何首乌致肝损伤的信号通路及其作用机制

梁子晗; 李佳辉; 程爽; 袁卓雅; 荣文雅; 刘亚杰; 郝玉洁; 王睿林

doi:10.12449/JCH240332

何首乌致肝损伤的信号通路及其作用机制

DOI: 10.12449/JCH240332

1.
河南中医药大学第一临床医学院，郑州 450000
2.
南方医科大学中医药学院，广州 510405
3.
解放军总医院第五医学中心中医肝病科，北京 100039

基金项目:

国家自然科学基金面上项目 (81673806);

中国医药教育协会2020重大科学攻关问题和医药技术难题 (2020KTY001)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：梁子晗负责课题设计，资料分析，撰写论文；李佳辉、程爽、袁卓雅、荣文雅、刘亚杰、郝玉洁参与收集数据，修改论文；王睿林负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
王睿林， wrl7905@163.com （ORCID： 0000-0002-7129-016X）

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- 被引次数: 0
出版历程
- 收稿日期: 2023-07-08
- 录用日期: 2023-08-21
- 出版日期: 2024-03-20

Mechanism of action of Polygonum multiflorum in inducing liver injury： A study based on signaling pathways

1.
First Clinical Medical College of Henan University of Chinese Medicine，Zhengzhou 450000，China
2.
School of Traditional Chinese Medicine，Southern Medical University，Guangzhou 510405，China
3.
Department of Traditional Chinese Medicine Hepatology，The Fifth Medical Center of PLA General Hospital，Beijing 100039，China

Research funding:

National Natural Science Foundation of China （General Program） (81673806);

Major Scientific and Technological Issues and Challenges in Medicine and Pharmacy 2020 by the China Association of Medical Education (2020KTY001)

More Information

Corresponding author: WANG Ruilin， wrl7905@163.com （ORCID： 0000-0002-7129-016X）

摘要

摘要: 何首乌是一种临床常用的补益类中草药，相关肝损伤事件近年来被频繁报道，其安全性问题逐渐引起国内外关注。本文梳理近年来何首乌致药物性肝损伤信号通路及作用机制的研究进展，基于信号通路角度，为临床正确合理应用何首乌提供新思路。现有研究证据表明，何首乌参与调控多条信号通路，通过破坏线粒体功能、加重胆汁酸淤积、诱发免疫应激、氧化应激、内质网应激等多种途径导致肝细胞死亡，多靶点、多途径、多层次诱导药物性肝损伤的发生发展。
- 何首乌 /
- 化学性与药物性肝损伤 /
- 信号传导
Abstract: Polygonum multiflorum （PM）， a commonly used Chinese herbal medicine in clinical practice， has been associated with frequent reports of liver injury in recent years， and the medication safety of PM has attracted more and more attention in China and globally. This article reviews the recent research advances in the signaling pathways and mechanisms of PM in causing drug-induced liver injury （DILI） and aims to provide new ideas for the proper and rational use of PM in clinical practice. The results show that PM is involved in the regulation of various signaling pathways， and it leads to the death of hepatocytes by destroying mitochondrial function， exacerbating bile acid accumulation， and inducing immune response， oxidative stress， and endoplasmic reticulum stress， thereby inducing the development and progression of DILI through multiple targets， pathways， and levels.
- Polygoni Multiflori Radix /
- Chemical and Drug Induced Liver Injury /
- Signal Transduction

HTML全文

图 1 线粒体介导的细胞死亡机制

注： Bid， BH3相互作用域死亡激动剂；tBid， Bid的截短形式；Bmf，Bcl-2修饰因子；Bim，Bcl-2相互作用的模块。^{［ 9］}

Figure 1. Mitochondria-mediated cellular death mechanism^［9］

下载: 全尺寸图片幻灯片

图 2 线粒体介导的DILI机制^［7］

Figure 2. Mechanism of mitochondria-mediated DILI^［7］

下载: 全尺寸图片幻灯片

图 3 FXR维护胆汁稳态机制

Figure 3. Mechanism of FXR-maintained bile homeostasis

下载: 全尺寸图片幻灯片

图 4 PM致DILI信号通路

Figure 4. Signaling pathways of polygonum multiflorum-induced DILI

下载: 全尺寸图片幻灯片

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