脂代谢重编程与原发性肝癌发生发展的关系

李飞燕; 王明刚; 毛德文; 张日云; 王娜; 罗银冰; 刘晓萍; 林玉培

doi:10.12449/JCH240829

脂代谢重编程与原发性肝癌发生发展的关系

DOI: 10.12449/JCH240829

1.
广西中医药大学研究生院，南宁 530200
2a.
广西中医药大学第一附属医院科研部，南宁 530023
2b.
广西中医药大学第一附属医院肝病科，南宁 530023

基金项目:

国家自然科学基金 (82274434);

国家自然科学基金 (81960841);

国家自然科学基金 (82060848);

广西自然科学基金 (2020GXNSFBA297115);

广西自然科学基金 (2020GXNSFAA297070);

广西中医药大学博士启动基金 (2020BS026);

广西中医药大学第一附属医院博士启动基金 (2020BS003);

广西研究生教育创新计划项目 (YCSW2023378);

广西研究生教育创新计划项目 (YCBZ2023157);

广西研究生教育创新计划项目 (YCSW2023384);

广西中医药大学研究生教育创新计划项目 (YCSY2022024);

广西高校中青年教师科研基础能力提升项目 (2022KY0284);

广西高校中青年教师科研基础能力提升项目 (2023KY0324)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：王明刚负责研究思路的设计；罗银冰、林玉培、刘晓萍负责查阅相关文献；张日云、王娜负责资料归纳和分析；李飞燕负责撰写论文；毛德文负责指导修改论文及最后定稿。

详细信息

通信作者:
王明刚， wmgyx2012@163.com （ORCID： 0000-0002-2781-6777）

计量
- 文章访问数: 219
- HTML全文浏览量: 124
- PDF下载量: 30
- 被引次数: 0
出版历程
- 收稿日期: 2023-09-28
- 录用日期: 2023-11-08
- 出版日期: 2024-08-25

Association of lipid metabolism reprogramming with the development and progression of primary liver cancer

1.
Graduate School，Guangxi University of Chinese Medicine，Nanning 530200，China
2a.
Department of Scientific Research，The First Affiliated Hospital of Guangxi University of Chinese Medicine Nanning 530023，China
2b.
Department of Hepatology，The First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530023，China

Research funding:

National Natural Science Foundation of China (82274434);

National Natural Science Foundation of China (81960841);

National Natural Science Foundation of China (82060848);

Guangxi Natural Science Foundation (2020GXNSFBA297115);

Guangxi Natural Science Foundation (2020GXNSFAA297070);

Doctoral Start-up Fund of Guangxi University of Chinese Medicine (2020BS026);

The First Affiliated Hospital of Guangxi University of Chinese Medicine Doctoral Start-up Fund (2020BS003);

Innovation Project of Guangxi Graduate Education (YCSW2023378);

Innovation Project of Guangxi Graduate Education (YCBZ2023157);

Innovation Project of Guangxi Graduate Education (YCSW2023384);

Innovation Project of Guangxi Graduate Education of GXUCM (YCSY2022024);

Project on Enhancement of Basic Research Ability of Young and Middle-aged Teachers in Guangxi Universities and Colleges (2022KY0284);

Project on Enhancement of Basic Research Ability of Young and Middle-aged Teachers in Guangxi Universities and Colleges (2023KY0324)

More Information

Corresponding author: WANG Minggang， wmgyx2012@163.com （ORCID： 0000-0002-2781-6777）

摘要

摘要: 脂质代谢作为维持生命之本，是保持细胞存活的前提，脂质稳态能迅速对代谢变化做出协调反应。在癌症发生发展过程中，为了满足质膜合成和能量产生，癌细胞的脂质代谢会升高。脂质代谢异常对原发性肝癌的进展起着重要作用。本文综述二者之间的关联，以期寻找进一步防治原发性肝癌的靶点。
- 肝肿瘤 /
- 脂类代谢 /
- 代谢重编程
Abstract: Lipid metabolism， as the basis of life maintenance， is a prerequisite for cell survival， and lipid homeostasis can rapidly respond to metabolic changes in a coordinated manner. In cancers， there is an increase in lipid metabolism in cancer cells to meet the requirements for plasma membrane synthesis and energy production. Abnormal lipid metabolism plays an important role in the progression of primary liver cancer. This article reviews the association between abnormal lipid metabolism and primary liver cancer， in order to find targets for the prevention and treatment of primary liver cancer.
- Liver Neoplasms /
- Lipid Metabolism /
- Metabolic Reprogramming

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参考文献(40)

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