中药活性成分调控糖代谢抗胆管癌的分子机制

赵方言; 李姗; 王祥麒; 尹怡

doi:10.12449/JCH240832

中药活性成分调控糖代谢抗胆管癌的分子机制

DOI: 10.12449/JCH240832

赵方言^1a,
李姗^1b,
王祥麒^2, , ,,
尹怡²

1a.
河南中医药大学第三临床医学院，郑州 450046
1b.
河南中医药大学医学院，郑州 450046
2.
河南中医药大学第三附属医院肿瘤科，郑州 450046

基金项目:

河南省中医药科学研究专项课题 (2023ZY2110);

河南省高等学校青年骨干教师资助项目 (2021GGJS084)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：赵方言负责资料分析，论文撰写；尹怡检索文献，收集数据；李姗、王祥麒负责拟定写作思路，修改论文及最后定稿。

详细信息

通信作者:
王祥麒， wangxiangqi777@163.com （ORCID： 0009-0000-9120-1702）

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- 被引次数: 1
出版历程
- 收稿日期: 2024-01-10
- 录用日期: 2024-02-01
- 出版日期: 2024-08-25

Molecular mechanism of traditional Chinese medicine active components in regulating glucose metabolism against cholangiocarcinoma

Fangyan ZHAO^1a,
Shan LI^1b,
Xiangqi WANG^{2
, ,
,},
Yi YIN²

1a.
The Third Clinical Medical College，Henan University of Chinese Medicine，Zhengzhou 450046，China
1b.
School of Medicine，Henan University of Chinese Medicine，Zhengzhou 450046，China
2.
Department of Oncology，The Third Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450046，China

Research funding:

The Special Project for Scientific Research on Traditional Chinese Medicine in Henan Province (2023ZY2110);

The Training Program for Young Scholars in Universities of Henan Province (2021GGJS084)

More Information

Corresponding author: WANG Xiangqi， wangxiangqi777@163.com （ORCID： 0009-0000-9120-1702）

摘要

摘要: 胆管癌是一种高度异质性的肿瘤，其发病隐匿、病情凶险、恶性程度高、预后极差。葡萄糖是胆管癌增殖和转移的主要能量来源，胆管癌细胞在快速增殖过程中其糖代谢途径会被重新编辑，产生大量能量以满足自身需求。中医药在胆管癌治疗中具有独特优势，中药活性成分已被证明可以通过调控糖代谢抑制胆管癌的发生和发展。本文对胆管癌中的糖代谢特点和中药活性成分调控糖代谢抗胆管癌进行综述，为胆管癌的治疗提供新思路。
- 胆管肿瘤 /
- 碳水化合物代谢 /
- 中药 /
- 药理作用分子作用机制（中药）
Abstract: Cholangiocarcinoma is a highly heterogeneous tumor with an insidious onset， severe conditions， a high degree of malignancy， and an extremely poor prognosis. Glucose is a major energy source for the proliferation and metastasis of cholangiocarcinoma， and the glucose metabolism pathway of cholangiocarcinoma cells will be re-edited in the process of rapid proliferation to produce a large amount of energy for their own needs. Traditional Chinese medicine has unique advantages in the treatment of cholangiocarcinoma， and studies have shown that the active components of traditional Chinese medicine can inhibit the development and progression of cholangiocarcinoma by regulating glucose metabolism. This article reviews the characteristics of glucose metabolism in cholangiocarcinoma and the role of the active components of traditional Chinese medicine in regulating glucose metabolism against cholangiocarcinoma， in order to provide new ideas for the treatment of cholangiocarcinoma.
- Bile Duct Neoplasms /
- Carbohydrate Metabolism /
- Traditional Chinese Drugs /
- Molecular Mechanisms of Pharmacological Action （TCD）

HTML全文

【据Journal of Gastroenterology and Hepatology 2021年1月报道】题：自发性脾肾分流对肝硬化患者长期生存的影响(作者Yi F等)

自发性脾肾分流(SSRS)是肝硬化门静脉高压的表现之一。然而，SSRS对肝硬化患者长期生存的影响尚不清楚。来自北部战区总医院消化内科的Yi等推测SSRS可能通过减少肝血流灌注使肝功能恶化，并增加肝硬化死亡的风险。

研究筛选了于2014年12月—2019年8月连续住院且接受腹部增强CT/MRI检查的肝硬化患者。测量门静脉系血管和SSRS的最大直径，计算肝腹面积比(LAAR)。对所有患者进行随访，最后一次随访日期为2019年8月31日。研究共纳入122例肝硬化患者，其中30.3%发现有SSRS，SSRS患者门静脉右支、门静脉主干最大直径和LAAR评分中位数明显小于无SSRS患者(9 mm vs 11.20 mm、15.30 mm vs 16.80 mm、25.39 vs 31.58，P值分别为0.001、0.017、＜0.001)；SSRS患者Child-Pugh B/C级占比、MELD评分中位数、死亡率明显高于无SSRS患者(62.1% vs 43.5%、12.17 vs 9.79、18.9% vs 4.7%，P值分别为0.026、0.006、0.012)。Kaplan-Meier曲线分析发现，SSRS患者累积生存率明显低于无SSRS患者(P=0.014)。Cox回归分析显示，SSRS是肝硬化患者死亡率增加的危险因素(RR=4.161，95%CI: 1.215~14.255，P=0.023)。

研究表明，肝硬化SSRS患者的门静脉直径更细，肝功能更差，肝体积更小，死亡率更高。

摘译自YI F, GUO X, WANG L, et al. Impact of spontaneous splenorenal shunt on liver volume and long-term survival of liver cirrhosis[J]. J Gastroenterol Hepatol, 2021. [Online ahead of print]. DOI: 10.1111/jgh.15386.

(北部战区总医院消化内科易芳芳祁兴顺报道)

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