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Relationship between serum adiponectin level and metabolic indices in patients with chronic hepatitis B
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摘要:
目的探讨慢性乙型肝炎（CHB）和CHB合并脂肪肝患者血清脂联素（ADP）变化及与体脂、血脂、胰岛素抵抗（IR）的关系。方法选择CHB和CHB合并脂肪肝患者各20例,健康对照组18例,3组年龄、性别比较差异无统计学意义。测量其空腹体质量、腰围（WC）和臀围,检测血清胰岛素（FINS）、糖（FBG）、血脂和ALT、AST等,计算身体质量指数（BMI）、腰臀比（WHR）和胰岛素抵抗指数（HOMA-IR）;采用ELISA法测定血清ADP浓度。计量资料采用均数±标准差（x±s）表示,组间比较采用单因素方差分析,计数资料组间比较采用卡方检验,相关性分析用Pearson相关分析。结果 CHB患者ADP质量浓度为（10.56±2.48）mg/L,CHB合并脂肪肝患者为（4.46±2.16）mg/L,对照组为（6.38±2.91）mg/L,3组差异有统计学意义（F=30.537,P=0.000）。CHB合并脂肪肝患者的BMI、WC、WHR及血清三酰甘油（TG）均明显高于CHB组和对照组（P均<0.01）;3组血清FINS、FBG、胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇...
Abstract:Objective To investigate the relationship of serum adiponectin level with body fat, blood lipids, and insulin resistance (IR) in the patients with chronic hepatitis B (CHB) and patients with CHB and fatty liver.Methods Twenty patients CHB, 20 cases of CHB with fatty liver, and 18 healthy controls were included in the study;there were no significant differences in sex and age between the three groups.Fasting body weight, waist circumference (WC) , hip circumference (HC) , fasting insulin (FINS) , fasting blood glucose (FBG) , total cholesterol (TC) , triglyceride (TG) , high- density lipoprotein cholesterol (HDL- C) , low- density lipoprotein cholesterol (LDL- C) , alanine aminotransferase (ALT) , and aspartate aminotransferase (AST) were measured, and body mass index (BMI) , waist- to- hip ratio (WHR) , and homeostasis model assessment of insulin resistance were calculated.Serum concentrations of adiponectin were determined by enzyme- linked immunosorbent assay.Continuous data was expressed as x ± s, and comparisons between groups were made by one- way analysis of variance;comparisons of categorical data between groups were made by R × C χ2test;correlation analysis was performed by Pearson correlation test.Results The serum adiponectin concentrations of patients with CHB, patients with CHB and fatty liver, and healthy controls were 10.56 ± 2.48, 4.46 ± 2.16, and 6.38 ± 2.91 mg / L, respectively, with significant differences between the three groups (F = 30.537, P = 0.000) .The patients with CHB and fatty liver had significantly higher BMI, WC, WHR, and serum TG level than the CHB patients and healthy controls (P < 0.01) ;there were no significant differences in serum FINS, FBG, TC, HDL- C, LDL- C, and IR values between the three groups.Serum adiponectin level was only negatively correlated with TG in patients with CHB and fatty liver (r =- 0.485, P = 0.015) , but not correlated with BMI, WC, WHR, IR, FINS, FBG, TC, HDL- C, and LDL- C in all patients with CHB.Conclusion Serum adiponectin level significantly increases in the patients with CHB, which may presumably be the result of adiponectin exerting a protective effect on the liver, while it significantly decreases in the patients with CHB and fatty liver, which is closely related to elevated TG.
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Key words:
- hepatitis B, chronic /
- fatty liver /
- adiponectin
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