胆道结石与胆源性胰腺炎的关系

李玮佳; 李振方; 张倩; 李聪; 王凤娇; 赵琦

doi:10.12449/JCH241031

胆道结石与胆源性胰腺炎的关系

DOI: 10.12449/JCH241031

李玮佳¹,
李振方²,
张倩²,
李聪³,
王凤娇²,
赵琦^2, , ,

1.
山东大学齐鲁医学院，济南 250012
2.
山东第一医科大学附属中心医院消化内科，济南 250013
3.
山东健康集团莱芜中心医院消化内科，济南 271100

基金项目:

济南市临床医学科技创新计划项目 (202328034)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：李玮佳、李振方、赵琦负责课题设计，资料分析，撰写论文；张倩、李聪、王凤娇参与收集数据，修改论文；赵琦负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
赵琦， klyjr@sina.com （ORCID： 0009-0000-0660-126X）

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出版历程
- 收稿日期: 2023-12-11
- 录用日期: 2024-05-28
- 出版日期: 2024-10-25

The association between gallstone and biliary pancreatitis

1.
Cheeloo College of Medicine，Shandong University，Jinan 250012，China
2.
Department of Gastroenterology，Central Hospital Affiliated to Shandong First Medical University，Jinan 250013，China
3.
Department of Gastroenterology，Laiwu Central Hospital of Shandong Health Group，Jinan 271100，China

Research funding:

Clinical Medical Development Program of Jinan Science and Technology Bureau (202328034)

More Information

Corresponding author: ZHAO Qi， klyjr@sina.com （ORCID： 0009-0000-0660-126X）

摘要

摘要: 急性胰腺炎是临床上最常见的急腹症之一，胆道疾病、酒精、胰管疾病、代谢障碍如高甘油三酯血症和高钙血症、过度进食、十二指肠降段疾病如十二指肠乳头旁憩室等是急性胰腺炎的常见病因。根据病因将急性胰腺炎分为胆源性胰腺炎、高脂血症性胰腺炎等。胆源性胰腺炎的致病因素很多，在全球范围内，胆道结石等胆系疾病仍是胆源性胰腺炎最主要的病因。各种病因导致的胆胰管排流不畅及压力异常、胆汁向胰管反流、胰液引流受阻、胰酶异常活化是导致胆源性胰腺炎发生的中心环节。胆道结石所在部位、结石大小、质地、数目、形状等与胆源性胰腺炎的发病率及严重程度一定的关系。
- 胰腺炎 /
- 急腹症 /
- 胆石
Abstract: Acute pancreatitis is one of the most common acute abdominal diseases in clinical practice， and the common etiologies of acute pancreatitis include biliary diseases， alcohol， pancreatic duct diseases， metabolic disorders （hypertriglyceridemia and hypercalcemia）， excessive eating， and diseases of the descending duodenum （periampullary duodenal diverticula）. According to the etiology， acute pancreatitis is classified into biliary pancreatitis and hyperlipidemic pancreatitis， and although there are various pathogenic factors for biliary pancreatitis， biliary diseases including bile duct stones remain the most important etiology of biliary pancreatitis. Obstructed biliopancreatic duct drainage and abnormal pressure due to various causes， bile reflux into the pancreatic duct， obstruction of pancreatic juice drainage， and abnormal activation of pancreatic enzymes are the central links in the development of biliary pancreatitis. The location， size， texture， number and shape of bile duct stones are associated with the incidence rate and severity of biliary pancreatitis to a certain degree.
- Pancreatitis /
- Abdomen， Acute /
- Gallstones

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图 1 胆源性胰腺炎发病机制

Figure 1. Pathogenesis of biliary pancreatitis

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