酒精性肝病面临的挑战和今后研究方向

高斌; 王艳

doi:10.3969/j.issn.1001-5256.2014.02.001

酒精性肝病面临的挑战和今后研究方向

DOI: 10.3969/j.issn.1001-5256.2014.02.001

高斌,
王艳

1. 美国国立卫生研究院酒精依赖和酒精滥用研究所,肝病研究室
2. 北京大学第一医院肝病中心暨感染疾病科

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中图分类号: R575
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出版历程
- 出版日期: 2014-02-20

Challenge and direction of research on alcoholic liver disease

Gao Bin,
Wang Yan

摘要

摘要:
酒精性肝病(ALD)作为非感染性肝病的代表将取代病毒性肝炎成为未来肝脏疾病的主要病因之一。中国、亚太、欧洲以及美国肝病年会分别在2010年、2012年、2012年以及2010年更新的ALD诊疗指南中就ALD的诊断标准、临床分型以及治疗做了全面的阐述,但并未涉及具体的发病机制和治疗新靶点的探索。总结述评了ALD的发病机制、治疗新靶点以及近期的研究热点。白细胞介素22、CXC趋化因子拮抗剂以及益生菌等都有可能成为新的有效治疗靶点。而中西方人种酒精代谢特点和ALD疾病谱的差异、ALD的风险因素以及研究ALD适宜的动物模型的探索将可能成为本领域未来研究的热点和方向。
- 肝脏疾病,酒精性 /
- 述评
Abstract:
Alcoholic liver disease ( ALD) will likely become one of major etiologies of chronic liver diseases in the future. The diagnosis and management of ALD were recently updated bythe EASL, AASLD, APASL, and Chinese clinical practical guidelines in 2010- 2012. However, the pathogenesis of ALD still remains obscure. In this editorial, we briefly summarize the recently discovered molecular mechanisms, chronic- binge ethanol feeding model ( Gao- binge model) , and therapeutic targets for ALD. We also discuss the different characteristics of ALD between China and Western countries due to differences in ALDH2 genotypes and other genetic factors, drinking patterns, and co- factors. The number of ALD patients is alarmingly rising in China, so it is critical to conduct nationwide large- scale epidemiological ALD surveys, to promote basic and clinical ALD research, and explore novel therapies for ALD in China.
- liver disease, alcoholic /
- editorial

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参考文献(17)

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