肝豆状核变性的中医证候学与辨证治疗

郝文杰; 杨文明; 程婷; 江海林; 汪瀚; 汪美霞

doi:10.12449/JCH260305

肝豆状核变性的中医证候学与辨证治疗

DOI: 10.12449/JCH260305

郝文杰^{1, 2},
杨文明^{1, 2, 3, 4, , ,},
程婷^{1, 2},
江海林^{1, 2},
汪瀚^{1, 2},
汪美霞^{1, 2}

1.
安徽中医药大学第一附属医院脑病中心，合肥 230031
2.
安徽中医药大学脑病研究院，合肥 230031
3.
合肥综合性国家科学中心大健康研究院新安医学与中医药现代化研究所，合肥 230071
4.
新安医学教育部重点实验室，合肥 230038

基金项目:

国家自然科学基金 (U22A20366);

国家自然科学基金 (82505546);

安徽省自然科学基金 (2408085QH283);

安徽省高等学校科研项目 (2024AH051003);

安徽省中医药科技攻关专项 (202303a07020004);

安徽中医药大学临床科研项目 (2024YFYLCZX17);

安徽省教育厅科学研究项目 (2025AHGXZK40547);

安徽省临床医学研究转化专项 (202204295107020066)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：郝文杰负责设计论文框架，起草论文；程婷、江海林、汪瀚、汪美霞负责论文修改；杨文明负责指导撰写文章并最后定稿。

详细信息

通信作者:
杨文明， yangwm8810@126.com （ORCID： 0000-0001-8268-9291）

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- 被引次数: 0
出版历程
- 收稿日期: 2026-01-15
- 录用日期: 2026-02-10
- 出版日期: 2026-03-25

Traditional Chinese medicine syndrome and syndrome differentiation-based treatment of Wilson disease

Wenjie HAO^{1, 2},
Wenming YANG^{1, 2, 3, 4
, ,
,},
Ting CHENG^{1, 2},
Hailin JIANG^{1, 2},
Han WANG^{1, 2},
Meixia WANG^{1, 2}

1.
Encephalopathy Center，The First Affiliated Hospital of Anhui University of Chinese Medicine，Hefei 230031，China
2.
Research Institute of Brain Diseases，Anhui University of Chinese Medicine，Hefei 230031，China
3.
Center for Xin’an Medicine and Modernization of Traditional Chinese Medicine，Institute of Health and Medicine，Hefei Comprehensive National Science Center，Hefei 230071，China
4.
Key Laboratory of Xin’an Medicine，Ministry of Education，Hefei 230038，China

Research funding:

National Natural Science Foundation of China (U22A20366);

National Natural Science Foundation of China (82505546);

Anhui Natural Science Foundation (2408085QH283);

Anhui Higher Education Institutions Scientific Research Project (2024AH051003);

Anhui Provincial Special Project for Scientific and Technological Innovation in Traditional Chinese Medicine (202303a07020004);

Clinical Research Project of Anhui University of Chinese Medicine (2024YFYLCZX17);

Scientific Research Project of the Education Department of Anhui Province (2025AHGXZK40547);

Special Project for Clinical Medical Research Transformation of Anhui Province (202204295107020066)

More Information

Corresponding author: YANG Wenming， yangwm8810@126.com （ORCID： 0000-0001-8268-9291）

摘要

摘要: 肝豆状核变性是一种常染色体隐性遗传的铜代谢障碍疾病，西医主要采用驱铜及对症治疗。本文系统梳理了肝豆状核变性的中医病因病机认识，认为其核心在于先天禀赋异常，铜毒内蕴为标，肝、脾和肾功能失调为本，病机关键为“毒、瘀、痰、虚”交织互结。通过文献研究与临床观察，总结出肝豆状核变性常见的中医证型，包括肝气郁结证、湿热内蕴证、痰瘀热结证、肝肾阴亏证、脾肾阳虚证及虚损痰瘀证。针对各证型提出相应的治法与代表方药，并探讨了分期论治与中西医结合治疗的优势。本文旨在为肝豆状核变性的中医临床辨证施治提供系统参考，以更好地发挥中医药在该病治疗中的优势。
- 肝豆状核变性 /
- 证候 /
- 辨证论治 /
- 中医治疗学
Abstract: Wilson disease （WD） is an autosomal recessive disorder of copper metabolism， and decoppering therapy and symptomatic treatment are the main Western medicine therapies for WD. This article systematically reviews the understanding of the etiology and pathogenesis of WD in traditional Chinese medicine （TCM） and points out that abnormal natural endowment is the core etiology and pathogenesis of WD， with internal accumulation of copper toxicity as the manifestation， liver/spleen/kidney dysfunction as the root cause， and intermingled “toxin， stasis， phlegm， and deficiency” as the key pathogenesis. Literature research and clinical observation are conducted to summarize the common TCM syndromes of WD， including stagnation of liver Qi， internal retention of damp-heat， phlegm-stasis-heat accumulation syndrome， liver-kidney Yin deficiency syndrome， spleen-kidney Yang deficiency， and syndrome of deficiency damage and phlegm stasis. This article proposes the corresponding therapies and representative prescriptions for each syndrome and discusses the advantages of treatment by stage and integrated traditional Chinese and Western medicine therapy. This article aims to provide a systematic reference for the syndrome differentiation-based treatment of WD in clinical practice of TCM， thereby giving full play to the advantages of TCM in the treatment of this disease.
- Hepatolenticular Degeneration /
- Symptom Complex /
- Treatment Based on Syndrome Differentiation /
- Therapeutics （TCM）

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参考文献(35)

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