氨基酸代谢在非酒精性脂肪性肝病中的作用机制

张慧; 谭明; 程胜桃; 陈娟

doi:10.12449/JCH240427

氨基酸代谢在非酒精性脂肪性肝病中的作用机制

DOI: 10.12449/JCH240427

重庆医科大学感染性疾病分子生物学教育部重点实验室，重庆 010000

基金项目:

国家自然科学基金面上项目 (82273423);

国家自然科学基金青年基金 (82202501)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：张慧负责查阅文献，撰写论文；谭明、程胜桃参与修改文章内容；陈娟指导文章撰写及修改，校阅论文。

详细信息

通信作者:
陈娟， chenjuan2014@cqmu.edu.cn （ORCID： 0000-0001-6920-7972）

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出版历程
- 收稿日期: 2023-08-01
- 录用日期: 2023-10-07
- 出版日期: 2024-04-25

Mechanism of amino acid metabolism in nonalcoholic fatty liver disease

Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education，Chongqing Medical University，Chongqing 010000，China

Research funding:

General Project of National Natural Science Foundation of China (82273423);

Youth Fund of National Natural Science Foundation of China (82202501)

More Information

Corresponding author: CHEN Juan， chenjuan2014@cqmu.edu.cn （ORCID： 0000-0001-6920-7972）

摘要

摘要: 非酒精性脂肪性肝病（NAFLD）是全球最普遍的慢性肝病之一，影响全球约1/4的人口，预计到2030年将成为肝移植的主要适应证。NAFLD可导致包括支链氨基酸在内的多种氨基酸水平显著异常，进而促进NAFLD的发生发展。提示除葡萄糖代谢和脂质代谢外，氨基酸代谢也在NAFLD疾病进展中发挥了重要作用。为系统了解氨基酸代谢在NAFLD中的作用及其机制，本文针对氨基酸代谢在NAFLD中的研究进展进行了综述。拟探讨氨基酸代谢在NAFLD疾病进展中发挥的作用及其相关机制，为临床防治提供思路和理论依据。
- 非酒精性脂肪性肝病 /
- 氨基酸类 /
- 代谢组学
Abstract: Nonalcoholic fatty liver disease （NAFLD） is one of the most prevalent chronic liver diseases in the world， affecting about one quarter of the global population， and it is estimated that NAFLD will become the main indication for liver transplantation by 2030. NAFLD can lead to significant abnormalities in the levels of a variety of amino acids including branched-chain amino acids， thereby promoting the development and progression of NAFLD. These results suggest that in addition to glucose and lipid metabolism， amino acid metabolism also plays an important role in the progression of NAFLD. In order to systematically understand the role and mechanism of amino acid metabolism in NAFLD， this article reviews the research advances in amino acid metabolism in NAFLD. This article aims to explore the role and mechanism of amino acid metabolism in the progression of NAFLD， so as to provide ideas and a theoretical basis for clinical prevention and treatment.
- Non-alcoholic Fatty Liver Disease /
- Amino acids /
- Metabolomics

HTML全文

表 1 NAFLD患者血浆氨基酸变化的代谢组学

Table 1. Metabolomics of plasma amino acid changes in patients with non-alcoholic fatty liver disease

文献	年份	ALA	ASN	ASP	CYS	GLN	GLU	GLY	HIS	ILE	LEU	LYS	PHE	PRO	SER	TRP	TYR	VAL
Yamakado等^［6］	2017	+						-	+	+	+	+	+	+	-	+	+	+
Gaggini等^［7］	2017	+					+	-		+		+					+	+
Pietzner等^［8］	2018	+					+	-		+	+		+	+	-	+	+	+
Hasegawa等^［9］	2020	+	-	+	+		+	-	+	+	+	+	+	+	-	+	+	+
Kaikkonen等^［10］	2017	+				-		-		+	+		+				+	+
Grzych等^［11］	2020									+	+
Goffredo等^［12］	2017						+			+	+	+				+		+
Chashmniam等^［13］	2019					-		-		+				+	-		+	+
注：+和-分别代表NAFLD患者与健康对照者血浆氨基酸水平的显著增加或减少。ALA，丙氨酸；ASN，天冬酰胺；ASP，天冬氨酸；CYS，半胱氨酸；GLN，谷氨酰胺；GLU，谷氨酸；GLY，甘氨酸；HIS，组氨酸；ILE，异亮氨酸；LEU，亮氨酸；LYS，赖氨酸；PHE，苯丙氨酸；PRO，脯氨酸；SER，丝氨酸；TRP，色氨酸；TYR，酪氨酸；VAL，缬氨酸。

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参考文献(63)

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