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中西医结合治疗190例老年胰腺癌的预后分析

潘岩 刘鲁明 陈震 孟志强 林钧华 陈颢 沈晔华

潘岩, 刘鲁明, 陈震, 孟志强, 林钧华, 陈颢, 沈晔华. 中西医结合治疗190例老年胰腺癌的预后分析[J]. 临床肝胆病杂志, 2014, 30(4): 330-334. DOI: 10.3969/j.issn.1001-5256.2014.04.011.
引用本文: 潘岩, 刘鲁明, 陈震, 孟志强, 林钧华, 陈颢, 沈晔华. 中西医结合治疗190例老年胰腺癌的预后分析[J]. 临床肝胆病杂志, 2014, 30(4): 330-334. DOI: 10.3969/j.issn.1001-5256.2014.04.011.
Pan Yan, Liu LuMing, Chen Zhen, Meng ZhiQiang, Lin JunHua, Chen Hao, Shen YeHua. Prognostic analysis of 190 elderly patients with pancreatic cancer treated by integrated traditional Chinese and Western medicine therapy[J]. J Clin Hepatol, 2014, 30(4): 330-334. DOI: 10.3969/j.issn.1001-5256.2014.04.011.
Citation: Pan Yan, Liu LuMing, Chen Zhen, Meng ZhiQiang, Lin JunHua, Chen Hao, Shen YeHua. Prognostic analysis of 190 elderly patients with pancreatic cancer treated by integrated traditional Chinese and Western medicine therapy[J]. J Clin Hepatol, 2014, 30(4): 330-334. DOI: 10.3969/j.issn.1001-5256.2014.04.011.

中西医结合治疗190例老年胰腺癌的预后分析

DOI: 10.3969/j.issn.1001-5256.2014.04.011
基金项目: 

国家自然科学基金资助项目(81173461,81072942); 

详细信息
  • 中图分类号: R735.9

Prognostic analysis of 190 elderly patients with pancreatic cancer treated by integrated traditional Chinese and Western medicine therapy

Research funding: 

 

  • 摘要:

    目的通过临床回顾性研究对以清胰化积方为主的中西医综合治疗老年胰腺癌进行疗效评估,探讨可行性治疗模式。方法采用Kaplan-Meier方法计算生存期,Log-rank检验进行组间比较,并通过应用Cox比例风险模型对2002年1月至2008年12月期间接受中西医结合治疗的190例老年胰腺癌患者进行多因素分析。结果本组190例老年胰腺癌患者:1年生存率28.42%;3年生存率6.32%;5年生存率2.11%。中位生存期为7.1个月。其中清胰化积组102例,中位生存期8.7个月;非清胰化积方88例,中位生存期4.7个月,差异有统计学意义(P<0.05)。KPS评分<80、CA19-9≥500 U/ml、消瘦(体重在6个月内减轻≥10%)、肝转移、手术方式、全身化疗和清胰化积中药是影响该治疗模式预后的独立影响因子。结论根治手术、全身化疗和清胰化积中药是老年胰腺癌长期生存保护因素。老年胰腺癌Ⅲ期患者可化疗结合清胰化积方中药治疗,Ⅳ期老年胰腺癌患者则应以中药及最佳对症支持治疗为主。

     

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  • 收稿日期:  2013-08-12
  • 出版日期:  2014-04-20
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