慢性HBV感染与代谢功能障碍基础研究： 当前进展与争议

余博容; 陈源文

doi:10.12449/JCH240302

慢性HBV感染与代谢功能障碍基础研究：当前进展与争议

DOI: 10.12449/JCH240302

余博容,
陈源文^, ,

复旦大学附属华东医院消化内科，上海 200040

基金项目:

国家自然科学基金面上项目 (82270620);

上海市科学技术委员会项目 (22140901500)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：余博容负责文献检索、撰写文章；陈源文负责设计文章框架、修改和审校文章。

详细信息

通信作者:
陈源文， chenywhdgi@fudan.edu.cn （ORCID： 0000-0003-4210-007X）

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出版历程
- 收稿日期: 2023-11-21
- 录用日期: 2023-12-26
- 出版日期: 2024-03-20

Basic research on chronic hepatitis B virus infection and metabolic dysfunction： Advances and controversies

Borong YU,
Yuanwen CHEN^{,
,}

Department of Gastroenterology，Huadong Hospital Affiliated to Fudan University，Shanghai 200040，China

Research funding:

General Project of National Natural Science Foundation of China (82270620);

Project of Science and Technology Commission of Shanghai Municipality (22140901500)

More Information

Corresponding author: CHEN Yuanwen， chenywhdgi@fudan.edu.cn （ORCID： 0000-0003-4210-007X）

摘要

摘要: HBV被认为是一种“代谢病毒”，能影响多种代谢生命活动。慢性HBV感染与各种类型代谢功能障碍存在关联但仍无明确定论，对慢性HBV感染与代谢综合征、糖尿病、代谢相关脂肪性肝病等以代谢紊乱为特征的疾病之间相关性的机制仍知之甚少。目前主流观点认为，源自HBV基因组的HBx蛋白可能为HBV感染后介导机体代谢变化的重要环节，HBx可通过调节PPARγ、C/EBPα、SREBP和FATP2等蛋白的表达，影响机体糖、脂等物质的代谢，引起相关代谢功能障碍。非酒精性脂肪性肝病是代谢功能障碍在肝脏的最重要表现形式，由于其与HBV感染均可导致肝损伤，二者相互作用的研究备受关注，目前其关联仍存在较多争议，有待进一步探索。因此，本文详细阐述了当前慢性HBV感染与代谢功能障碍的相关研究进展，为后续的进一步研究提供思路。
- 乙型肝炎病毒 /
- 代谢综合征 /
- 非酒精性脂肪性肝病
Abstract: Hepatitis B virus （HBV） is considered a “metabolic virus” that can influence a variety of metabolic processes. There is still a lack of definite conclusion on the association between chronic HBV infection and the various types of metabolic dysfunction， and little is known about the mechanism of the association of chronic HBV infection with the diseases characterized by metabolic disorder， such as metabolic syndrome， diabetes， and metabolic associated fatty liver disease. Currently it is believed that hepatitis B x gene （HBx）， derived from HBV genome， might play an important role in mediating systemic metabolic alterations after HBV infection， and HBx influences the metabolism of carbohydrates and lipids and causes metabolic dysfunction by retgulating the expression profiles of the key proteins such as PPARγ， C/EBPα， SREBP， and FATP2. Nonalcoholic fatty liver disease （NAFLD） is the most severe manifestation of metabolic dysfunction in the liver， and since both NAFLD and HBV infection can cause liver injury， the research on the interaction between them has attracted more and more attention， with controversies requiring further exploration. Therefore， this article elaborates on the research advances in chronic HBV infection and metabolic dysfunction， so as to provide ideas for subsequent studies.
- Hepatitis B Virus /
- Metabolic Syndrome /
- Non-alcoholic Fatty Liver Disease

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