获得性免疫缺陷综合征（AIDS）患者合并肝损伤的危险因素及机制

孙可欣; 李强

doi:10.12449/JCH250732

获得性免疫缺陷综合征（AIDS）患者合并肝损伤的危险因素及机制

DOI: 10.12449/JCH250732

孙可欣,
李强^, ,

山东大学附属公共卫生临床中心，济南 250100

基金项目:

山东省重点研发计划 (2021SFGC0504)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：孙可欣负责阅读文献，收集数据，资料分析，撰写论文；李强负责确定选题，拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
李强， doctorliqiang@aliyun.com （ORCID： 0000-0002-8667-4676）

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出版历程
- 收稿日期: 2024-10-07
- 录用日期: 2024-12-27
- 出版日期: 2025-07-25

Risk factors and mechanisms of liver injury in patients with acquired immunodeficiency syndrome

Kexin SUN,
Qiang LI^{,
,}

Shandong Public Health Clinical Center Affiliated to Shandong University，Jinan 250100，China

Research funding:

Key R & D Plan of Shandong Province (2021SFGC0504)

More Information

Corresponding author: LI Qiang， doctorliqiang@aliyun.com （ORCID： 0000-0002-8667-4676）

摘要

摘要: 随着抗逆转录病毒治疗（ART）时代的到来，人类免疫缺陷病毒（HIV）感染者的寿命显著延长，非获得性免疫缺陷综合征（AIDS）相关疾病的发生率较ART应用前明显升高，其中肝脏疾病是非AIDS相关死亡的主要原因之一。HIV感染者肝损伤发生率较高，造成肝损伤的原因有多方面。本文从HIV感染、合并HBV/HCV及其他病原体感染、药物、代谢功能障碍、肠道菌群移位等多个方面对发生肝损伤可能的危险因素及机制进行综述，为HIV感染者的管理提供参考。
- HIV /
- 获得性免疫缺陷综合征 /
- 化学性与药物性肝损伤 /
- 肝炎病毒 /
- 非酒精性脂肪性肝病
Abstract: With the advent of the era of antiretroviral therapy， the lifespan of individuals living with human immunodeficiency virus （HIV） infection has been extended significantly， and there is a significant increase in the incidence rate of non-acquired immunodeficiency syndrome （AIDS）-related diseases， among which liver disease is one of the main causes of non-AIDS-related deaths. There is still a relatively high incidence rate of liver injury in patients with HIV infection， and there are various causes of liver injury. This article reviews the possible risk factors for liver injury and related mechanisms from the aspects of HIV infection， co-infection with hepatitis B virus/hepatitis C virus and other pathogens， drugs， metabolic dysfunction， and intestinal bacterial translocation， in order to provide a reference for the management of individuals with HIV infection.
- HIV /
- Acquired Immunodeficiency Syndrome /
- Chemical and Drug Induced Liver Injury /
- Hepatitis Viruses /
- Non-alcoholic Fatty Liver Disease

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参考文献(59)

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