雌激素缺乏通过肠道屏障影响自身免疫性肝炎的作用机制

宋明珠; 李玲; 朱金霞; 张数; 刘光伟

doi:10.12449/JCH260226

雌激素缺乏通过肠道屏障影响自身免疫性肝炎的作用机制

DOI: 10.12449/JCH260226

宋明珠¹,
李玲¹,
朱金霞²,
张数^{2, 3},
刘光伟^2, , ,

1.
河南中医药大学第一附属医院脾胃肝胆科三病区，郑州 450000
2.
上海中医药大学附属龙华医院肝病科，上海 200032
3.
河南中医药大学第一附属医院脑病中心，郑州 450000

基金项目:

河南省自然科学基金 (222300420490);

河南省科技研发计划联合基金 (222301420069);

2023年度河南省中医学“双一流”创建科学研究专项课题 (HSRP-DFCTCM-2023-7-24);

2023年度河南省卫生健康委国家中医药传承创新中心科研专项 (2023ZXZX1129)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：宋明珠负责构建写作思路、文献资料的整理与分析及撰写全文；李玲、张数与朱金霞则负责优化文章内容及结构；刘光伟对文章的撰写和修改过程进行指导。

详细信息

通信作者:
刘光伟， liuguangwei1975@163.com （ORCID： 0000-0002-6641-1625）

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出版历程
- 收稿日期: 2025-06-28
- 录用日期: 2025-09-29
- 出版日期: 2026-02-25

Mechanism of action of estrogen deficiency in autoimmune hepatitis via the intestinal barrier

Mingzhu SONG¹,
Ling LI¹,
Jinxia ZHU²,
Shu ZHANG^{2, 3},
Guangwei LIU^{2
, ,
,}

1.
Third Ward of Spleen，Stomach and Hepatobiliary Department，The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China
2.
Department of Liver Diseases，Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai 200032，China
3.
Encephalopathy Center，The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

Research funding:

Natural Science Foundation of Henan Province (222300420490);

Joint Fund Project of Henan Provincial R&D Program (222301420069);

Henan TCM Double First-Class Research Grant in 2023 (HSRP-DFCTCM-2023-7-24);

Henan Health Commission TCM Innovation Center Grant in 2023 (2023ZXZX1129)

More Information

Corresponding author: LIU Guangwei， liuguangwei1975@163.com （ORCID： 0000-0002-6641-1625）

摘要

摘要: 自身免疫性肝炎（AIH）是一种由免疫介导的慢性肝脏炎性疾病，其发病机制尚未完全阐明，肠道屏障功能障碍被认为是潜在的重要环节。同时，AIH的发病率与严重程度存在性别及年龄差异，提示激素可能参与调控。基于此，本文围绕雌激素、肠道屏障与免疫稳态的关联，系统综述了雌激素缺乏破坏肠道屏障稳态的证据，并进一步归纳了雌激素通过肠道屏障调控AIH发生发展的潜在机制。此外，本文提出雌激素干预的“时间窗”理论可能同样适用于AIH，为AIH的早期预防与个体化治疗提供了新思路。
- 雌激素类 /
- 肠道屏障功能 /
- 肝炎，自身免疫性
Abstract: Autoimmune hepatitis （AIH） is an immune-mediated chronic liver inflammatory disease with unknown pathogenesis， and intestinal barrier dysfunction is considered an important factor. Meanwhile， there are sex and age differences in the incidence rate of AIH， suggesting that hormone may be involved in regulation. On this basis， this article focuses on the association between estrogen， intestinal barrier， and immune homeostasis， systematically reviews the evidence that estrogen deficiency disrupts intestinal barrier homeostasis， and further summarizes the potential mechanism of estrogen in regulating the development and progression of AIH via intestinal barrier.
- Estrogens /
- Intestinal Barrier Function /
- Hepatitis， Autoimmune

HTML全文

注： AJ，黏附连接；AMP，抗菌肽；cAMP-PKA，环磷酸腺苷-蛋白激酶A信号通路；DC，树突状细胞；GPBAR1受体，G蛋白偶联胆汁酸受体1；IEC，肠上皮细胞；KC，肝巨噬细胞；LPS，脂多糖；MUC，黏蛋白；PAMP，病原体相关分子模式；ROS，活性氧；SlgA，分泌型免疫球蛋白A；SCFA，短链脂肪酸；SBA，次级胆汁酸；SOD，超氧化物歧化酶；TJ，紧密连接；Treg，调节性T细胞；Th17，辅助性T细胞17；TLR4，Toll样受体4；TNF-α，肿瘤坏死因子-α；IL，白细胞介素；AIH，自身免疫性肝炎；FoxP3，叉头框蛋白P3；TGF-β，转化生长因子-β；IFN-γ，γ干扰素。

图 1 雌激素缺乏调控肠道屏障影响AIH的作用机制图

Figure 1. TMechanism Underlying Estrogen Deficiency-Induced AIH via Gut Barrier Dysfunction

下载: 全尺寸图片幻灯片

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