肝再生在对乙酰氨基酚诱导的肝损伤修复中的作用

莫胤康; 范子豪; 任锋

doi:10.12449/JCH240929

肝再生在对乙酰氨基酚诱导的肝损伤修复中的作用

DOI: 10.12449/JCH240929

首都医科大学附属北京佑安医院，北京肝病研究所，北京 100069

基金项目:

国家自然科学基金 (81770611);

国家自然科学基金 (82002243);

北京自然科学基金和北京市教委联合资助重点项目 (KZ202010025035);

首都卫生发展科研专项重点攻关项目 (SF2020-1-1151);

北京市科技计划“首都临床诊疗技术研究及示范应用”专项课题 (Z191100006619096);

北京市科技计划“首都临床诊疗技术研究及示范应用”专项课题 (Z191100006619097);

北京市医院管理中心“青苗”计划专项经费资助项目 (QML20201702);

北京市医管局“登峰”人才计划 (DFL20221503);

高层次公共卫生技术人才建设项目 (Subject leaders-02-13);

2023年度北京市自然科学基金-昌平创新联合基金拟资助项目 (L234046)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：莫胤康负责设计论文框架，起草论文；范子豪、莫胤康负责论文修改；任锋负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
任锋， renfeng7512@ccmu.edu.cn （ORCID： 0000-0001-7736-8637）

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出版历程
- 收稿日期: 2023-12-28
- 录用日期: 2024-04-22
- 出版日期: 2024-09-25

Role of liver regeneration in the repair of liver injury induced by N-acetyl-p-aminophenol

Beijing Institute of Hepatology，Beijing YouAn Hospital，Capital Medical University，Beijing 100069，China

Research funding:

National Natural Science Foundation of China (81770611);

National Natural Science Foundation of China (82002243);

Key Projects of the Beijing Municipal Education Commission’s Science and Technology Plan (KZ202010025035);

Special Key Research Project of Capital Health Development Scientific Research (SF2020-1-1151);

Capital Clinical Characteristic Diagnosis and Treatment Technology Research and Transformation Application (Z191100006619096);

Capital Clinical Characteristic Diagnosis and Treatment Technology Research and Transformation Application (Z191100006619097);

Beijing Hospitals Authority Youth Programme (QML20201702);

Talent Cultivation Plan of “Climbing the peak” of Beijing Municipal Hospital Administration (DFL20221503);

High-level Public Health Technical Personnel Construction Project (Subject leaders-02-13);

Proposed Funding Project for the 2023 Beijing Natural Science Foundation Changping Innovation Joint Fund (L234046)

More Information

Corresponding author: REN Feng， renfeng7512@ccmu.edu.cn （ORCID： 0000-0001-7736-8637）

摘要

摘要: 肝再生在对乙酰氨基酚（APAP）诱导的肝损伤后恢复中有着至关重要的作用。APAP过量服用后，通常是肝损伤程度越大，再生的程度就越大，从而导致肝损伤的消退和大多数情况下的自发恢复。然而，严重APAP过量会导致肝再生受损和无法控制的肝损伤，导致无法恢复，甚至死亡。在APAP肝损伤后，肝脏中细胞之间的相互作用对再生反应非常重要。肝再生由多种增殖信号通路共同调控，这些通路涉及激酶、核受体、转录因子、转录共激活因子。严重的APAP过量后会抑制增殖信号通路的激活，导致细胞周期停滞和肝再生受损。虽然肝再生在APAP肝损伤后的修复过程中发挥关键作用，但目前其发挥作用的潜在机制尚不明确。本文就已有的相关研究对肝再生在APAP诱导的肝损伤中的作用进行综述，为进一步的基础研究提供参考。
- 化学性与药物性肝损伤 /
- 对乙酰氨基酚 /
- 信号传导 /
- 修复
Abstract: Liver regeneration plays a crucial role in the recovery after liver injury induced by N-acetyl-p-aminophenol （APAP）. After APAP overdose， the degree of regeneration increases with the extent of liver injury， leading to the resolution of liver injury and spontaneous recovery in most cases. However， severe APAP overdose can impair liver regeneration and result in uncontrolled liver injury， even failure to recover or death in severe cases. Following APAP-induced liver injury， interactions between cells in the liver are essential for regenerative response. Liver regeneration is jointly regulated by multiple proliferative signaling pathways， involving various kinases， nuclear receptors， transcription factors， and coactivators. Severe APAP overdose can inhibit the activation of proliferative signaling pathways， thereby causing cell cycle arrest and impairing liver regeneration. Although liver regeneration plays a critical role in the repair of APAP-induced liver injury， the underlying mechanisms remain unclear. This article reviews the research advances in the role of liver regeneration in APAP-induced liver injury， in order to provide a reference for further basic research in this area.
- Chemical and Drug Induced Liver Injury /
- Acetaminophen /
- Signal Transduction /
- Repair

HTML全文

图 1 APAP诱导肝毒性后肝再生过程的机制图

Figure 1. Mechanism diagram of liver regeneration following APAP -hepatotoxicity

下载: 全尺寸图片幻灯片

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