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三维适形放疗与调强放疗治疗原发性肝癌伴门静脉癌栓的剂量学比较

周媛媛 张思杏 郑青平 石成良 罗展雄 李旌 于斌 李中华

周媛媛, 张思杏, 郑青平, 石成良, 罗展雄, 李旌, 于斌, 李中华. 三维适形放疗与调强放疗治疗原发性肝癌伴门静脉癌栓的剂量学比较[J]. 临床肝胆病杂志, 2014, 30(3): 245-248. DOI: 10.3969/j.issn.1001-5256.2014.03.012.
引用本文: 周媛媛, 张思杏, 郑青平, 石成良, 罗展雄, 李旌, 于斌, 李中华. 三维适形放疗与调强放疗治疗原发性肝癌伴门静脉癌栓的剂量学比较[J]. 临床肝胆病杂志, 2014, 30(3): 245-248. DOI: 10.3969/j.issn.1001-5256.2014.03.012.
Zhou YuanYuan, Zhang SiXing, Zheng QingPing, Shi ChengLiang, Luo ZhanXiong, Li Jing, Yu Bin, Li ZhongHua. Dosimetric comparison of 3DCRT and IMRT in treatment of primary hepatocellular carcinoma with portal vein tumor thrombus[J]. J Clin Hepatol, 2014, 30(3): 245-248. DOI: 10.3969/j.issn.1001-5256.2014.03.012.
Citation: Zhou YuanYuan, Zhang SiXing, Zheng QingPing, Shi ChengLiang, Luo ZhanXiong, Li Jing, Yu Bin, Li ZhongHua. Dosimetric comparison of 3DCRT and IMRT in treatment of primary hepatocellular carcinoma with portal vein tumor thrombus[J]. J Clin Hepatol, 2014, 30(3): 245-248. DOI: 10.3969/j.issn.1001-5256.2014.03.012.

三维适形放疗与调强放疗治疗原发性肝癌伴门静脉癌栓的剂量学比较

DOI: 10.3969/j.issn.1001-5256.2014.03.012
基金项目: 

广西壮族自治区卫生厅自筹经费课题(Z2011294); 

详细信息
  • 中图分类号: R735.7

Dosimetric comparison of 3DCRT and IMRT in treatment of primary hepatocellular carcinoma with portal vein tumor thrombus

Research funding: 

 

  • 摘要:

    目的评估三维适形放疗(3DCRT)与调强放疗(IMRT)2种不同放疗技术在原发性肝癌伴门静脉癌栓放射治疗中的优缺点。方法 20例不能手术的原发性肝癌并门静脉癌栓的患者分别进行3DCRT和IMRT 2种放疗计划设计,处方剂量均为40 Gy/20 f。比较2组计划的靶区与危及器官剂量学参数及加速器跳数(MU)。2组间比较采用t检验。结果 IMRT在计划靶体积(PTV)的剂量覆盖、均一性及适形度均优于3DCRT(P<0.05);3DCRT与IMRT的肝V30 Gy及肝V20 Gy分别为33.55±5.67vs 29.41±2.67(P=0.001)和44.24±6.17 vs 41.28±4.59(P=0.021)。2组的正常肝组织低剂量区范围与胃、小肠、脊髓、双肾的受照射剂量并无显著性差异。3DCRT与IMRT的MU分别为303.7±35.8和377.4±33.2(P=0.000)。结论与3DCRT相比,IMRT有较满意的PTV高剂量覆盖及均匀的剂量分布。在危及器官保护方面,IMRT的肝脏高剂量区范围明显低于3DCRT,而不足的是,IMRT的治疗时间显著长于3DCRT。

     

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