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cGAS-STING通路在肝脏疾病中的作用机制与治疗靶点研究进展
DOI: 10.12449/JCH251033
利益冲突声明：本文不存在任何利益冲突。
作者贡献声明：翟玉洁负责撰写论文；李向向负责修改论文；吴楚江、张亚南、贺昱昕、刘仲禹负责归纳文献；张久聪、梁斌负责拟定写作思路，指导撰写文章并最后定稿。
Mechanism of action of the cyclic GMP-AMP synthase-stimulator of interferon genes signaling pathway in liver diseases and research advances in therapeutic targets
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摘要: 肝脏疾病是一类由多种原因引发的复杂临床疾病，可导致肝细胞损伤及肝功能障碍，严重威胁人类健康。cGAS-STING信号通路在肝脏疾病的病程中发挥关键调控作用，参与病毒性肝炎、非酒精性脂肪性肝病、肝纤维化和肝癌等疾病的发生、发展与治疗。本文综述了cGAS-STING信号通路在炎症、自噬、抗病毒及氧化应激等过程中的调控机制，深入解析其在肝脏疾病中的分子作用，并探讨了其作为治疗肝脏疾病潜在靶点的应用前景，旨在为开发肝脏疾病的新型治疗策略提供理论依据。
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关键词:
- 肝疾病 /
- cGAS-STING信号通路 /
- 病理过程 /
- 治疗学
Abstract: Liver diseases are a group of complex clinical conditions caused by various factors and can lead to hepatocyte damage and liver dysfunction， posing a serious threat to human health. The cyclic GMP-AMP synthase （cGAS）-stimulator of interferon genes （STING） signaling pathway plays a key regulatory role in the course of liver diseases and is involved in the development， progression， and treatment of various diseases such as viral hepatitis， nonalcoholic fatty liver disease， liver fibrosis， and liver cancer. This article reviews the regulatory mechanisms of the cGAS-STING signaling pathway in processes such as inflammation， autophagy， antiviral response， and oxidative stress， analyzes its molecular function in liver diseases， and explores its application prospect as a potential target for the treatment of liver diseases， in order to provide a theoretical basis for developing novel therapeutic strategies for liver diseases.-
Key words:
- Liver Diseases /
- cGAS-STING Signaling Pathway /
- Pathologic Processes /
- Therapeutics
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