90例原发性肝癌临床特点分析

朱伟; 李明; 金满春

90例原发性肝癌临床特点分析

苏州市第五人民医院传染科

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中图分类号: R735.7
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出版历程
- 出版日期: 2013-06-20

Clinical features of primary hepatic carcinoma: An analysis of 90 cases

Department of Infectious Diseases, Suzhou Fifth People′s Hospital

摘要

摘要:
目的探讨原发性肝癌（PHC）的临床特点,提高该病的早期诊断水平。方法对90例PHC住院患者的资料进行回顾性分析,同时收集同期住院的45例肝硬化患者的资料进行对比,以45例健康体检者为对照。收集患者的一般资料,肿瘤指标[甲胎蛋白（AFP）及α-L-岩藻酸糖苷酸（AFU）],生化指标[HBV标志物、TBil、ALT、Alb、前白蛋白（PAB）、ALP、GGT、HBV DNA]及影像学资料。组间比较计量资料采用t检验及方差分析,计数资料采用卡方检验。结果 90例患者首发症状各异,缺乏特异性,中晚期患者居多。HBV总感染率为88.9%,感染模式以HBsAg阳性、抗-HBe阳性、抗-HBc阳性为主,占55.6%,40～69岁为高发年龄段,占76.7%。PHC组与肝硬化组比较两组间HBV DNA定量、TBil、ALT值差异无统计学意义,但Alb与PAB,GGT及ALP肝癌组明显高于肝硬化组（P<0.01）。PHC患者AFP和AFU水平明显高于肝硬化组及健康对照组,差异有统计学意义（P<0.001）,联合检测较两者单项检测阳性率高（P<0.05）。结论应通过对高危人群定期随访,及时...
- 原发性肝癌 /
- 甲胎蛋白类 /
- α-L-岩藻酸糖苷酸 /
- 早期诊断
Abstract:
Objective To investigate the clinical features of primary hepatic carcinoma (PHC) and to improve the early diagnosis of the disease.Methods A retrospective analysis was performed on the clinical data of 90 inpatients with PHC (PHC group) ;the clinical data of 45 patients with liver cirrhosis (LC) who were hospitalized in the same period (LC group) were also collected for comparison, and 45 healthy persons in physical examination were selected as a control group.The collected data of patients included general information, tumor markers: alpha-fetoprotein (AFP) and alpha-L-fucosidase (AFU) , biochemical indices: hepatitis B virus (HBV) markers, total bilirubin (TBil) , alanine aminotransferase (ALT) , albumin (Alb) , prealbumin (PAB) , alkaline phosphatase (ALP) , gamma-glutamyl transpeptidase (GGT) , and HBV DNA, and imaging findings.These groups were compared by t-test and analysis of variance (for measurement data) and chi-square test (for numeration data) .Results The 90 PHC patients had different initial symptoms, without specificity, and most cases were in advanced stage.The total HBV infection rate was 88.9%, and the hepatitis B surface antigen (HBsAg) -positive, hepatitis B e antibody (HBeAb) -positive, and hepatitis B c antibody (HBcAb) -positive cases accounted for 55.6% of all infected ones.The 40-69 years age group accounted for 76.7% of all PHC cases.There were no significant differences in HBV DNA level and serum TBil and ALT levels between the PHC group and LC group, but the PHC group had significantly higher serum Alb, PAB, GGT, and ALP levels than the LC group (P<0.01) .The serum AFP and AFU levels were significantly higher in PHC group than in LC group and control group (P<0.001) , and the positive rate in joint detection of AFP and AFU was significantly higher than that in detection of either AFP or AFU (P<0.05) .Conclusion Regular follow-up should be performed in people with high risk of PHC to find clinical symptoms in time, and various tumor markers and diagnostic tools, such as ultrasound, angiography, CT, and MRI, can be used to increase the early detection rate of PHC.
- primary hepatic carcinoma /
- alpha-fetoproteins /
- alpha-L-fucosidase /
- early diagnosis

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参考文献(8)

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