慢性HBV感染与代谢功能障碍的流行病学与临床转归

黄娇凤; 郑琦

doi:10.12449/JCH240303

慢性HBV感染与代谢功能障碍的流行病学与临床转归

DOI: 10.12449/JCH240303

黄娇凤,
郑琦^, ,

福建医科大学附属第一医院肝内科，福州 350004

基金项目:

国家自然基金青年科学基金项目 (82300652);

福建省自然科学基金 (2022J01700);

福建省肝病与肠道疾病临床医学研究中心 (2021Y2006)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：黄娇凤负责撰写论文；郑琦负责指导、修改及审阅论文。

详细信息

通信作者:
郑琦， bei0825@163.com （ORCID： 0000-0001-8006-7069）

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出版历程
- 收稿日期: 2024-01-09
- 录用日期: 2024-01-28
- 出版日期: 2024-03-20

Epidemiology and clinical outcome of chronic hepatitis B virus infection and metabolic dysfunction

Jiaofeng HUANG,
Qi ZHENG^{,
,}

Department of Hepatology，The First Affiliated Hospital of Fujian Medical University，Fuzhou 350004，China

Research funding:

National Natural Science Foundation of China Young Scientist Fund (82300652);

Natural Science Foundation of Fujian Province (2022J01700);

Clinical Research Center for Liver and Intestinal Diseases of Fujian Province (2021Y2006)

More Information

Corresponding author: ZHENG Qi， bei0825@163.com （ORCID： 0000-0001-8006-7069 ）

摘要

摘要: 慢性HBV感染是一种全球性公共卫生问题，是我国肝纤维化、肝硬化、肝衰竭及原发性肝癌的主要原因。随着人们生活水平的提高及饮食结构的改变，非酒精性脂肪性肝病（NAFLD）发病率也逐渐升高。基于人群的研究发现HBV感染可影响NAFLD的发生，其中机制仍不明确。肝脂肪变性也会影响HBV血清病原学标志物的表达，合并NAFLD或其他代谢功能障碍会增加HBV感染者肝纤维化、肝硬化及肝癌的风险。慢性HBV感染与代谢障碍密切相关，未来需要更多研究进一步阐明相关机制，为临床诊疗提供理论依据。
- 乙型肝炎病毒 /
- 非酒精性脂肪性肝病 /
- 代谢障碍
Abstract: Chronic hepatitis B virus （HBV） infection is a worldwide public health issue and a leading cause of liver fibrosis， liver cirrhosis， liver failure， and primary liver cancer in China. The incidence rate of nonalcoholic fatty liver disease （NAFLD） is gradually increasing with the improvement in the living standards of people and the changes in dietary structure. Population-based studies have found that HBV infection can influence the development of NAFLD， but the mechanism remains unknown. Hepatic steatosis can also influence the expression of HBV serum pathogenic indicators， and its combination with NAFLD and other metabolic dysfunction diseases can increase the risk of liver fibrosis， liver cirrhosis， and liver cancer. Chronic HBV infection is closely associated with metabolic dysfunction， and more studies are needed in the future to better understand related mechanisms， so as to provide a theoretical foundation for clinical diagnosis and treatment.
- Hepatitis B Virus /
- Non-alcoholic Fatty Liver Disease /
- Metabolic Dysfunction||

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参考文献(46)

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