嗜黏蛋白阿克曼菌在非酒精性脂肪性肝病中的作用

郑立婷; 汪哲; 陈玉春; 刘珊山; 解有成; 李初谊; 于晓辉

doi:10.12449/JCH240326

嗜黏蛋白阿克曼菌在非酒精性脂肪性肝病中的作用

DOI: 10.12449/JCH240326

郑立婷^{1, 2},
汪哲^{1, 2},
陈玉春¹,
刘珊山^{1, 2},
解有成^{1, 2},
李初谊¹,
于晓辉^1, , ,

1.
中国人民解放军联勤保障部队第九四〇医院消化内科，兰州 730050
2.
甘肃中医药大学第一临床医学院，兰州 730000

基金项目:

甘肃省非感染性肝病临床医学研究中心 (21JR7RA017);

联勤保障部队第九四〇医院肝病临床医学研究中心 (2021yxky079);

甘肃省卫健委科研管理项目 (GSWSKY2021-047)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：郑立婷负责撰写论文；汪哲、陈玉春、刘珊山、解有成负责查阅、归纳文献；于晓辉、李初谊负责指导撰写，修改论文。

详细信息

通信作者:
于晓辉， yuxiaohui528@126.com （ORCID： 0000-0002-8633-3281）

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出版历程
- 收稿日期: 2023-08-08
- 录用日期: 2023-08-30
- 出版日期: 2024-03-20

Role of Akkermansia muciniphila in nonalcoholic fatty liver disease

Liting ZHENG^{1, 2},
Zhe WANG^{1, 2},
Yuchun CHEN¹,
Shanshan LIU^{1, 2},
Youcheng XIE^{1, 2},
Chuyi LI¹,
Xiaohui YU^{1
, ,
,}

1.
Department of Gastroenterology，The 940th Hospital of Joint Logistic Support Force of PLA，Lanzhou 730050，China
2.
The First Clinical Medical College of Gansu University of Chinese Medicine，Lanzhou 730000，China

Research funding:

Gansu Province Clinical Research Center for Noninfectious Liver Diseases (21JR7RA017);

Liver Disease Clinical Medicine Research Center of the 940th Hospital of Joint Service Support Force (2021yxky079);

Scientific Research Management Project of Gansu Province Health Commission (GSWSKY2021-047)

More Information

Corresponding author: YU Xiaohui， yuxiaohui528@126.com （ORCID： 0000-0002-8633-3281）

摘要

摘要: 非酒精性脂肪性肝病（NAFLD）已成为全球最常见的慢性肝病，同时也是发生肝硬化和肝细胞癌的主要原因之一，因此及时遏止NAFLD的发生发展尤为重要，但由于其复杂的发病机制，目前尚无有效的根治手段。嗜黏蛋白阿克曼菌（Akk菌）作为新一代益生菌，能够改善机体代谢紊乱。越来越多的研究表明，Akk菌对代谢性疾病，尤其是NAFLD有潜在的治疗作用。因此，本文就Akk菌在NAFLD中的作用机制作简要综述，旨在为NAFLD的治疗改进和开创新疗法提供新思路。
- 非酒精性脂肪性肝病 /
- 阿克曼菌属 /
- 治疗学
Abstract: Nonalcoholic fatty liver disease （NAFLD） has become the most common chronic liver disease in the world， and it is also one of the main causes of liver cirrhosis and hepatocellular carcinoma， so it is particularly important to curb the development and progression of NAFLD in a timely manner. However， due to its complex pathogeneses， there are currently no effective methods for radical treatment. As a new generation of probiotics， Akkermansia muciniphila （Akk bacteria） can improve metabolic disorders of the body， and more and more studies have shown that Akk bacteria have a potential therapeutic effect on metabolic diseases， especially NAFLD. Therefore， this article briefly reviews the mechanism of action of Akk bacteria in NAFLD， in order to provide new ideas for improving the treatment of NAFLD and creating new therapies.
- Non-alcoholic Fatty Liver Disease /
- Akkermansia /
- Therapeutics

HTML全文

图 1 Akk菌在NAFLD中的作用机制

注： JNK，c-Jun氨基末端激酶；LKB1，肝激酶B1；AMPK，单磷酸腺苷活化蛋白激酶。

Figure 1. The mechanism of Akkermansia muciniphila in NAFLD

下载: 全尺寸图片幻灯片

表 1 Akk菌在多种疾病中的作用

Table 1. The role of Akkermansia muciniphila in various diseases

研究疾病	作用机制	参考文献
腹泻	结肠固有层腺体紊乱明显减轻，杯状细胞增多，炎性细胞浸润减少	［16］
早衰综合征	肠道TFF3、抗菌肽Reg3表达上调，B淋巴细胞、巨噬细胞数量增多，CD80⁺B淋巴细胞、CD273^-B淋巴细胞、Ly6 Cin单核细胞减少	［18-19］
酒精性肝病	杯状细胞数量增加、紧密连接蛋白claudin-3和occludin表达上调	［20］
阿尔茨海默病	结肠黏液细胞的数量增加，血清DAO水平降低	［22］
伤寒	紧密连接蛋白ZO-1、claudin-4及抗菌肽Reg3、NLRP3表达上调，活性氧、NO和IL-1β水平增加	［23］

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