巨噬细胞在原发性胆汁性胆管炎发生发展中的作用

邓宗柒; 邰文琳

doi:10.12449/JCH240932

巨噬细胞在原发性胆汁性胆管炎发生发展中的作用

DOI: 10.12449/JCH240932

邓宗柒,
邰文琳^, ,

昆明医科大学第二附属医院检验科，昆明 650101

基金项目:

国家自然科学基金 (82060385);

昆明医科大学2024年研究生创新基金 (2024S091)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：邓宗柒负责收集资料及文章撰写；邰文琳负责文章修改及定稿。

详细信息

通信作者:
邰文琳， taiwenlin2685@163.com （ORCID： 0000-0002-8278-929X）

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- 被引次数: 0
出版历程
- 收稿日期: 2024-01-09
- 录用日期: 2024-03-07
- 出版日期: 2024-09-25

Role of macrophages in the development and progression of primary biliary cholangitis

Zongqi DENG,
Wenlin TAI^{,
,}

Department of Clinical Laboratory，The Second Affiliated Hospital of Kunming Medical University，Kunming 650101，China

Research funding:

National Natural Science Foundation of China (82060385);

Innovation Fund for Graduate Students of Kunming Medical University in 2024 (2024S091)

More Information

Corresponding author: TAI Wenlin， taiwenlin2685@163.com （ORCID： 0000-0002-8278-929X）

摘要

摘要: 原发性胆汁性胆管炎（PBC）是一种持续的炎症性自身免疫性肝病，以肝内小胆管炎症损伤和胆汁淤积为主要特征。目前，PBC的确切发病机制尚不清楚，但一致认为PBC是多种因素协同作用的结果。而在与PBC相关的免疫和炎症级联反应中，巨噬细胞作为必不可少的免疫细胞出现，积极参与对胆管上皮细胞的损伤。本文介绍了巨噬细胞在PBC中的来源定位及异质性变化，综述了巨噬细胞在PBC发病机制中的潜在作用。
- 原发性胆汁性胆管炎 /
- 单核细胞 /
- 巨噬细胞 /
- 病理过程
Abstract: Primary biliary cholangitis （PBC） is a persistent inflammatory autoimmune liver disease characterized by inflammatory injury and cholestasis in the small intrahepatic bile ducts. At present， the exact pathogenesis of PBC remains unknown， but a consensus has been reached on the fact that PBC is the result of the synergistic effect of various factors. In the cascade of immune and inflammatory reactions associated with PBC， macrophages appear as essential immune cells and actively participate in the damage to bile duct epithelial cells. This article introduces the origin and heterogeneity of macrophages in PBC and reviews the potential role of macrophages in the pathogenesis of PBC.
- Primary Biliary Cholangitis /
- Monocyte /
- Macrophage /
- Pathologic Processes

HTML全文

图 1 巨噬细胞参与PBC发病和进展的机制图

Figure 1. Mechanism diagram of macrophage involvement in the pathogenesis and progression of PBC

下载: 全尺寸图片幻灯片

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