原发性胆汁性胆管炎患者疲劳的发生机制及临床评估与干预

任威瑞; 张创; 赵文娟; 王军民

doi:10.12449/JCH260326

原发性胆汁性胆管炎患者疲劳的发生机制及临床评估与干预

DOI: 10.12449/JCH260326

任威瑞¹,
张创²,
赵文娟¹,
王军民^1, , ,

1.
河北医科大学第三医院消化内科，石家庄 050000
2.
石家庄医学高等专科学校临床医学系，石家庄 050000

基金项目:

河北省财政厅优秀人才基金 (ZF2024073);

河北医科大学第三医院2025年度院内中医药、中西医结合课题基金 (ydsyzyy202505)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：任威瑞负责拟定写作思路，撰写论文；张创、赵文娟负责文献检索，整理内容；王军民负责指导撰写文章并最后定稿。

详细信息

通信作者:
王军民， teacher2021@hebmu.edu.cn（ORCID： 0000-0002-9007-9263）

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- 被引次数: 0
出版历程
- 收稿日期: 2025-07-15
- 录用日期: 2025-09-23
- 出版日期: 2026-03-25

Pathogenesis， clinical assessment， and intervention of fatigue in patients with primary biliary cholangitis

1.
Department of Gastroenterology，Third Hospital of Hebei Medical University，Shijiazhuang 050000，China
2.
College of Clinical Medicine，Shijiazhuang Medical College，Shijiazhuang 050000，China

Research funding:

Excellent Talents Fund of Hebei Provincial Department of Finance (ZF2024073);

The 2025 Annual In-hospital Research Project on Traditional Chinese Medicine and Integrated Traditional Chinese and Western Medicine of Hebei Medical University Third Hospital (ydsyzyy202505)

More Information

Corresponding author: WANG Junmin， teacher2021@hebmu.edu.cn （ORCID： 0000-0002-9007-9263）

摘要

摘要: 原发性胆汁性胆管炎（PBC）是一种以肝内胆汁淤积为特征的自身免疫性肝病，疲劳是其常见且显著影响生活质量的重要症状。PBC患者疲劳的发生机制复杂，可能与胆汁淤积引发的炎症反应、肠道菌群紊乱、脑结构和功能异常以及线粒体功能障碍等因素有关。当前，一线药物和肝移植对改善疲劳的效果有限，且缺乏统一的综合评估体系。新兴药物和生活方式调整等非药物干预手段，则表现出潜在的应用前景。本文系统综述了PBC患者疲劳的临床表现、发生机制、临床评估及干预措施的研究进展，旨在为优化治疗策略和推动新疗法研发提供参考。
- 原发性胆汁性胆管炎 /
- 疲劳 /
- 治疗学
Abstract: Primary biliary cholangitis （PBC） is an autoimmune liver disease characterized by intrahepatic cholestasis， while fatigue is a common symptom of PBC that significantly affects the quality of life of patients. The pathogenesis of fatigue is complex and may be associated with the factors such as cholestasis-induced inflammation， gut microbiota dysbiosis， brain structural and functional abnormalities， and mitochondrial dysfunction. At present， first-line therapies and liver transplantation have a limited effect in alleviating fatigue， and there is still a lack of standardized comprehensive assessment system. Emerging drugs and non-pharmaceutical interventions， including lifestyle modifications， have shown potential application prospects. This article systematically reviews the research advances in the clinical manifestations， pathogenesis， clinical assessment， and intervention of fatigue in PBC patients， in order to provide a reference for optimizing treatment strategies and promoting the research and development of new therapies.
- Primary Biliary Cholangitis /
- Fatigue /
- Therapeutics

HTML全文

注： PBC-40，原发性胆汁性肝硬化生活质量量表；FIS，疲劳影响量表；PROMIS，患者报告结局测量信息系统简表；AMA，抗线粒体抗体；UDCA，熊去氧胆酸；OCA，奥贝胆酸。

图 1 原发性胆汁性胆管炎患者疲劳的发生机制及临床评估与干预

Figure 1. The pathogenesis， clinical assessment and intervention of fatigue in PBC

下载: 全尺寸图片幻灯片

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