门静脉血栓动物模型的建立和应用

刘壮; 陈纪宏; 祁兴顺; 许向波; 诸葛宇征

doi:10.12449/JCH240105

门静脉血栓动物模型的建立和应用

DOI: 10.12449/JCH240105

刘壮^{1, 2},
陈纪宏^{1, 3},
祁兴顺^1, , ,,
许向波¹,
诸葛宇征⁴

1.
北部战区总医院消化内科，沈阳 110840
2.
中国医科大学研究生院，沈阳 110122
3.
大连医科大学研究生院，辽宁大连 116044
4.
南京大学医学院附属鼓楼医院消化内科，南京 210008

基金项目:

国家自然科学基金 (8227034094)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：刘壮负责查阅文献、资料分析、撰写论文；诸葛宇征、陈纪宏、许向波参与修改论文；祁兴顺指导撰写文章并最后定稿。

详细信息

通信作者:
祁兴顺， xingshunqi@126.com （ORCID： 0000-0002-9448-6739）

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出版历程
- 收稿日期: 2023-11-22
- 录用日期: 2023-11-30
- 出版日期: 2024-01-23

Establishment and application of animal models for portal vein thrombosis

Zhuang LIU^{1, 2},
Jihong CHEN^{1, 3},
Xingshun QI^{1
, ,
,},
Xiangbo XU¹,
Yuzheng ZHUGE⁴

1.
Department of Gastroenterology，General Hospital of Northern Theater Command，Shenyang 110840，China
2.
Graduate School of China Medical University，Shenyang 110122，China
3.
Graduate School，Dalian Medical University，Dalian，Liaoning 116044，China
4.
Department of Gastroenterology，Affiliated Drum Tower Hospital of Nanjing University Medical School，Nanjing 210008，China

Research funding:

National Natural Science Foundation of China (8227034094)

More Information

Corresponding author: QI Xingshun， xingshunqi@126.com （ORCID： 0000-0002-9448-6739）

摘要

摘要: 门静脉血栓（PVT）是指在肝外门静脉主干和/或肝内门静脉分支内发生的血栓栓塞。PVT是由多种因素共同作用的结果，但其发病机制尚未完全阐明。建立动物模型是研究PVT病理生理机制的重要方法。本文根据不同的动物种类，对现有PVT动物模型的建立方法、原理、优缺点和应用情况进行综述。
- 门静脉血栓 /
- 疾病模型，动物 /
- 发病机制
Abstract: Portal vein thrombosis （PVT） refers to thromboembolism that occurs in the extrahepatic main portal vein and/or intrahepatic portal vein branches. PVT is the result of the combined effect of multiple factors， but its pathogenesis remains unclear. Animal models are an important method for exploring the pathophysiological mechanism of PVT. Based on the different species of animals， this article reviews the existing animal models of PVT in terms of modeling methods， principles， advantages and disadvantages， and application.
- Portal Vein Thrombosis /
- Disease Models， Animal /
- Pathogenesis

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