非酒精性脂肪性肝炎无创诊断的研究进展

杨硕; 吕栋; 徐有青

doi:10.3969/j.issn.1001-5256.2013.12.007

非酒精性脂肪性肝炎无创诊断的研究进展

DOI: 10.3969/j.issn.1001-5256.2013.12.007

首都医科大学附属北京天坛医院消化内科

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中图分类号: R575.1
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出版历程
- 收稿日期: 2013-07-31
- 出版日期: 2013-12-20

Research advances in noninvasive diagnosis of nonalcoholic steatohepatitis

Department of Gastroenterology, Beijing Tiantan Hospital, Capital Medical University

摘要

摘要: 非酒精性脂肪性肝炎（NASH）是非酒精性脂肪性肝病进展过程中的关键阶段。目前肝组织活检是诊断NASH的金标准,但此项检查因为有创伤、有风险等缺点而不能被广泛接受,故寻找特异性和敏感性均相对较高的NASH无创诊断方法是当前研究的热点之一。总结与NASH无创诊断密切相关的CK-18、转化生长因子β1、AST/血小板比值等血清学检查及超声、瞬时弹性成像、磁共振弹性成像等影像学检查,发现每种检查方法各有利弊,但也提示联合应用2种或2种以上的检查方法可能成为日后NASH无创诊断的研究方向。
- 脂肪肝 /
- 血清学试验 /
- 诊断显像
Abstract: Nonalcoholic steatohepatitis ( NASH) is a key stage in the progression of nonalcoholic fatty liver disease. Now liver biopsy is the gold standard for diagnosing NASH, but it cannot be widely used due to its invasiveness and potential hazards. Therefore, searching for noninvasive diagnostic methods for NASH with relatively high sensitivity and specificity is a hotspot of current research. The examination methods closely related to noninvasive diagnosis of NASH, such as serological tests for CK-18, TGF-β1, APRI, etc. and imaging examinations including ultrasound, TE, and MRE, are summarized. It is found that each method has advantages and disadvantages, suggesting that joint use of two or more examination methods may be the research direction for noninvasive diagnosis of NASH.
- fatty liver /
- serology tests /
- diagnostic imaging

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参考文献(31)

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