慢加急性肝衰竭动物模型研究现状

刘韦; 白浪

doi:10.12449/JCH240131

慢加急性肝衰竭动物模型研究现状

DOI: 10.12449/JCH240131

刘韦,
白浪^, ,

四川大学华西医院感染性疾病中心，成都 610041

基金项目:

四川大学华西医院学科卓越发展1·3·5工程项目 (ZYJC21014)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：刘韦起草论文；白浪负责拟定写作思路，论文审阅修改。

详细信息

通信作者:
白浪， pangbailiang@163.com （ORCID： 0000-0001-5042-4336）

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出版历程
- 收稿日期: 2023-05-19
- 录用日期: 2023-06-19
- 出版日期: 2024-01-23

Current research status of animal models for acute-on-chronic liver failure

Wei LIU,
Lang BAI^{,
,}

Center of Infectious Diseases，West China Hospital，Sichuan University，Chengdu 610041，China

Research funding:

The 1·3·5 Project for Disciplines of Excellence of West China Hospital of Sichuan University (ZYJC21014)

More Information

Corresponding author: Bai Lang， pangbailiang@163.com （ORCID： 0000-0001-5042-4336）

摘要

摘要: 慢加急性肝衰竭病情复杂、进展快、病死率高，其发病机制、病因等仍有待进一步研究阐明。而通过慢加急性肝衰竭动物模型的建立，不仅能为慢加急性肝衰竭的发病机制研究提供良好的基础，而且能为临床治疗提供实验依据。通过对相关文献的梳理，总结了目前常用的建立慢加急性肝衰竭动物模型的方法，包括CCl₄联合脂多糖（LPS）/D-氨基半乳糖胺法、硫代乙酰胺联合LPS法、血清白蛋白法、胆管结扎术法等。通过分析各种动物模型的特点，为进一步探索更理想的动物模型提供文献基础和实验依据。
- 肝疾病 /
- 慢加急性肝功能衰竭 /
- 模型，动物
Abstract: Acute-on-chronic liver failure has complex conditions， rapid progression， and a high mortality rate， and further studies are still needed to clarify its pathogenesis and etiology. The establishment of animal models for acute-on-chronic liver failure can not only provide a good basis for exploring the pathogenesis of acute-on-chronic liver failure， but also provide an experimental basis for clinical treatment. Through a literature review， this article summarizes the methods commonly used to establish the animal models of acute-on-chronic liver failure， including carbon tetrachloride combined with LPS/GaIN， thioacetamide combined with LPS， serum albumin， and bile duct ligation. This article analyzes the characteristics of various animal models， so as to provide documentary and experimental bases for further exploration of more ideal animal models.
- Liver Diseases /
- Acute-On-Chronic Liver Failure /
- Models， Animal

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