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不同来源的细胞外囊泡在肝细胞癌发生进展中的作用
DOI: 10.12449/JCH240630
利益冲突声明：本文不存在任何利益冲突。
作者贡献声明：史婷婷负责论文撰写与修改；张润兵、伍杨、张亚妮负责论文修改及审阅；朱玲玲、高春、江晶晶负责数据收集；张久聪、郑晓凤等负责拟定写作思路，指导撰写文章并最后定稿。
Role of extracellular vesicles of different origins in the development and progression of hepatocellular carcinoma
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摘要: 肝细胞癌（HCC）是最常见的原发性肝癌类型，也是癌症相关死亡的第三大原因，严重威胁人体健康，成为目前亟待解决的临床难题。细胞外囊泡（EV）是一种含有多种成分的膜囊泡，在HCC的发生和进展中发挥着重要作用，本文通过总结不同来源的EV对HCC的影响，分析EV对HCC的作用机制，以期为HCC的诊断及治疗提供新视角。Abstract: Hepatocellular carcinoma （HCC） is the most common type of primary liver cancer and the third leading cause of cancer-related deaths， and it is a serious threat to human health and has become a clinical problem that needs to be solved urgently. Extracellular vesicles （EV） are membrane vesicles containing multiple components and play an important role in the development and progression of HCC. This article summarizes the effect of EVs of different origins on HCC and analyzes the mechanism of action of EV on HCC， so as to provide new perspectives for the diagnosis and treatment of HCC.
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Key words:
- Carcinoma， Hepatocellular /
- Extracellular Vesicles /
- Diagnosis
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图 2 M1/M2巨噬细胞极化及M2 TAM-EV对HCC的影响
Figure 2. M1/M2 macrophage polarization and impact of TAM-EV on HCC
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