Correlation between HBV DNA load and ALT level: analysis of 800 patients with chronic hepatitis B
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摘要: 目的分析HBV DNA载量与ALT水平的关系,探讨HBV感染时ALT发生变化的原因。方法以ALT值作为因变量,以HBV DNA作为自变量,应用SPSS 16.0软件对指标进行曲线拟合,建立曲线回归方程后对曲线方程进行分析。结果通过软件分析建立幂模型:R2=0.107,F=85.887,P=0.000,b0=47.785,b1=0.075,b2=0。分析曲线发现随着HBV DNA载量的增加,ALT的值持续升高,但升高幅度越来越小;当HBV DNA载量达到一定范围后,随着HBV DNA载量的增加,ALT的值变化幅度极小,并无限接近某一特定值。结论 ALT的变化与HBV DNA载量有相关性,但HBV DNA可能不是导致ALT值发生变化的最直接的原因。Abstract: Objective To analyze the relationship between hepatitis B virus ( HBV) DNA load and serum alanine aminotransferase ( ALT) level and to investigate the reason that ALT level changes in patients with HBV infection. Methods ALT level ( dependent variable) and HBV DNA load ( independent variable) were subjected to curve fitting using SPSS 16. 0 to establish a curve regression equation and analyze the curve regression equation. Results A power model was established by software analysis, with the following results: R2= 0. 107, F = 85. 887, P = 0. 000, b0= 47. 785, b1= 0. 075, b2= 0. The curve analysis showed that as the HBV DNA load increased, the ALT level kept rising, but at a decreasing rate; within a certain range, the increase in HBV DNA load led to little change in ALT level, which was infinitely close to a certain value. Conclusion ALT level is correlated with HBV DNA load, but HBV DNA may not be the most direct cause of change in ALT level.
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Key words:
- hepcotitis B, chronic /
- hepatitis B virus /
- alanine transaminase /
- linear models
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