Abstract: Objective To identify the species of pathogens in liver cirrhosis patients with sepsis and screen out the effective antibiotics, and to provide a basis for effective clinical antimicrobial therapy. Methods Blood samples were collected from liver cirrhosis patients with suspected bloodstream infections and were then injected into the blood culture bottles at the bedside. Blood was cultured using the BacT / Alert3D system. The isolated strains were identified by the Vitec II or API system ( BioMerieux, France) . Drug susceptibility tests were performed by Kirby- Bauer method. The pathogens and effective drugs in recent 10 years were analyzed. Results A total of 8543 strains of pathogens were isolated from various samples in recent 10 years, and 2065 ( 24. 2%) of them were detected from cultured blood, including1233 ( 59. 7%) Gram- negative bacillus strains, 787 ( 38. 1%) Gram- positive coccus strains, 28 ( 1. 4%) fungal strains, and 17 ( 0. 8%) other pathogenic strains. The drug sensitivity tests showed that Gram- negative bacteria had relatively low resistance to meropenem ( 7. 46%) , imipenem ( 6. 49%) , and amikacin ( 5. 27%) , extended spectrum beta- lactamase ( ESBL) - producing strains were more resistant to beta- lactam antibiotics except carbapenems and cefmetazole than ESBL- negative strains, and Gram- positive bacteria were100% sensitive to vancomycin and teicoplanin. Conclusion Gram- negative bacteria are the main pathogens of bloodstream infections in liver cirrhosis patients in our hospital. The pathogens are characterized by diversity and high resistance to many antibiotics. In clinical practice, antimicrobial drugs should be properly used according to the species and drug sensitivity of pathogens, so as to improve the cure rate, and the changing trends in the species and drug sensitivity of pathogens need to be continuously monitored.