Aizaki H, Kato N, et al.Differential cellular geneexpression induced by hepatitis B and C viruses[J].BBRC, 2003, 300 (2) :443-447.

[30]Liu Y, Zhao JJ, Wang CM, et al.Altered expression profilesof microRNAs in a stable hepatitis B virus expressing cell line[J].CMJ, 2009, 122 (1) :10-14.

施引文献

资源附件(0)

访问统计