中药有效组分配伍防治肝病的研究现状与前景

孟胜喜; 胡义扬

doi:10.3969/j.issn.1001-5256.2014.04.002

中药有效组分配伍防治肝病的研究现状与前景

DOI: 10.3969/j.issn.1001-5256.2014.04.002

1. 上海中医药大学附属曙光医院肝病研究所
3. 上海市中医临床重点实验室

基金项目:

国家科技重大专项(2012ZX09103-201-048)；国家自然科学基金(81173404)；国家中医药管理局中医肝胆病重点学科；

详细信息

中图分类号: R259
计量
- 文章访问数: 208
- HTML全文浏览量: 10
- PDF下载量: 336
- 被引次数: 0
出版历程
- 收稿日期: 2013-12-27
- 出版日期: 2014-04-20

Prevention and treatment of liver diseases by compatibility of effective traditional Chinese medicine components:review of research and prospect

Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Research funding:

摘要

摘要:
中药有效成分复方秉承中药复方配伍理念和优势,其物质基础相对明确,是中医药现代化研究的重要途径和方法。简述了中药组分/成分复方的研究意义、研究思路,回顾了中药组分复方防治肝病研究现状,并从基于临床中药复方的组分复方探索和针对已知的中药有效组分或成分进行组合研究等两方面详细阐释了中药组分/复方防治肝病的研究策略,指出中药有效组分配伍为创新药物的研究提供了方法和技术体系,是一种继承并发扬中医药理论的创新研究模式,是中医药现代研究的重要途径之一。
- 肝疾病 /
- 中草药 /
- 复方合剂 /
- 综述
Abstract:
The compound of active ingredients of traditional Chinese medicine (TCM) , whose material base is relatively clear, adheres to the concept and advantages of formula compatibility of TCM.Thus, it is an important approach to modern TCM research.The significance of research on compound of TCM components / ingredients, as well as the research ideas, is sketched out, and the current research on compound of TCM components for the prevention and treatment of liver diseases is reviewed.The research strategies for TCM composition / compound for the prevention and treatment of liver diseases are elucidated from the following two aspects:exploring the compound of TCM components based on clinical TCM compound and studying the composition aiming at the effective components or ingredients of TCM that have been known;it is pointed out that the compatibility of effective TCM components, which provides the method and technology system for innovative drug research, is an innovative research model for inheriting and developing the TCM theory and is one of the important approaches to modern TCM research.
- liver diseases /
- drugs, Chinese herhal /
- drug combinations /
- review

HTML全文

参考文献(25)

[1]YAN SR, WANG Y, QIAO YJ.Realization of TCM complex adaptive system based on multi-agent modeling[J].J Beijing Univ Tradit Chin Med, 2007, 30 (10) :653-655. (in Chinese) 颜素容, 王耘, 乔延江.基于多主体的中医药复杂适应系统实现途径[J].北京中医药大学学报, 2007, 30 (10) :653-655.

[2]MIAO MS, MA X, WANG C.Study of compatibility of traditional Chinese medicine effective component[J].Tradit Chin Drug Res Clin Pharmacol, 2009, 20 (5) :487-490. (in Chinese) 苗明三, 马霄, 王灿.中药有效组分配伍的探讨[J].中药新药与临床药理, 2009, 20 (5) :487-490.

[3]ZHANG BL, GAO XM, SHANG HC, et al.Research of the efficacy material and mechanism of compound salvia miltiorrhiza formula[J].Modern Tradit Chin Med Mater Med-World Sci Technol, 2003, 5 (5) :14-17. (in Chinese) 张伯礼, 高秀梅, 商洪才, 等.复方丹参方的药效物质及作用机理研究[J].世界科学技术-中医药现代化, 2003, 5 (5) :14-17.

[4]JIANG TL.Explore significance of research about the theory of efficacy material base of traditional Chinese medicine compound and mechanism[J].Chin J Integr Tradit West Med, 1999, 19 (4) :195-196. (in Chinese) 姜廷良.论中药复方药效物质基础和作用机理研究的意义[J].中国中西医结合杂志, 1999, 19 (4) :195-196.

[5]WANG L, ZHOU GB, LIU P, et al.Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia[J].Pro Natl Acad Sci U S A, 2008, 105 (12) :4826-4831.

[6]SHANG H, ZHANG BL, GAO XM.Research of compatibility of formula[J].Chin J Info Tradit Chin Med, 2002, 9 (7) :6-9. (in Chinese) 商洪才, 张伯礼, 高秀梅.方剂配伍研究探讨[J].中国中医药信息杂志, 2002, 9 (7) :6-9.

[7]LI RM.Simple analysis perplexity of modern research of Chinese medcine, inquiry of foothold、starting point、the key point and brealcthrough of modern research of Chinese medicine[J].Med Philosophy, 2008, 29 (12) :65-66. (in Chinese) 李睿明.浅析中药现代研究的困惑, 探究研究策略[J].医学与哲学, 2008, 29 (12) :65-66.

[8]SUN JL, XUE JB, HU YL, et al.Adjuvanticity of compound Chinese herbal medicinal ingredients and their efficacy comparison with compound Chinese herbal medicines[J].J Nanjing Agricult Univ, 2005, 28 (4) :109-112. (in Chinese) 孙峻岭, 薛家宾, 胡元亮, 等.中药成分复方的佐剂作用及其与中药复方的功效比较[J].南京农业大学学报, 2005, 28 (4) :109-112.

[9]ZHANG BL WANG YY, SHANG HC.Theories and methods used in the research of modern Chinese medicine by drug combination[J].Continuing Med Educ, 2006, 20 (19) :89-91. (in Chinese) 张伯礼, 王永炎, 商洪才.组分配伍研制现代中药的理论和方法[J].继续医学教育, 2006, 20 (19) :89-91.

[10]DOMINGUEZ M, COLMENERO J, BATALLER R.Treatment of liver fibrosis[J].Gastroenterol Hepatol, 2009, 32 (9) :627-632.

[11]FENG Q, LI XM, PENG JH, et al.Protective effects of“CKJ”in rats with CCl4-or DMN-induced fibrosis[J].J Clin Hepatol, 2012, 15 (6) :527-529. (in Chinese) 冯琴, 李雪梅, 彭景华, 等.“CKJ方”对大鼠肝纤维化的防治作用观察[J].实用肝脏病杂志, 2012, 15 (6) :527-529.

[12]WANG L, LIU P, MU YP, et al.Study on TCM recipe and syndrome of Dimethylnitrosamine-induced hepatic fibrosis in rats[J].J Tradit Chin Med, 2006, 47 (12) :929-932. (in Chinese) 王磊, 刘平, 慕永平, 等.二甲基亚硝胺大鼠肝纤维化中医方证研究[J].中医杂志, 2006, 47 (12) :929-932.

[13]WANG L, LIU P, WANG CS, et al.Effects of 5 classical recipes on anti-oxidative stress in rat liver with cirrhosis[J].Chin J Integr Tradit West Med, 2008, 28 (5) :435-439. (in Chinese) 王磊, 刘平, 王春树, 等.不同功效古典方剂对肝硬化大鼠肝组织氧化应激反应的影响[J].中国中西医结合杂志, 2008, 28 (5) :435-439.

[14]TONG X, WANG GQ, WANG L, et al.Changes of hepatic proteome in dimethylnitrusamine-induced cirrhosis in rats treated with Huangqi Tang[J].Chin J Exp Tradit Med Formul, 2010, 16 (11) :111-116. (in Chinese) 仝欣, 王高强, 王磊, 等.基于肝组织差异蛋白质组解析黄芪汤治疗二甲基亚硝胺大鼠肝纤维化的效应机制[J].中国实验方剂学杂志, 2010, 16 (11) :111-116.

[15]TONG X, CHEN GF, LU Y, et al.Uniform designed research on the active ingredients assembling of Huangqi Decoction for inhibition of DMN-induced liver fibrosis[J].Chin J Integr Tradit West Med, 2011, 31 (10) :1389-1393. (in Chinese) 仝欣, 陈高峰, 陆雁, 等.基于均匀设计分析黄芪汤活性组分抗二甲基亚硝胺大鼠肝纤维化的配伍作用[J].中国中西医结合杂志, 2011, 31 (10) :1389-1393.

[16]ZHANG H, FENG Q, HU YY, et al.Prevention and treatment of“Qushi Huayu Decoction”on fatty liver of rats induced by Carbon Tetrachloride along with high-fat and low-protein diet[J].Shanghai J Tradit Chin Med, 2006, 40 (3) :52-55. (in Chinese) 张慧, 冯琴, 胡义扬, 等.祛湿化瘀方对CCl4复合高脂低蛋白饮食诱导的大鼠脂肪肝的防治作用[J].上海中医药杂志, 2006, 40 (3) :52-55.

[17]FENG Q, ZHANG H, HU YY, et al.Effect of Qushi Huayu decoction on prevention and treatment of fatty liver induced by high-fat diet in rats[J].Chin J Integr Tradit West Med Liver Dis, 2006, 16 (1) :26-29. (in Chinese) 冯琴, 张慧, 胡义扬, 等.祛湿化瘀方对单纯高脂饮食诱导的大鼠脂肪肝的防治作用[J].中西医结合肝病杂志, 2006, 16 (1) :26-29.

[18]FENG Q, GOU XJ, MENG SX, et al.Qushi Huayu Decoction inhibits hepatic lipid accumulation by activating AMP-activated protein K inase in vivo and in vitro[J].Evid-Based Compl Alt, 2013, 2013:Article ID 184358.

[19]MENG SX, PENG JH, FENG Q, et al.The role of genipin and geniposide in liver diseases:a review[J].Alt Integr Med, 2013, 2:117.

[20]MENG SX, CAO JM, FENG Q, et al.Roles of chlorogenic acid on regulating glucose and lipids metabolism:a review[J].EvidBased Compl Alt, 2013, 2013:Article ID 801457.

[21]TANG YJ, MENG SX, FENG Q.Screen and verification of Chinese medicine by uniform design for the prevention and treatment of fatty liver[J].Acta Univ Tradit Med Sin Pharmacol Shanghai, 2013, 27 (4) :53-57. (in Chinese) 唐亚军, 孟胜喜, 冯琴, 等.基于均匀设计的防治脂肪肝中药有效组分复方筛选与验证[J].上海中医药大学学报, 2013, 27 (4) :53-57.

[22]CHENG Y, PING J, XU HD, et al.The inhibitory effect of oxymatrine-baicailin compound on hepatitis B viral antigens secretion in HepG2.2.2.15 cells[J].Chin Pharmacol Bull, 2006, 22 (10) :1258-1263. (in Chinese) 成扬, 平键, 许怀栋.氧化苦参碱黄芩苷组合物对HepG 2.2.2.15细胞乙肝病毒抗原表达的抑制作用[J].中国药理学通报, 2006, 22 (10) :1258-1263.

[23]LI JQ, CHEN YX, ZENG MD, et al.The inhibitory effect of oxymatrine on hepatitis B virus[J].Chin J Dig, 2001, 21 (9) :550-552.

[24]ZHAO ZD, HUANG ZS.Experimental study on the anti-liver fibrosis effect of Curcumin and combination of Curcumin and Emodin[J].LISHIZHEN Med Mater Med Res, 2009, 20 (3) :642-644. (in Chinese) 赵珍东, 黄兆胜.姜黄素、姜黄素与大黄素联用抗肝纤维化作用的实验研究[J].时珍国医国药, 2009, 20 (3) :642-644.

[25]KARTHIKESAN K, PARI L, MENON VP.Antihyperlipidemic effect of chlorogenic acid and tetrahydrocurcumin in rats subjected to diabetogenic agents[J].Chem Biol Interact, 2010, 188 (3) :643-650.

施引文献

资源附件(0)

访问统计