中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

两种途径移植自体骨髓干细胞治疗肝硬化患者的疗效比较

王方 寇俊峰 云升皓 蔡国芳 王可敬 杨兴坤

王方, 寇俊峰, 云升皓, 蔡国芳, 王可敬, 杨兴坤. 两种途径移植自体骨髓干细胞治疗肝硬化患者的疗效比较[J]. 临床肝胆病杂志, 2013, 29(11): 844-847. DOI: 10.3969/j.issn.1001-5256.2013.11.011.
引用本文: 王方, 寇俊峰, 云升皓, 蔡国芳, 王可敬, 杨兴坤. 两种途径移植自体骨髓干细胞治疗肝硬化患者的疗效比较[J]. 临床肝胆病杂志, 2013, 29(11): 844-847. DOI: 10.3969/j.issn.1001-5256.2013.11.011.
Wang Fang, Kou JunFeng, Yun ShengHao, Cai GuoFang, Wang KeJing, Yang XingKun. Therapeutic effect of autologous bone marrow stem cell transplantation through portal vein or hepatic artery in treatment of decompensated liver cirrhosis: a comparative study[J]. J Clin Hepatol, 2013, 29(11): 844-847. DOI: 10.3969/j.issn.1001-5256.2013.11.011.
Citation: Wang Fang, Kou JunFeng, Yun ShengHao, Cai GuoFang, Wang KeJing, Yang XingKun. Therapeutic effect of autologous bone marrow stem cell transplantation through portal vein or hepatic artery in treatment of decompensated liver cirrhosis: a comparative study[J]. J Clin Hepatol, 2013, 29(11): 844-847. DOI: 10.3969/j.issn.1001-5256.2013.11.011.

两种途径移植自体骨髓干细胞治疗肝硬化患者的疗效比较

DOI: 10.3969/j.issn.1001-5256.2013.11.011
详细信息
  • 中图分类号: R575.2

Therapeutic effect of autologous bone marrow stem cell transplantation through portal vein or hepatic artery in treatment of decompensated liver cirrhosis: a comparative study

  • 摘要: 目的比较经肝动脉和门静脉移植自体骨髓干细胞治疗失代偿期肝硬化患者的疗效和安全性。方法回顾性分析2006年12月至2012年5月50例住院患者资料,门静脉治疗组失代偿期肝硬化患者25例和肝动脉治疗组25例,两组基线特征差异无统计学意义。门静脉治疗组在基础治疗基础上在超声介入下经皮经肝穿刺至门静脉,注入自体骨髓干细胞治疗;肝动脉治疗组在基础治疗基础上在放射介入下经股动脉插管至肝固有动脉注入自体骨髓干细胞治疗。治疗后第2、4、8周检测两组患者ALT、AST、TBil、凝血酶原活动度(PTA)和白蛋白(Alb)水平变化。同时观察临床症状的改善情况及术后的不良反应。组间比较采用成组t检验,治疗前后比较采用配对t检验,计数资料采用卡方检验。结果门静脉组有22例(88.0%)患者乏力、纳差症状有明显改善,肝动脉组有21例(84.0%),两组间比较差异无统计学意义(P>0.05);治疗后8周,门静脉和肝动脉组患者血清Alb水平分别为(34.4±7.8)g/L和(33.8±8.0)g/L,较治疗前[分别为(27.1±8.9)g/L和(26.8±9.6)g/L]有显著提升(P均<0.05),但...

     

  • [1]XU Y, XUE BY.Study on integrated traditional Chinese and Western medicine therapy in treatment of hepatitis B cirrhosis[J].Jilin J Tradit Chin Med, 2011, 31 (12) :1180-1181. (in Chinese) 许岩, 薛博瑜.中西医治疗乙型肝炎肝硬化研究[J].吉林中医药, 2011, 31 (12) :1180-1181.[2]TERAI S, SAKAIDA I, YAMAMOTO N, et al.An uncomfortable silenceem leader while we all search for a better reporter gene in adult stem cell biology[J].Hepatology, 2004, 39 (4) :1143-1146.[3]LAGASSE E, CONNORS H, ALDHALIMY M, et al.Purified hematopoietic stem cells can differentiate into hepatocytes in vivo[J].Nat Med, 2000, 6 (11) :1229-1233.[4]YAO P, HU DR, WANG S, et al.Treatment of chronic hepatic failure with autologous bone marrow stem cells transplantation[J].Chin Hepatol, 2005, 10 (3) :171-173. (in Chinese) 姚鹏, 胡大荣, 王帅, 等.自体骨髓干细胞移植治疗慢性肝衰竭研究[J].肝脏, 2005, 10 (3) :171-173.[5]PAI M, ZACHAROULIS D, MILICEVIC MN, et al.Autologous infusion of expanded mobilized adult bone marrow-derived CD34+cells into patients with alcoholic liver cirrhosis[J].Am J Gastroenterol, 2008, 103 (8) :1952-1958.[6]LEVICAR N, PAI M, HABIB NA, et al.Long-term clinical results of autologous infusion of mobilized adult bone marrow derived CD34+cells in patients with chronic liver disease[J].Cell Prolif, 2008, 41 (1) :115-125.[7]TERAI S, ISHIKAWA T, OMORI K, et al.Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy[J].Stem Cells, 2006, 24 (10) :2292-2298.[8]MOHAMADNEJAD M, ALIMOGHADDAM K, MOHYEDDINBONAB M, et al.Phase 1 trial of autologous bone marrow mesenchymal stem cell transplantation in patients with decompensated liver cirrhosis[J].Arch Iran Med, 2007, 10 (4) :459-466.[9]KHAN AA, PARVEEN N, MAHABOOB VS, et al.Safety and efficacy of autologous bone marrow stem cell transplantation through hepatic artery for the treatment of chronic liver failure:a preliminary study[J].Transplant Proc, 2008, 40 (4) :1140-1144.[10]WANG F, ZHANG J, ZHOU XR, et al.The curative effect of automarrow stem cells transplantation through portal vein in treatment of 18patients with decompensated liver cirrhosis[J].J Clin Hepatol, 2011, 14 (3) :200-201. (in Chinese) 王方, 张静, 周新人, 等.经门静脉自体骨髓干细胞移植治疗失代偿期肝硬化18例疗效观察[J].实用肝脏病杂志, 2011, 14 (3) :200-201.[11]WANG F, ZHANG ZG, ZHANG J, et al.The curative effect of auto-marrow stem cells in treatment fo 50 patients with decompensated liver cirrhosis[J].J Clin Hepatol, 2010, 13 (4) :272-274. (in Chinese) 王方, 张小岗, 张静, 等.自体骨髓干细胞治疗失代偿期肝硬化患者50例疗效观察[J].实用肝脏病杂志, 2010, 13 (4) :272-274.[12]CHEN X, SUN GJ, ZHAO WJ, et al.Therapeutic efficacy of autologous bone marrow stem cells transplantation for treatment of terminal liver disease of 24 cases[J].J Clin Hepatol, 2012, 28 (1) :55-57. (in Chinese) 陈曦, 孙国军, 赵文静, 等.自体骨髓干细胞治疗终末期肝病24例临床观察[J].临床肝胆病杂志, 2012, 28 (1) :55-57.[13]Chinese Society of Hepatology and Chinese Society of Infectious Diseases, Chinese Medical Association.The guideline of prevention and treatment for chronic hepatitis B (2010 version) [J].J Clin Hepatol, 2011, 27 (1) :IXVI. (in Chinese) 中华医学会肝病学分会, 感染病学分会.慢性乙型肝炎防治指南 (2010年版) [J].临床肝胆病杂志, 2011, 27 (1) :I-XVI.
  • 加载中
计量
  • 文章访问数:  3029
  • HTML全文浏览量:  10
  • PDF下载量:  599
  • 被引次数: 0
出版历程
  • 收稿日期:  2013-02-08
  • 出版日期:  2013-11-20
  • 分享
  • 用微信扫码二维码

    分享至好友和朋友圈

目录

    /

    返回文章
    返回