铁超载在非酒精性脂肪性肝病中的作用

李光明; 范建高

doi:10.3969/j.issn.1001-5256.2013.12.006

铁超载在非酒精性脂肪性肝病中的作用

DOI: 10.3969/j.issn.1001-5256.2013.12.006

上海交通大学医学院附属新华医院消化内科

基金项目:

国家自然科学基金(81070344&8107322)；中国肝炎基金会王宝恩肝纤维化研究基金(20090007)；上海市科委“创新行动计划”(09140903500)；国家科技部973课题(2012CB517501)；

详细信息

中图分类号: R575.1
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出版历程
- 收稿日期: 2013-08-19
- 出版日期: 2013-12-20

Research progress in role of iron overload in non- alcoholic fatty liver disease

Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine

Research funding:

摘要

摘要: 铁超载是非酒精性脂肪性肝病(NAFLD)的一个研究热点。从铁超载的评估方法、铁超载与血色病基因突变的关系、铁超载在NAFLD中的发生率及铁超载与NAFLD病情进展的关系等方面归纳了铁超载与NAFLD的相关性;从铁超载的原因、铁超载与脂质代谢的关系及铁沉积类型与肝损伤的关系评述了铁超载参与NAFLD进展的机制;从铁超载作为NAFLD危险分层的新标志物及可能的治疗靶点阐述了铁超载在NAFLD诊疗中的意义。目前认为不论铁超载是NAFLD进展的原因还是结果,一旦出现都将促进NAFLD进展;铁超载作为NAFLD危险分层的新标志物及治疗靶位值得进一步研究。
- 铁超负荷 /
- 脂肪肝
Abstract: Iron overload is an important research focus in non-alcoholic fatty liver disease ( NAFLD) . The relationship between iron overload and NAFLD is summarized from the assessment method for iron overload, relationship between iron load and hemochromatosis gene mutations, incidence of iron load in NAFLD, and relationship between iron load and progression of NAFLD; the action mechanism of iron overload in the progression of NAFLD is reviewed from the causes of iron overload, relationship between iron overload and lipid metabolism, and relationship between type of iron deposition and liver damage; the significance of iron overload in the diagnosis and treatment of NAFLD is discussed from iron overload as a new marker of risk stratification and potential therapeutic target in NAFLD. It is currently considered that iron overload, whether the cause or result of NAFLD progression, will promote the progression of NAFLD once it occurs; as a new marker of risk stratification and potential therapeutic target in NAFLD, iron load is worthy of further study.
- iron overload /
- fatty liver

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参考文献(31)

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