高尔基体分泌型聚集素的表达在肝细胞癌进展中的作用

郑文杰; 姚登福

doi:10.3969/j.issn.1001-5256.2014.03.022

高尔基体分泌型聚集素的表达在肝细胞癌进展中的作用

DOI: 10.3969/j.issn.1001-5256.2014.03.022

南通大学附属医院临床医学研究中心

基金项目:

国家国际科技合作项目(2013DFA32150)；江苏省临床医学专项(BL2012053)；

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2014-03-20

Role of Golgi secretory clusterin expression in progression of hepatocellular carcinoma

Research funding:

摘要

摘要:
肝细胞癌(HCC)是连续、多中心、多病因的发展过程。现今已有多种药物投入HCC临床试验,但因其具有高侵袭和高转移能力,预后并不理想。阐述了聚集素(CLU)的结构特点及生物学特性;介绍了分泌型聚集素(sCLU)与HCC发生发展关系的研究进展,指出聚集素过表达可促进肝癌转移,诱导上皮间质转换,抑制肝癌细胞凋亡并可导致耐药。此外简介了第二代反义核酸药物Custirsen的分子结构,在体外可下调HCC侵袭能力。提出sCLU可从多方面促进HCC的发生发展,其分子机制值得进一步探究。
- 癌,肝细胞 /
- 高尔基体 /
- 聚集素 /
- 综述
Abstract:
Hepatocellular carcinoma ( HCC) is a progressive, multi- center, and multi- cause disease. Nowadays, numerous drugs have been investigated in clinical trials for treatment of HCC, but the prognosis was usually poor because HCC is highly invasive and metastatic. The structural characteristics and biological properties of clusterin ( CLU) are described; the research progress in relationship of secretory CLU ( sCLU) with the development and progression of HCC is summarized, and it is pointed out that the overexpression of CLU may promote cancer metastasis, induce epithelial- mesenchymal transition, inhibit apoptosis of HCC cells, and lead to resistance to chemotherapy drugs. In addition, the molecular structure of second- generation antisense nucleic acid drug Custirsen, which may downregulate the metastasis of HCC in vitro, is briefly presented. It is suggested that sCLU promotes the development and progression of HCC in many ways and deserves further research for its molecular mechanism of action.
- carcinoma, hepatocellular /
- golgi apparatus /
- clusterin /
- review

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参考文献(21)

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