小窝蛋白1在肝脏疾病中的调控作用

朱骏毅; 李瑞蕊; 舒仪雪; 孙泉

doi:10.12449/JCH240631

小窝蛋白1在肝脏疾病中的调控作用

DOI: 10.12449/JCH240631

首都医科大学基础医学院，北京 100069

基金项目:

北京市自然科学基金面上项目 (7222009)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：朱骏毅负责检索文献，撰写论文；李瑞蕊、舒仪雪参与修改论文；孙泉负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
孙泉， sunquan@ccmu.edu.cn （ORCID： 0000-0002-9367-3647）

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出版历程
- 收稿日期: 2023-10-30
- 录用日期: 2023-12-22
- 出版日期: 2024-06-25

Regulatory effect of caveolin-1 in liver diseases

School of Basic Medical Sciences，Capital Medical University，Beijing 100069，China

Research funding:

General Project of Natural Science Foundation of Beijing (7222009)

More Information

Corresponding author: SUN Quan， sunquan@ccmu.edu.cn （ORCID： 0000-0002-9367-3647）

摘要

摘要: 小窝蛋白（CAV）1是质膜上小窝的结构蛋白，是肝脏功能的重要调节因子。CAV1可通过多种分子通路调节肝脏脂质沉积、脂质和葡萄糖代谢、线粒体功能和肝细胞增殖等。因此，CAV1在肝脂肪变性和肝细胞增殖等代谢调节过程中维持肝脏生理方面起着至关重要的作用。此外，CAV1还参与调节不同类型肝损伤、肝炎、肝硬化等疾病的发生发展过程。本文就CAV1在肝脏及相关疾病中的作用及调控肝巨噬细胞的机制进行综述，为靶向CAV1治疗肝脏相关疾病提供理论依据。
- 小窝蛋白1 /
- 化学性与药物性肝损伤 /
- 肝纤维化 /
- 巨噬细胞
Abstract: Caveolin-1 （CAV1） is a structural protein of caveolae on the plasma membrane and is an important regulatory factor for liver function. CAV1 regulates hepatic lipid deposition， lipid and glucose metabolism， mitochondrial function， and hepatocyte proliferation through various molecular pathways. Therefore， CAV1 plays a crucial role in maintaining liver physiology during the metabolic regulatory processes such as hepatic steatosis and hepatocyte proliferation. Furthermore， CAV1 is also involved in the development and progression of different types of liver injury， hepatitis， and liver cirrhosis. This article reviews the role of CAV1 in liver-related diseases and its mechanism in the regulation of liver macrophages， so as to provide a theoretical basis for targeting CAV1 in the treatment of liver-related diseases.
- Caveolin-1 /
- Chemical and Drug Induced Liver Injury /
- Hepatic Fibrosis /
- Macrophages

HTML全文

图 1 CAV和CAV腔隙形成的模型示意图^［1］

注： a，CAV1和CAV2蛋白中不同氨基酸结构域及Cavin-1，-2，-3蛋白示意图。CAV1和Cavin-1，-2，-3负责小窝的形成、完整性、动力学、内化和信号传导。b，小窝的形成：CAV1被招募到质膜上，与脂质形成低聚物和簇。这吸引了Cavin接近细胞表面的CAV1阳性区域，形成初始膜曲率。CAV1和Cavin募集到质膜刺激其初始曲率，逐步发展到小窝完全形成。c，CAV1在肝细胞的分布：CAV1在肝细胞基底外侧质膜形成小窝，顶端质膜CAV1调节胆汁分泌到微管，以及位于再生肝细胞的脂滴表面。在其他胞内小室如高尔基体、内质网、早期和再循环内体、过氧化物酶体和线粒体也观察到了CAV1的分布。

Figure 1. Schematic diagram of the cavity formation model of Caveolins and Caveolins^［1］

下载: 全尺寸图片幻灯片

图 2 CAV1在炎症中的作用^［8］

Figure 2. The role of CAV1 in inflammation^［8］

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图 3 CAV1在肝脏缺血再灌注损伤过程中抑制过氧亚硝酸盐产生的关键作用示意图^［23］

Figure 3. Schematic diagram of the key role of CAV1 in inhibiting peroxynitrite production during hepatic ischemia-reperfusion injury^［23］

下载: 全尺寸图片幻灯片

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