甘肃地区汉族HCV基因分型相关分析

彭雪彬; 毛小荣; 陈红

doi:10.3969/j.issn.1001-5256.2013.11.007

甘肃地区汉族HCV基因分型相关分析

DOI: 10.3969/j.issn.1001-5256.2013.11.007

兰州大学第一医院感染科

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中图分类号: R512.63
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出版历程
- 收稿日期: 2013-02-20
- 出版日期: 2013-11-20

Genotypes of HCV in hepatitis C patients of Han nationality in Gansu, China

Department of Infectious Diseases, The First Hospital of Lanzhou University

摘要

摘要: 目的调查甘肃地区汉族丙型肝炎病毒（HCV）基因分型分布情况及与其可能的传播途径、其他相关临床指标之间的关系。方法收集甘肃地区汉族220例患者完整数据,包括性别、年龄、可能的感染途径、病毒水平及生化检查。计量资料采用t检验以及秩和检验分析,计数资料采用卡方检验,采用多因素Logistic回归分析研究HCV基因型与临床的相关性。结果 220例患者共检出1b型84例（38%）,2a型136例（62%）。对220例不同HCV基因型感染者的年龄、性别、感染途径、HCV RNA、ALT、AST、TBil、IBil、DBil、ALP、GGT等11项观察指标进行单因素分析结果表明,感染途径、HCV RNA及ALT与HCV基因型间存在相关性（χ2=23.947,P<0.001;Z=-3.349,P=0.001;t=-2.325,P=0.021）,而年龄、性别、AST、TBil、IBil、DBil、ALP、GGT等指标均与HCV基因型无关（P>0.05）。再经多因素Logistic回归分析显示,该3项均与HCV基因型有关（χ2=3.993,P=0.046;χ2=9.308,P=0.002;χ2...
- 肝炎病毒属 /
- 甘肃 /
- 基因型
Abstract: Objective To investigate the genotypes of hepatitis C virus ( HCV) among the hepatitis C patients of Han nationality in Gansu, China, as well as their possible routes of transmission and relationship with clinical indices. Methods The complete data regarding hepatitis C, including sex, age, possible routes of transmission, HCV RNA level, and biochemical parameters, were collected from 220 hepatitis C patients of Han nationality in Gansu. Continuous data were analyzed by t test and rank sum test; categorical data were analyzed by chi-square test; multivariate logistic regression analysis was used to investigate the relationship between HCV genotypes and clinical indices. Results HCV genotype 1b was detected in 84 ( 38%) of all patients, and genotype 2a in 136 ( 62%) of these patients. The univariate analysis of 11 factors including age, sex, route of transmission, HCV RNA, alanine aminotransferase ( ALT) , aspartate aminotransferase ( AST) , total bilirubin ( TBil) , indirect bilirubin ( IBil) , direct bilirubin ( DBil) , alanine phosphatase ( ALP) , and gamma- glutamyl transpeptidase ( GGT) showed that the route of transmission, ALT, and HCV RNA were correlated with HCV genotypes ( χ2= 23. 947, P < 0. 001; Z=- 3. 349, P = 0. 001; t =- 2. 325, P = 0. 021) , but age, sex, AST, TBil, IBbil, DBil, ALP, and GGT were not correlated with HCV genotypes ( P > 0. 05) . The multivariate logistic regression analysis showed that the above three factors were correlated with HCV genotypes ( χ2= 3. 993, P = 0. 046; χ2= 9. 308, P = 0. 002; χ2= 11. 652, P = 0. 001) . The number of genotype 2a patients was larger than that of genotype 1b patients among patients with high HCV RNA levels ( ≥106 IU / ml) and those with high ALT levels ( > 49 U / L) . HCV genotype 1b was more likely to be transmitted by blood transfusion and oral treatment compared with other routes. Conclusion Genotype 1b and genotype 2a are the main genotypes of HCV among the hepatitis C patients of Han nationality in Gansu, and genotype 2a is more common.Genotype 2a patients are more prone to high HCV RNA level and liver damage. In Gansu, HCV is transmitted mainly by blood transfusion, followed by oral treatment, and genotype 1b is more likely than genotype 2a to be transmitted by the two routes.
- hepacivirus /
- Gansu /
- genotypes

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